Dorzolamide Hydrochloride
- CAS No.
- 130693-82-2
- Chemical Name:
- Dorzolamide Hydrochloride
- Synonyms
- MK 507;mk-0507;Trusopt;Biosopt;CS-1398;L 671152;Dorzalamide;DORZOLAMIDE HCL;Dorzolamide HCI;TRUSOPT; COSOPT
- CBNumber:
- CB7296763
- Molecular Formula:
- C10H17ClN2O4S3
- Molecular Weight:
- 360.9
- MDL Number:
- MFCD00884659
- MOL File:
- 130693-82-2.mol
- MSDS File:
- SDS
| Melting point | 265-2670C |
|---|---|
| alpha | D24 -8.34° (c = 1 in methanol) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol. |
| color | White to Off-White |
| λmax | 254nm(CHCl3:MeOH= aq.)(lit.) |
| Merck | 14,3426 |
| BRN | 5896026 |
| CAS DataBase Reference | 130693-82-2(CAS DataBase Reference) |
| FDA UNII | QZO5366EW7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H373 | |||||||||
| Precautionary statements | P260-P264-P270-P301+P312-P314-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XJ9095163 | |||||||||
| HS Code | 2935904000 | |||||||||
| NFPA 704 |
|
Dorzolamide Hydrochloride price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR1925 | Dorzolamide hydrochloride | 130693-82-2 | 500mg | $302 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1225281 | Dorzolamide hydrochloride United States Pharmacopeia (USP) Reference Standard | 130693-82-2 | 200mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | D4189 | Dorzolamide Hydrochloride >98.0%(HPLC)(T) | 130693-82-2 | 200mg | $177 | 2024-03-01 | Buy |
| Cayman Chemical | 26303 | Dorzolamide (hydrochloride) ≥98% | 130693-82-2 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 14616 | Dorzolamide (hydrochloride) ≥98% | 130693-82-2 | 5mg | $43 | 2023-06-20 | Buy |
Dorzolamide Hydrochloride Chemical Properties,Uses,Production
Description
Dorzolamide hydrochloride was introduced in the U.S.A. as eye drops for the treatment of open-angle glaucoma and ocular hypertension. Dorzolamide is a potent carbonic anhydrase inhibitor that, on topical administration, lowers intraocular pressure (IOP). In a clinical study in patients with bilateral primary open-angle glaucoma or ocular hypertension, dorzolamide (0.7-2%) was found to significantly lower IOP throughout the day. Dorzolamide has been shown to be effective as a single therapy or in combination with β-blockers.
Description
Dorzolamide (hydrochloride) (Item No. 26303) is an analytical reference standard categorized as a carbonic anhydrase inhibitor diuretic. Diuretics have been used in sports doping to reduce weight or anabolic androgenic steroid-induced water retention, or as masking agents. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .
Chemical Properties
White Powder
Originator
Merck (U.S.A.)
Uses
An inhibitor of carbonic anhydrase.
Uses
Dorzolamide HCl Ophthalmic Solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Uses
Antiglaucoma drug;Carbonic anhydrase inhibitor
Uses
analgesic
Uses
Carbonic anhydrase inhibitor. Antiglaucoma agent.
Definition
ChEBI: The hydrochloride salt of dorzolamide. It is used in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.
Manufacturing Process
Manufacturing process for Dorzolamide hydrochloride includes these steps as follows: Step A: Sulfuric Acid Ritter Procedure;Step B: Sulfonylation Procedure Step C: Chlorosulfonylation Procedure;Step D: Amidation Procedure;Step E: Reduction via Borane Generated in situ Procedure;Step F: Maleate Salt Formation Procedure;Step G: Crude Hydrochloride Salt Formation;Step H: Recrystallization Procedure.
brand name
Trusopt (Merck).
Therapeutic Function
Antiglaucoma
Veterinary Drugs and Treatments
Dorzolamide is often used in the contralateral eye of a dog with primary glaucoma to prevent development of bilateral disease. It is also an excellent agent to consider for most secondary glaucomas in dogs and cats because it has no effect on pupil size. Like the related oral carbonic anhydrase inhibitors (dichlorphenamide or Daranide?, methazolamide or Neptazane?), dorzolamide decreases aqueous humor production by the ciliary body epithelium by altering pH and affecting the H+/Na+ active transport exchange mechanism. Oral carbonic anhydrase inhibitors cause numerous systemic side effects such as metabolic acidosis and panting, diarrhea, vomiting, anorexia and others, all of which can be avoided with topical carbonic anhydrase inhibitors.
Dorzolamide Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 | info@pharmachemm.com | China | 241 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
View Lastest Price from Dorzolamide Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-06-20 | Dorzolamide Hydrochloride
130693-82-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2022-12-29 | Dorzolamide Hydrochloride
130693-82-2
|
US $1.99-1.99 / g | 10g | 99.99%HPLC;USP42 | 100kg | Guangzhou Biocar Biotechnology Co.,Ltd. | |
 |
2022-05-14 | Dorzolamide Hydrochloride
130693-82-2
|
US $0.00 / g | 10g | 99.0% | 10tons | Wuhan Godbullraw Chemical Co.,ltd |
-
- Dorzolamide Hydrochloride
130693-82-2
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Dorzolamide Hydrochloride
130693-82-2
- US $1.99-1.99 / g
- 99.99%HPLC;USP42
- Guangzhou Biocar Biotechnology Co.,Ltd.
-
- Dorzolamide Hydrochloride
130693-82-2
- US $0.00 / g
- 99.0%
- Wuhan Godbullraw Chemical Co.,ltd
130693-82-2(Dorzolamide Hydrochloride)Related Search:
6-dihydro-6-methyl-, 7,7-dioxide, monohydrochloride, (4S,6S) DORZOLAMIDEHYDROCHLORIDE(SUBJECTTOPATENTFREE) (S,S)-(-)-5,6-Dihydro-4-ethylamino-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide monohydrochloride 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, monohydrochloride, (4S,6S)- 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, monohydrochloride, (4S-trans)- L 671152 MK 507 Trusopt Biosopt Dorzalamide (4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide Hydrochloride (4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-β]thiopyran-2-sulfonamide 7,7-Dioxide Hydrochloride DorzolaMide Hydrochloride, USP Dorzolamide Hydrochloride (200 mg) Dorzolamide Hydrochloride USP/EP/BP Dorzolamide HydrochlorideQ: What is Dorzolamide Hydrochloride Q: What is the CAS Number of Dorzolamide Hydrochloride Q: What is the storage condition of Dorzolamide Hydrochloride Q: What are the applications of Dorzolamide Hydrochloride Dorzolamide Hydrochloride (1225281) (4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride Dorzolamide For System Suitability EPCR CS-1398 TRUSOPT; COSOPT 4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide hydrochloride Dorzolamide hydrochloride CRS Dorzolamide Hydrochloride RS Dorzolamide for system suitability CRS DorzolamideHydrochloride> Dorzolomide hcl Dorzolamide/L671152/MK507 (4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b] thiopyran-2-sulphonamide 7,7-dioxide hydrochloride. Dorzolamide (4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3- b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride 130693-82-2 30693-82-2 C10H17ClN2O4S3 C10H16N2O4S3ClH C10H16N2O4S3HCl Inhibitors Heterocycles Sulfur & Selenium Compounds Chiral Reagents Intermediates & Fine Chemicals