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AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE structure

CAS No.: 131602-53-4

Chemical Name:: AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE

Synonyms: Aβ25-35;BETA-AMYLOID;GSNKGAIIGLM;-Amyloid(25-35);β-Amyloid (25-35);BETA-AMYLOID (25-35);β-Amyloid (25-35) TFA;25-35) TRIFLUOROACETATE;β-Amyloid peptide(25-35);AMyloid b-Protein (25-35)

CBNumber:: CB7297245

Molecular Formula:: C45H81N13O14S

Molecular Weight:: 1060.27

MDL Number:: MFCD00133076

MOL File:: 131602-53-4.mol

MSDS File:: SDS

Last updated:2024-03-27 11:49:37

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AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE Properties

Boiling point	1517.3±65.0 °C(Predicted)
Density	1.248±0.06 g/cm3(Predicted)
RTECS	BU7435200
storage temp.	-20°C
solubility	insoluble in EtOH; insoluble in H2O; ≥106 mg/mL in DMSO
form	Lyophilized.
pka	3.24±0.10(Predicted)
color	Lyophilized White
Water Solubility	Soluble in water.
Sequence	H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH
InChIKey	WIHBNMPFWRHGDF-SLVFWPMISA-N

SAFETY

Risk and Safety Statements

WGK Germany	3
HS Code	2930909899

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A4559	Amyloid β-Protein Fragment 25-35 ≥97% (HPLC)	131602-53-4	250μg	$53.4	2024-03-01	Buy
Sigma-Aldrich	A4559	Amyloid β-Protein Fragment 25-35 ≥97% (HPLC)	131602-53-4	1mg	$224	2024-03-01	Buy
Alfa Aesar	J66808	Amyloid beta (25-35)	131602-53-4	1mg	$112	2023-06-20	Buy
Tocris	1429	Amyloidbeta-peptide(25-35)(human)	131602-53-4	1	$210	2021-12-16	Buy
Usbiological	214485	β-Amyloid	131602-53-4	1mg	$631	2021-12-16	Buy

Product number	Packaging	Price	Buy
A4559	250μg	$53.4	Buy
A4559	1mg	$224	Buy
J66808	1mg	$112	Buy
1429	1	$210	Buy
214485	1mg	$631	Buy

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE Chemical Properties,Uses,Production

Description

Beta-amyloid protein (Abeta), a major component of senile plaques of Alzheimer's disease (AD) in the brain, causes elevation of the intracellular free Ca2+ level and the production of robust free radicals. Beta-amyloid 25-35 induced apoptosis, characterized by decreased cell viability, neuronal DNA condensation, and fragmentation, is associated with an increase in intracellular free Ca2+ level, the accumulation of reactive oxygen species (ROS), and the activation of caspase-3. All of these effects induced by beta-amyloid 25-35 are reversed by genistein.

Uses

Amyloid β-Protein Fragment 25-35 has been used:

to induce neurotoxicity in cortical cultures
to induce Alzheimer′s disease in rat model
to induce apoptosis in mesenchymal stem cells (MSCs)

General Description

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is derived from the amyloid-β protein.amyloid-β protein, which is mapped to human chromosome 21q21. Aβ25-35 lacks the N-terminal domain and the metal binding site and is majorly generated by proteolytic cleavage of Aβ(1?40) peptides. It has a β-sheet and β-turn structure.

Biological Activity

Amyloid β-peptide (25-35) (human) is a fragment of human amyloid β-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.

Biochem/physiol Actions

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is involved in the pathogenesis of Alzheimer′s disease. Inhibitors of this transition may serve as a potential agent in managing Alzheimer′s disease. It is present in the subiculum and entorhinal cortex neurons of Alzheimer′s brain samples and inclusion-body myositis (IBM) muscle. It binds to receptors present in microglia and is capable of lipid membrane insertion. The functional domain sequence of Aβ comprising of sequence GSNKGAIIGLM elicits neurotrophic and neurotoxic effects. Aβ25-35 exhibits rapid aggregation and displays age dependant neurotoxicity.

Mechanism of action

Amyloid β (Aβ) peptide is a proven major contributing component of neuritic plaques of Alzheimer's disease (AD) . The formation of fibrillar deposits of Aβ peptide in brain is a key step in the pathogenesis of this disease, since the conversion of Aβ from soluble monomer to insoluble fibril is considered to cause the neuronal degeneration and clinical dementia in AD patients. Recent biophysical studies such as electron microscopy, solid-state NMR, Fourier transform infrared (FTIR), and electronic circular dichroism (ECD) spectra indicated that the Aβ fibrils exhibit a high β-sheet content. The conversion of normal Aβ peptides with water-soluble α-helical/random coil structures into the insoluble Aβ aggregates with an extensive β-sheet content is considered to be the predominant event in the onset of AD.

storage

-20°C

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE Suppliers

Global( 173)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12452	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9353	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
GenicBio Limited	+86-21-37621270	service@genicbio.com	CHINA	991	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Shanghai Longyu Biotechnology Co., Ltd.	+8615821988213	info@longyupharma.com	China	2531	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
GenicBio Limited	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
Shanghai Longyu Biotechnology Co., Ltd.	58
career henan chemical co	58
TargetMol Chemicals Inc.	58

View Lastest Price from AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-01-06	β-Amyloid (25-35) 131602-53-4	US $0.10-0.30 / kg	1kg	98%	20 tons	Zibo Hangyu Biotechnology Development Co., Ltd
2023-09-28	AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE 131602-53-4	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2020-02-14	AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE 131602-53-4	US $7.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

β-Amyloid (25-35)
131602-53-4
US $0.10-0.30 / kg
98%
Zibo Hangyu Biotechnology Development Co., Ltd

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE
131602-53-4
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE
131602-53-4
US $7.00 / KG
99%
Career Henan Chemical Co

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE Spectrum

AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE(131602-53-4)MS

131602-53-4(AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE)Related Search:

H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH Amyloid beta-Protein (17-40) ammonium salt AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT) Amyloid β-Protein (3-40) Amyloid Beta-Protein (1-14)

H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH Amyloid β-Protein (4-42) H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-OH H-MET-LEU-GLY-ILE-ILE-ALA-GLY-LYS-ASN-SER-GLY-OH BETA-AMYLOID (1-43)

AMYLOID BETA-PROTEIN (40-1) Amyloid β-Protein (1-6) H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA-THR-VAL-ILE-VAL-OH Amyloid β-Protein (3-42) H-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-OH

AMYLOID BETA-PROTEIN (6-20) H-LYS-LEU-VAL-PHE-PHE-OH H-ILE-ILE-GLY-LEU-MET-OH

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Amyloid beta-peptide(25-35) AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE H-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH AMYLOID BETA-PEPTIDE (25-35) (HUMAN) AMYLOID BETA-PROTEIN FRAGMENT 25-35 AMYLOID BETA-PROTEIN (25-35) AMYLOID-BETA PROTEIN (25-35), HUMAN, MOUSE, RAT GSNKGAIIGLM GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET TRIFLUOROACETATE BETA-AMYLOID (25-35) BETA-AMYLOID PEPTIDE [25-35], HUMAN BETA-AMYLOID, FRAGMENT 25-35 amyloid B-protein fragment 25-35 Amyloidb-Peptide(25-35)(human) -Amyloid(25-35) amyloid β-protein fragment 25-35 Amyloid β-peptide (25-35) (human) AMyloid beta (25-35) huMan AMyloid b-Protein (25-35) M.W. 1060.27 C45H81N13O14S AC-ASN-TRP-CYS-LYS-ARG-GLY-ARG-LYS-GLN-CYS-LYS-THR-HIS-PRO-HIS-NH2: AC-NWCKRGRKQCKTHPH-NH2 1: PN: US20030114510 SEQID Human beta-amyloid peptide(25-35) L-Methionine,glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl- AMyloid β-peptide (25-35) (huMan) Amyloid beta-Protein Fragment 25-35 >=97% (HPLC) β-Amyloid (25-35) TFA AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE USP/EP/BP β-Amyloid (25-35) β-Amyloid peptide(25-35) Glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionine AMYLOID BETA-PROTEIN (HUMAN 25-35) TRIFLUOROACETATE Amyloid beta-Protein (25-35) trifluoroacetate salt BETA-AMYLOID Aβ25-35 Amyloid β-Protein Fragment 25-35 GSNKGAIIGLM(131602 53 4(free base)),GSNKGAIIGLM(131602534(free base)) β-amyloid peptide,Abeta,inhibit,Inhibitor,Amyloid-β,βAmyloid (2535),β Amyloid (25 35) Amyloid β-Protein (25-35) trifluoroacetate salt biotinylated?，Biotin-GSNKGAIIGLM AMyloid β-peptide (25-35) (huMan)TFA β-Amyloid (25-35) (human) 131602-53-4 1932-21-1 C45H81N13O14S1 C45H81N13O14S C48H81N13O14S Neurodegenerative Disease Peptides Peptides BioChemical Amyloid beta Protein Fragments Amino Acids and Peptides Biochemicals and Reagents proteins Alzheimers and Neurodegenerative Disease Research Amyloid beta Protein Fragments