ChemicalBook >> CAS DataBase List >>4-Nitrobenzenesulfonyl chloride
4-Nitrobenzenesulfonyl chloride
- CAS No.
- 98-74-8
- Chemical Name:
- 4-Nitrobenzenesulfonyl chloride
- Synonyms
- NsCl;4-NITROBENZENE-1-SULFONYL CHLORIDE;P-NITROBENZENESULFONYL CHLORIDE;p-Nitrophenylsulfonyl chloride;Nosylchloride;4-NSCl, 99%min;4-NitrobenzenesuL;4-Nitrobenzenesulfon;nosyl ch202-697-9loride;4-Nitrophenylsulfonylchloride
- CBNumber:
- CB7298161
- Molecular Formula:
- C6H4ClNO4S
- Molecular Weight:
- 221.62
- MDL Number:
- MFCD00007445
- MOL File:
- 98-74-8.mol
- MSDS File:
- SDS
Last updated:2025-09-25 17:15:13
| Product description | Number | Pack Size | Price |
| 4-Nitrobenzenesulfonyl chloride 97% | 272248 | 5g | $37.5 |
| 4-Nitrobenzenesulfonyl chloride technical grade, 90% | 170925 | 25g | $58 |
| 4-Nitrobenzenesulfonyl Chloride >98.0%(GC)(T) | N0144 | 5g | $16 |
| 4-Nitrobenzenesulfonyl Chloride >98.0%(GC)(T) | N0144 | 25g | $41 |
| 4-Nitrobenzenesulfonyl chloride 97% | 272248 | 25g | $61.3 |
| More product size | |||
| Melting point | 75 °C |
|---|---|
| Boiling point | 143-144 °C (1.5002 mmHg) |
| Density | 1.602 (estimate) |
| vapor pressure | 0.009Pa at 20℃ |
| refractive index | 1.6000 (estimate) |
| Flash point | 143-144°C/1.5mm |
| storage temp. | Store below +30°C. |
| solubility | soluble in Toluene |
| form | Powder |
| color | yellow |
| PH | 1 (H2O, 20℃) |
| Water Solubility | Insoluble |
| Sensitive | Moisture Sensitive |
| BRN | 746543 |
| Stability | Moisture Sensitive |
| LogP | 2.1 at 20℃ |
| CAS DataBase Reference | 98-74-8(CAS DataBase Reference) |
| FDA UNII | ZU5JD6BHB3 |
| NIST Chemistry Reference | 4-Nitrobenzenesulphonyl chloride(98-74-8) |
| EPA Substance Registry System | Benzenesulfonyl chloride, 4-nitro- (98-74-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H317-H318-H361f | |||||||||
| Precautionary statements | P202-P261-P280-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-52/53 | |||||||||
| Safety Statements | 26-36/37/39-45-61 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 21 | |||||||||
| Hazard Note | Corrosive/Moisture Sensitive | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29049085 | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
4-Nitrobenzenesulfonyl chloride price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 272248 | 4-Nitrobenzenesulfonyl chloride 97% | 98-74-8 | 5g | $37.5 | 2025-07-31 | Buy |
| Sigma-Aldrich | 170925 | 4-Nitrobenzenesulfonyl chloride technical grade, 90% | 98-74-8 | 25g | $58 | 2025-07-31 | Buy |
| TCI Chemical | N0144 | 4-Nitrobenzenesulfonyl Chloride >98.0%(GC)(T) | 98-74-8 | 5g | $16 | 2025-07-31 | Buy |
| TCI Chemical | N0144 | 4-Nitrobenzenesulfonyl Chloride >98.0%(GC)(T) | 98-74-8 | 25g | $41 | 2025-07-31 | Buy |
| Sigma-Aldrich | 272248 | 4-Nitrobenzenesulfonyl chloride 97% | 98-74-8 | 25g | $61.3 | 2025-07-31 | Buy |
4-Nitrobenzenesulfonyl chloride Chemical Properties,Uses,Production
Chemical Properties
yellow to brown powder
Uses
4-Nitrobenzenesulfonyl chloride was used in the synthesis of
- [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate)
- hydroxylamines of sulfadiazine and sulfamethoxazole
- solution phase peptide using N-nosyl-α-amino acids.
Uses
4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate).
Uses
4-Nitrobenzenesulfonyl Chloride is used in the preparation of N-Nosyl-α-amino acid for peptide synthesis.
Production Methods
4,4'-Dinitrodiphenyldisulfide [100-32-3], produced by reaction of 4-chloronitrobenzene with sodium disulfide, is treated with chlorine in HCl – HNO3 by a process similar to that used for 2-nitrobenzenesulfonyl chloride.
Flammability and Explosibility
Not classified
4-Nitrobenzenesulfonyl chloride Preparation Products And Raw materials
Global( 171)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20134 | 58 |
| Chongqing Soarwin Technology Co., Ltd | +86-15790943001 | crystal@sorawin.cn | China | 421 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21610 | 55 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29798 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
View Lastest Price from 4-Nitrobenzenesulfonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | 4-Nitrobenzenesulfonyl chloride
98-74-8
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-08-20 | 4-Nitrobenzenesulfonyl chloride
98-74-8
|
US $0.00-0.00 / kg | 1kg | 99.99% | 20 tons | Chongqing Soarwin Technology Co., Ltd | |
 |
2023-10-09 | 4-Nitrobenzenesulfonyl chloride
98-74-8
|
US $30.00 / KG | 1KG | 99% | 20T | Firsky International Trade (Wuhan) Co., Ltd |
-
- 4-Nitrobenzenesulfonyl chloride
98-74-8
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Nitrobenzenesulfonyl chloride
98-74-8
- US $0.00-0.00 / kg
- 99.99%
- Chongqing Soarwin Technology Co., Ltd
-
- 4-Nitrobenzenesulfonyl chloride
98-74-8
- US $30.00 / KG
- 99%
- Firsky International Trade (Wuhan) Co., Ltd
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4-NITROBENZENESULFONYL CHLORIDE, TECH., 90%
4-Nitrobenzenesulfonylchloride,98%
1-(Chlorosulfonyl)-4-nitrobenzene
Nosylchloride
nosyl ch202-697-9loride
4-NitrobenzenesuL
4-NitrobenzenesulfonylChloride>
4-Nitrobenzenesulfonyl chloride ISO 9001：2015 REACH
TIANFUCHEM--98-74-8--S-Boc-2-mercapto-4,6-dimethylpyrimidine factory price
p-Nitrophenylsulfonyl chloride
4-NITROBENZENE-1-SULFONYL CHLORIDE
P-NITROBENZENESULFONYL CHLORIDE
NsCl
PARA NITRO BENZENE SULFONYL CHLORIDE
4-NSCl, 99%min
Benzenesulfonic Acid Impurity 123
98-74-8
C6H4SClNO4
Organic Building Blocks
Sulfonyl Halides
Sulfur Compounds
SULFONYL CHLORIDE
Building Blocks
Dyestuff Intermediates
Phenyls & Phenyl-Het
Sulphonyl Chlorides
Organic Building Blocks
Sulfonyl Halides
Sulfur Compounds
Phenyls & Phenyl-Het
Sulphonyl Chlorides
Benzene derivatives
Benzene series
98-74-8
