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Clioquinol

Clioquinol
Clioquinol structure
CAS No.
130-26-7
Chemical Name:
Clioquinol
Synonyms
Amebil;Bactol;corque;cortin;hysone;Amoenol;VIOFORM;Emaform;Nioform;oralcer
CBNumber:
CB7298550
Molecular Formula:
C9H5ClINO
Formula Weight:
305.5
MOL File:
130-26-7.mol

Clioquinol Properties

Melting point:
175-183 °C
Boiling point:
350.4±37.0 °C(Predicted)
Density 
1.8959 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).
pka
pKa 8.12(50%aqEtOH t=35.0±0.1 I=0.00 N2atmosphere)(Approximate)
form 
Solid
Water Solubility 
<0.1 g/100 mL at 20 ºC
Merck 
14,5031
BRN 
153637
CAS DataBase Reference
130-26-7(CAS DataBase Reference)
NIST Chemistry Reference
5-Chloro-7-iodo-8-quinolinol(130-26-7)
EPA Substance Registry System
8-Quinolinol, 5-chloro-7-iodo-(130-26-7)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08,GHS06
Signal word  Danger
Hazard statements  H302-H315-H317-H319-H361-H301-H334
Precautionary statements  P301+P310-P284-P501a-P201-P202-P261-P264-P270-P272-P280-P301+P312+P330-P302+P352+P333+P313+P363-P305+P351+P338+P337+P313-P308+P313-P405-P501
Hazard Codes  T
Risk Statements  25
Safety Statements  36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  VC5075000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933492250
Toxicity LD50 orally in cats: 400 mg/kg (Davis)

Clioquinol price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 233165 Clioquinol 130-26-7 1gm $75.2 2018-11-20 Buy
Sigma-Aldrich 1138201 Clioquinol United States Pharmacopeia (USP) Reference Standard 130-26-7 500mg $348 2018-11-13 Buy
TCI Chemical C0187 5-Chloro-8-hydroxy-7-iodoquinoline >97.0%(T) 130-26-7 25g $38 2018-11-22 Buy
TCI Chemical C0187 5-Chloro-8-hydroxy-7-iodoquinoline >97.0%(T) 130-26-7 250g $160 2018-11-22 Buy
Alfa Aesar A11137 5-Chloro-8-hydroxy-7-iodoquinoline, 98% 130-26-7 10g $34.9 2018-11-13 Buy

Clioquinol Chemical Properties,Uses,Production

Chemical Properties

Almost white, light yellow, brownish-yellow or yellowish-grey powder.

Uses

alpha adrenergic blocker, mydriatic, antidepressant

Uses

Used as a topical antifungal treatment

Definition

ChEBI: A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has al o been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.

brand name

Domeform-HC (Bayer); Quin-O-Creme (Marion Merrell Dow); Rheaform Boluses [Veterinary] (Fort Dodge Animal Health); Vioform (Ciba-Geigy);Amebio-formo;Anterobe;Aristoform "d";Aristoform "r";Barquinol hc;Betnorate-c;Britaderm;Britadex-vioform;Carboform;Cloro-yodo-hidroxi;Clorpine;Combias;Copover;Cortex;Corti-glottyl;Dependal;Dermo-quinol;Dermozolan;Dexalocal;Diaban;Dioderm c-c;Diodotracin;Dizenterol;Enteral;Ente-rivo;Enterokin;Enterosan;Entero-valodon;Entero-vioformo;Enterquinol;Entox;Entrasorb;Entrokinol;Fusalor-yodocloro;Fyloxxal;Gmd;Guanosept;Haelan-c;Hocacorten-vioform;Hydroform;Iodo-cortifair;Iodocortindon;Iodo-max;Isoderm;Khlorlinkotsin;Klinicin;Lecortin;Lederform-d;Lemoderm;Linola;Locorten-vioform;Metrijet;Metrityl;Mexafermento;Mexafom;Nasello;Nefurox;Obstecrim;Pedi-cort;Percural;Phen-ortis;Pricort cream;Propaderm-c;Quadriderm;Quin iii;Quina band;Quiniodochlor;Reticus;Sebryl;Sedacol;Septo-canulase;Silic c;Tequinophil;Toptic;Torofor;Unidiarea;Uteroject;Ventribex;Viform;Vioform bolus;Vioform hydrocortisan;Vioform hydrocortisone;Vioforme.

World Health Organization (WHO)

Clioquinol, a halogenated hydroxyquinoline derivative, was introduced into medicine around 1900 as a topical antiseptic and in 1934 oral preparations for the treatment of amoebic dysentery and simple diarrhoea became available. By 1964 its use in Japan had been associated with cases of sub-acute myelo-optic neuropathy (SMON) which reached epidemic proportions resulting in its withdrawal there in 1970. Although relatively few cases of SMON were documented elsewhere, clioquinol was subsequently withdrawn from use in many countries and placed under prescription control in others. It was phased out worldwide by the major manufacturer between 1983 and 1985 on grounds of obsolescence. No adequately controlled evidence was ever generated to demonstrate that clioquinol is effective in bacterial or viral diarrhoea. However, products containing clioquinol and related halogenated hydroxyquinolines continue to be used in some tropical and subtropical countries where amoebiasis remains endemic. Other amoebocides are preferred in the WHO Model List of Essential Drugs. (Reference: (WHODI) WHO Drug Information, 77.1, 9, 1977)

General Description

Cream-colored to brownish-yellow powder. Practically odorless. Decomposes at 178-179°C. Used as a topical anti-infective.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Clioquinol is incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides . Darkens on exposure to light.

Fire Hazard

Flash point data for Clioquinol are not available; however, Clioquinol is probably combustible.

Clinical Use

5-Chloro-7-iodo-8-quinolinol, 5-chloro8-hydroxy-7-iodoquinoline, or iodochlorhydroxyquin (Vioform) occursas a spongy, light-sensitive, yellowish white powder that isinsoluble in water. Vioform was initially used as a substitutefor iodoform in the belief that it released iodine in the tissues.It has been used as a powder for many skin conditions,such as atopic dermatitis, eczema, psoriasis, and impetigo.A 3% ointment or cream has been used vaginally as a treatmentfor Trichomonas vaginalis vaginitis. The best use forVioform is in the topical treatment of fungal infections suchas athlete’s foot and jock itch. A combination with hydrocortisone(Vioform HC) is also available.

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: change in central nervous system electrical function, optic nerve damage, and changes in vision. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, I-, and NOx.

Purification Methods

It crystallises from AcOH or xylene and dry it at 70o in vacuo.[Beilstein 21 III/IV 1190.]

Clioquinol Preparation Products And Raw materials

Raw materials

Preparation Products


Clioquinol Suppliers

Global( 168)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 700 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63729 58

View Lastest Price from Clioquinol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-01 Clioquinol
130-26-7
US $7.00 / KG 1KG 99% 200KG career henan chemical co

Clioquinol Spectrum


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