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Ceftibuten

Ceftibuten
Ceftibuten structure
CAS No.
97519-39-6
Chemical Name:
Ceftibuten
Synonyms
7432S;s7432;cephem;CEFTIBUTEN;Ceftibutene;Cedax:Isocef;cis-ceftibutin;cis-Ceftibuten;antibiotic7432s;cephalosporin7432-s
CBNumber:
CB7299436
Molecular Formula:
C15H14N4O6S2
Formula Weight:
410.42
MOL File:
97519-39-6.mol

Ceftibuten Properties

Boiling point:
966℃
RTECS 
XI0367220
Flash point:
>110°(230°F)
storage temp. 
2-8°C
solubility 
Soluble in aqueous solutions. Also soluble in DMSO
form 
powder
color 
white to beige

SAFETY

WGK Germany  3

Ceftibuten price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0037 Ceftibuten hydrate ≥98% (HPLC) 97519-39-6 10mg $79.3 2018-11-20 Buy
Sigma-Aldrich SML0037 Ceftibuten hydrate ≥98% (HPLC) 97519-39-6 50mg $306 2018-11-20 Buy
Alfa Aesar J66807 Ceftibuten, 95% 97519-39-6 50mg $321 2018-11-13 Buy
Alfa Aesar J66807 Ceftibuten, 95% 97519-39-6 10mg $115 2018-11-13 Buy

Ceftibuten Chemical Properties,Uses,Production

Description

Ceftibuten is a new, once daily, orally active cephalosporin introduced as a treatment of Gram-negative bacteria-related urinarylrespiratory tract and gynecological infections. In vitro studies of 359 strains of Gram-negative bacteria demonstrated that ceftibuten was superior to cefaclor and as active or slightly more active than cefixime and cefteram.

Originator

Shionogi (Japan)

Uses

anorexic, antidepressant, inhibitor of 5HT, norepinephrine & dopamine uptake

Definition

ChEBI: A third-generation cephalosporin antibiotic with a [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino substituent at the 7 position of the cephem skeleton. An orally-administered agent, ceftibuten is used as the dihydrate to tre t urinary-tract and respiratory-tract infections.

brand name

Cedax (Schering);Seftem.

Antimicrobial activity

A semisynthetic cephalosporin formulated as the dihydrate for oral administration.
It exhibits good activity against many Gram-negative bacilli, but its activity against Gram-positive cocci is very poor. It is stable to hydrolysis by the common plasmid-mediated β-lactamases, but not derepressed chromosomal enzymes .
It is rapidly and almost completely absorbed by mouth and is excreted in the urine with a half-life of 1.5–3 h. An oral dose of 400 mg achieves a peak plasma concentration of around 15 mg/L. Binding to plasma proteins is 65–77%.
Side effects mostly consist of mild gastrointestinal symptoms and mild liver function test changes. Clinical trials have mainly been conducted in urinary tract and respiratory tract infections which, despite the poor in-vitro activity against Str. pneumoniae, have shown ceftibuten to be as efficacious as comparator agents.

Clinical Use

Ceftibuten (Cedax) is a recently introduced, chemicallynovel analog of the oximino cephalosporins in which anolefinic methylene group (C=CHCH2-) with Z stereochemistryhas replaced the syn oximino (CBNO-) group.
This isosteric replacement yields a compound that retainsresistance to hydrolysis catalyzed by many β-lactamases,has enhanced chemical stability, and is orally active. Oralabsorption is rapid and nearly complete. It has the highestoral bioavailability of the third-generation cephalosporins.Ceftibuten is excreted largely unchanged in the urine andhas a half-life of about 2.5 hours. Plasma protein binding ofthis cephalosporin is estimated to be 63%.
Ceftibuten possesses excellent potency against mostmembers of the Enterobacteriaceae family, H. influenzae,Neisseria spp., and M. catarrhalis. It is not active against S.aureus or P. aeruginosa and exhibits modest antistreptococcal activity. Ceftibuten is recommended in the managementof community-acquired respiratory tract, urinary tract, andgynecological infections.

Ceftibuten Preparation Products And Raw materials

Raw materials

Preparation Products


Ceftibuten Suppliers

Global( 89)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23982 58
Wellman Pharmaceutical Group Limited 15807197853 027-83778875
027-83991220 15807197853@163.com China 2521 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12343 58
China Kouting Group Limited +86 (21) 5811-6473 5811-6475
+86 (21) 6129-4103 sales@koutingchina.com China 498 60
MedChemexpress LLC 609-228-6898
609-228-5909 sales@medchemexpress.com United States 4612 58
Nanjing Sunlida Biological Technology Co., Ltd. 025-58378339;025-57798810
025-57019371 sales@sunlidabio.com China 3823 55

View Lastest Price from Ceftibuten manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-21 Ceftibuten
97519-39-6
US $7.00 / kg 1kg 99% 100kg career henan chemical co

97519-39-6(Ceftibuten)Related Search:


  • (6R,7R)-7-[[(Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • antibiotic7432s
  • cephalosporin7432-s
  • cephem
  • cis-ceftibutin
  • s7432
  • CEFTIBUTEN
  • 7-[2-(2-amino-1,3-thiazol-4-yl)-4-carboxyisocrotonamide]-3-cephem-4-carboxylic acid
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-4-carboxy-1-oxo-2-butenyl]amino]-8-oxo-, (6R,7R)-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-amino-4-thiazolyl)-4-carboxy-1-oxo-2-butenyl]amino]-8-oxo-, [6R-[6α,7β(Z)]]-
  • 7432S
  • Ceftibuten (SCH 39720)
  • (6r-(6-alpha,7-beta(z)))-yl)-4-carboxy-1-oxo-2-butenyl)amino)-8-oxo
  • [6R-[(6α,7β(Z)]]-7-[[2-(2-Amino-4-thiazolyl)-4-carboxy-1-oxo-2-butenyl]amino]-8-oxo-5-thia-1-azabi-cyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cedax:Isocef
  • (6R,7R)-7-[[(Z)-2-(2-Amino-4-thiazolyl)-4-carboxy-2-butenoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid
  • (6R,7R)-7α-[[(Z)-2-(2-Amino-4-thiazolyl)-4-carboxy-1-oxo-2-butenyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-4-carboxy-1-oxo-2-buten-1-yl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
  • MERIDIA
  • -
  • API
  • Ceftibutene
  • cis-Ceftibuten
  • 97519-39-6
  • C15H14N4O6S2
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