3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZONITRILE
![3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZONITRILE Structure](CAS/GIF/859850-90-1.gif)
- CAS No.
- 859850-90-1
- Chemical Name:
- 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZONITRILE
- Synonyms
- 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZONITRILE;Benzonitrile,3-[(4-methyl-1-piperazinyl)methyl]-
- CBNumber:
- CB7302116
- Molecular Formula:
- C13H17N3
- Molecular Weight:
- 215.29
- MDL Number:
- MFCD07772861
- MOL File:
- 859850-90-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile | M321285 | 50mg | $55 |
| 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile | M321285 | 100mg | $85 |
| 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile | M321285 | 1g | $440 |
| 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile | 7575CQ | 10g | $392 |
| 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile >95% | 126990 | 5g | $1512 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| HS Code | 2933599590 | |||||||||
| NFPA 704 |
|
3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZONITRILE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M321285 | 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile | 859850-90-1 | 50mg | $55 | 2021-12-16 | Buy |
| TRC | M321285 | 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile | 859850-90-1 | 100mg | $85 | 2021-12-16 | Buy |
| TRC | M321285 | 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile | 859850-90-1 | 1g | $440 | 2021-12-16 | Buy |
| AK Scientific | 7575CQ | 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile | 859850-90-1 | 10g | $392 | 2021-12-16 | Buy |
| Matrix Scientific | 126990 | 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile >95% | 859850-90-1 | 5g | $1512 | 2021-12-16 | Buy |
3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZONITRILE Chemical Properties,Uses,Production
Uses
3-((4-Methylpiperazin-1-yl)methyl)benzonitrile is involved in the preparation of N-Hydroxyphenylacrylamides and N-Hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.
Synthesis
109-01-3
24964-64-5
![3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZONITRILE](/CAS/GIF/859850-90-1.gif)
859850-90-1
General procedure for the synthesis of 3-((4-methylpiperazin-1-yl)methyl)benzonitrile from N-methylpiperazine and 3-cyanobenzaldehyde: Step 1: 3-Formylbenzonitrile (1.5 g, 11.45 mmol), N-methylpiperazine (1.49 g, 14.9 mmol) and sodium triacetoxyborohydride (3.63 g, 17.18 mmol) were dissolved in dichloromethane (75 ml), acetic acid (0.851 ml, 14.9 mmol) was added and the reaction was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was diluted with dichloromethane and washed with 1 M sodium carbonate solution. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: dichloromethane/methanol/ammonia = 97:3:0.5) to give 3-(4-methylpiperazin-1-ylmethyl)benzonitrile 1.7 g in 70% yield.
References
[1] Patent: WO2007/113249, 2007, A2. Location in patent: Page/Page column 60-61
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 2, p. 822 - 839
[3] Patent: EP2033956, 2009, A1. Location in patent: Page/Page column 13
[4] Patent: WO2006/130075, 2006, A1. Location in patent: Page/Page column 25-26
3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZONITRILE Preparation Products And Raw materials
Raw materials
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Preparation Products
3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZONITRILE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17770 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22514 | 55 |
| Shanghai XR Chemical Technology Co., Ltd. | 021-31007982 18019432809 | info@xrpharma.com | China | 678 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 12346 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71615 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 0519-85528066 13775048983 | sales@hopschem.com | China | 31553 | 55 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
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