Chinese Japanese Germany Korea

Dilthiazem hydrochloride

Dilthiazem hydrochloride
Dilthiazem hydrochloride structure
Chemical Name:
Dilthiazem hydrochloride
Molecular Formula:
Formula Weight:
MOL File:

Dilthiazem hydrochloride Properties

Melting point:
212-214 °C
D24 +98.3 ± 1.4° (c = 1.002 in methanol)
refractive index 
118 ° (C=1, H2O)
Flash point:
storage temp. 
Freely soluble in water, in methanol and in methylene chloride, slightly soluble in anhydrous ethanol.
White to off-white
pH (10g/l, 25℃) : 4.3~5.3
Water Solubility 
CAS DataBase Reference
33286-22-5(CAS DataBase Reference)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi,F
Risk Statements  22-40-36/37/38-36-20/21/22-11
Safety Statements  36-45-36/37-26-16
RIDADR  3249
WGK Germany  3
RTECS  DL0310000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29349990
Toxicity LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Dilthiazem hydrochloride price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 309866 Diltiazem, Hydrochloride Synthetic benzothiazepine that acts as an L-type Ca 33286-22-5 100mg $75.2 2018-11-20 Buy
Sigma-Aldrich 1205003 Diltiazem hydrochloride United States Pharmacopeia (USP) Reference Standard 33286-22-5 200mg $348 2018-11-13 Buy
TCI Chemical D3662 (+)-cis-Diltiazem Hydrochloride >98.0%(HPLC)(T) 33286-22-5 5g $90 2018-11-22 Buy
TCI Chemical D3662 (+)-cis-Diltiazem Hydrochloride >98.0%(HPLC)(T) 33286-22-5 25g $278 2018-11-22 Buy
Alfa Aesar J63245 (+)-cis-Diltiazem hydrochloride 33286-22-5 5g $97 2018-11-13 Buy

Dilthiazem hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Fine Needles


An antianginal, antihypertensive. Regulates Calcium release from intracellular stores in neutrophils


A calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).


antihypertensive, sedative, antibacterial


Peripheral Vasodilator


ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension.

brand name

Cardizem (Biovail); Cartia (Andrx); Dilacor (Watson); Diltzac (Apotex); Taztia (Andrx); Tiazac (Biovail).

General Description

Diltiazem hydrochloride,(+)-cis-3-(acetoxy)-5-[2(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)1,5-benzothiazepin-4(5H)one hydrochloride(Cardizem), was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.
The drug is absorbed rapidly and almost completely fromthe digestive tract. It reaches peak plasma levels within 1hour after administration in gelatin capsules. Oral formulationson the market are sustained-release preparations providingpeak plasma levels 3 to 4 hours after administration.

Biological Activity

Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca 2+ channels.

Dilthiazem hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Dilthiazem hydrochloride Suppliers

Global( 230)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21990 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 3015 60
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24001 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40277 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 Germany 3580 66
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 China 15884 69

33286-22-5(Dilthiazem hydrochloride)Related Search:

Copyright 2017 © ChemicalBook. All rights reserved