Bempedoic acid
- CAS No.
- 738606-46-7
- Chemical Name:
- Bempedoic acid
- Synonyms
- Bempedoic Acid;Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-;CS-1544;ETC-1002;ESP 55016;Bempedoic;Bempedoate;Bempdic acid;Bempedoic Acid, API;ETC-1002 (ESP 55016)
- CBNumber:
- CB73034632
- Molecular Formula:
- C19H36O5
- Molecular Weight:
- 344.49
- MDL Number:
- MFCD18800820
- MOL File:
- 738606-46-7.mol
- MSDS File:
- SDS
| Melting point | 87 - 92°C |
|---|---|
| Boiling point | 506.5±35.0 °C(Predicted) |
| Density | 1.045±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 4.55±0.45(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24) |
| InChIKey | HYHMLYSLQUKXKP-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O |
| FDA UNII | 1EJ6Z6Q368 |
| ATC code | C10AX15 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Bempedoic acid price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26409 | ETC-1002 | 738606-46-7 | 25mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 26409 | ETC-1002 | 738606-46-7 | 50mg | $122 | 2024-03-01 | Buy |
| Cayman Chemical | 26409 | ETC-1002 | 738606-46-7 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 26409 | ETC-1002 | 738606-46-7 | 10mg | $50 | 2024-03-01 | Buy |
| TRC | B119700 | BempedoicAcid | 738606-46-7 | 250mg | $605 | 2021-12-16 | Buy |
Bempedoic acid Chemical Properties,Uses,Production
Description
ETC-1002 is a prodrug form of ETC-1002-CoA. ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.
Description
Etc-1002 is a small molecule that can be used orally to lower LDL-C and is an activator of LIVER AMPK. ETC-1002 has an effective inhibitory effect on liver ATP-Citrate lyase.
Uses
ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).
Definition
ChEBI: Bempedoic acid is an alpha,omega-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. It is a drug used for the treatment of high LDL cholesterol, which is sometimes referred to as 'bad cholesterol'. It has a role as an antilipemic drug, an EC 2.3.3.8 (ATP citrate synthase) inhibitor and a prodrug.
Indications
Bempedoic acid (ETC-1002) is a lipid-lowering agent approved by the FDA for use as an adjunct to maximally tolerated statin therapy for the reduction of LDL cholesterol, particularly in patients with atherosclerotic cardiovascular disease (ASCVD) and heterozygous familial hypercholesterolaemia (HeFH).
brand name
NEXLETOL, NEXLIZET
Mechanism of action
Bempedoic acid (ETC-1002) inhibits cholesterol biosynthesis by inhibiting adenosine triphosphate-citrate lyase (ACL), which in turn inhibits cholesterol biosynthesis, leading to an increase in the expression of the LDL receptor and an enhancement of the plasma clearance of low-density lipoproteins (LDL-C). ETC-1002 is an orally active prodrug that is intracellularly activated. ETC-1002 activates AMPK, which in turn inhibits the production of pro-inflammatory cytokines and chemokines, and also contributes to the amelioration of diseases such as ASCVD and HeFH.
Bempedoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Bempedoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Anhuida Chemical Co., Ltd | +8615903659408 | admin@ahdchem.com | China | 297 | 58 |
| Beijing Hope Pharmaceutical Co., Ltd. | +86-010-67886402 +8613611125266 | market@hopelife.cn | China | 71 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9357 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 801 | 55 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19536 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Related articles
- How is Bempedoic Acid Synthesised?
- Bempedoic Acid (ETC-1002) is synthesised using ethyl isobutyrate as raw material by chemical reaction.
- Dec 27，2023
View Lastest Price from Bempedoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-09-18 | Bempedoic acid
738606-46-7
|
US $0.00 / G | 1G | 98%min | 30kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-03-28 | Bempedoic Acid
738606-46-7
|
US $0.00 / KG | 25KG | 98% | Inquiry | PNP Biotech Co. Ltd | |
 |
2022-10-11 | Bempedoic acid (ETC-1002)
738606-46-7
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Bempedoic acid
738606-46-7
- US $0.00 / G
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Bempedoic Acid
738606-46-7
- US $0.00 / KG
- 98%
- PNP Biotech Co. Ltd
-
- Bempedoic acid (ETC-1002)
738606-46-7
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.