5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
- CAS No.
- 1225037-39-7
- Chemical Name:
- 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
- Synonyms
- PQR309;CS-2024;PI3K-IN-2;Bimiralisib;PQR-309, >98%;PQR309 Bimiralisib;Bimiralisib (PQR309);PQR309;PQR 309;PQR-309;Bimiralisib (PQR309)(free base);BIMIRALISIB;PQR309;PQR 309;PQR-309
- CBNumber:
- CB73039400
- Molecular Formula:
- C17H20F3N7O2
- Molecular Weight:
- 411.38
- MDL Number:
- MFCD28902193
- MOL File:
- 1225037-39-7.mol
Boiling point | 643.7±65.0 °C(Predicted) |
---|---|
Density | 1.418±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility |
DMSO:22.0(Max Conc. mg/mL);53.48(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);24.31(Max Conc. mM) Ethanol:2.0(Max Conc. mg/mL);4.86(Max Conc. mM) |
form | A crystalline solid |
pka | 4.92±0.10(Predicted) |
color | White to gray |
FDA UNII | 6Z3QHB00LB |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
NFPA 704 |
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5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 23441 | Bimiralisib ≥98% | 1225037-39-7 | 1mg | $36 | 2024-03-01 | Buy |
Cayman Chemical | 23441 | Bimiralisib ≥98% | 1225037-39-7 | 5mg | $155 | 2024-03-01 | Buy |
Cayman Chemical | 23441 | Bimiralisib ≥98% | 1225037-39-7 | 10mg | $290 | 2024-03-01 | Buy |
Cayman Chemical | 23441 | Bimiralisib ≥98% | 1225037-39-7 | 25mg | $638 | 2024-03-01 | Buy |
ChemScene | CS-4672 | Bimiralisib 98.74% | 1225037-39-7 | 100mg | $640 | 2021-12-16 | Buy |
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine Chemical Properties,Uses,Production
Description
Bimiralisib is a potent and orally bioavailable inhibitor of phosphatidylinositol 3-kinases (PI3Ks; IC50s = 33, 661, 708, and 451 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively) and the mammalian target of rapamycin (mTOR; IC50 = 89 nM). It is selective for these kinases over a panel of cell surface and nuclear receptors, membrane channels, transporters, kinases, proteases, and phosphodiesterases at a concentration of 10 μM. Bimiralisib has anticancer activity with an average GI50 value of 0.7 μM across the National Cancer Institute (NCI) 60 human cancer cell line panel. In vivo, bimiralisib (5-15 mg/kg) reduces tumor growth in a dose-dependent manner in a PC3 prostate cancer mouse xenograft model. Formulations containing bimiralisib are under clinical investigation for the treatment of relapsed and refractory lymphoma and advanced solid tumors.
Uses
Bimiralisib is an orally bioavailable PI3K/mTOR inhibitor for cancer
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
View Lastest Price from 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-09-06 | 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
1225037-39-7
|
US $1.00 / KG | 1KG | 95%~99% | per week 100kg | Career Henan Chemical Co |
- 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
1225037-39-7
- US $1.00 / KG
- 95%~99%
- Career Henan Chemical Co