PEG4-tert-butyl acetate
- CAS No.
- 169751-72-8
- Chemical Name:
- PEG4-tert-butyl acetate
- Synonyms
- OH-PEG4-CH2COOH;OH-PEG4-CH2COOtBu;HO-PEG4-CH2COOtBu;HO-PEG4-CH2CO2t-Bu;PEG5-t-butyl acetate;Hydroxy-PEG4-CH2-Boc;Hydroxy-PEG4-CH2COOtBu;Hydroxy-PEG4-CH2CO2tBu;EG4-tert-butyl acetate;PEG5-tert-butyl acetate
- CBNumber:
- CB73049630
- Molecular Formula:
- C14H28O7
- Molecular Weight:
- 308.37
- MDL Number:
- MFCD27635170
- MOL File:
- 169751-72-8.mol
| Product description | Number | Pack Size | Price |
| HO-PEG4-CH2COOtBu 97+% | AS118042 | 1g | $225 |
| Tert-Butyl14-hydroxy-3,6,9,12-tetraoxatetradecan-1-oate | 7226DN | 1g | $424 |
| HO-PEG4-CH2CO2t-Bu | BIPG1425 | 250mg | $662 |
| HO-PEG4-CH2COOtBu 97+% | AS118042 | 5G | $842 |
| Hydroxy-PEG4-CH2CO2tBu 95% | BP-22028 | 5G | $1940 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
PEG4-tert-butyl acetate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS118042 | HO-PEG4-CH2COOtBu 97+% | 169751-72-8 | 1g | $225 | 2021-12-16 | Buy |
| AK Scientific | 7226DN | Tert-Butyl14-hydroxy-3,6,9,12-tetraoxatetradecan-1-oate | 169751-72-8 | 1g | $424 | 2021-12-16 | Buy |
| Apolloscientific | BIPG1425 | HO-PEG4-CH2CO2t-Bu | 169751-72-8 | 250mg | $662 | 2021-12-16 | Buy |
| Activate Scientific | AS118042 | HO-PEG4-CH2COOtBu 97+% | 169751-72-8 | 5G | $842 | 2021-12-16 | Buy |
| BroadPharm | BP-22028 | Hydroxy-PEG4-CH2CO2tBu 95% | 169751-72-8 | 5G | $1940 | 2021-12-16 | Buy |
PEG4-tert-butyl acetate Chemical Properties,Uses,Production
Description
Hydroxy-PEG4-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Hydroxy-PEG4-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Synthesis
![Bis[2-(2-hydroxyethoxy)ethyl] ether](/CAS/GIF/112-60-7.gif)
112-60-7
5292-43-3
169751-72-8
GENERAL STEPS: To a stirred mixture of tert-butyl 2-bromoacetate (5.4 mL, 36.6 mmol) and 2,2'-((oxo-bis(ethane-2,1-diyl))bis(oxy))diethanol (35.0 mL, 203 mmol) in DMSO (50 mL) was added in two additions of NaH (1.6217 g, 40.6 mmol, a 60% oil solution). The reaction mixture was slowly warmed to room temperature with continuous stirring for 23 hours. Subsequently, the reaction solution was diluted with water (50 mL), saturated with NaCl (50 g), stirred for 5 min and extracted with ether (3 x 100 mL). The organic phases were combined and concentrated. The residue was dissolved in dichloromethane (50 mL) and water (25 mL) and stirred for 5 minutes. The organic phases were separated by a phase separator, concentrated, and purified using an 80 g silica gel column with a gradient of ethyl acetate in hexanes as eluent (50-100%) to afford tert-butyl 14-hydroxy-3,6,9,12-tetraoxatetradecane-1-carboxylate (8.2 g, 72.7% yield) as a light yellow oil. rf = 0.08 (ethyl acetate). NMR hydrogen spectrum (400 MHz, CDCl3) δ 4.02 (d, J = 1.0 Hz, 2H), 3.75-3.60 (m, 12H), 1.47 (s, 9H) ppm. low-resolution mass spectrometry (ESI) m/z: C14H28O7 Calculated value: 308.3679; Measured value: 330.95 (M + Na)+; Measured value: 347.01 (M + K)+.
References
[1] Patent: WO2018/200981, 2018, A1. Location in patent: Paragraph 0209; 0294-0295
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 2, p. 583 - 598
[3] Patent: US2018/177750, 2018, A1. Location in patent: Paragraph 1106
PEG4-tert-butyl acetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29798 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5743 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Supplier | Advantage |
|---|---|
| 9i LLC | 58 |
| Accela ChemBio Inc. | 58 |
| career henan chemical co | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Wuhan Borenpharm Co., Ltd | 58 |
| ANHUI WITOP BIOTECH CO., LTD | 58 |
| Nextpeptide Inc | 58 |
| Labnetwork lnc. | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
View Lastest Price from PEG4-tert-butyl acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-21 | Hydroxy-PEG4-CH2-Boc
169751-72-8
|
US $0.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2020-01-10 | PEG4-tert-butyl acetate
169751-72-8
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- Hydroxy-PEG4-CH2-Boc
169751-72-8
- US $0.00 / mg
- TargetMol Chemicals Inc.
-
- PEG4-tert-butyl acetate
169751-72-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
