3BDO
- CAS No.
- 890405-51-3
- Chemical Name:
- 3BDO
- Synonyms
- 3BDO;3BDO >=98% (HPLC);3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one;3BDO, 97%, Activator for mTOR, Autophagy inhibitor;3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one;Pentonic acid, 2,3-dideoxy-5-O-(2-nitrophenyl)-2-(phenylmethyl)-, γ-lactone;Autophagy,3BDO,mTOR,Apoptosis,Mammalian target of Rapamycin,Inhibitor,inhibit
- CBNumber:
- CB73117166
- Molecular Formula:
- C18H17NO5
- Molecular Weight:
- 327.33
- MDL Number:
- MFCD30187363
- MOL File:
- 890405-51-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 29321900 |
3BDO price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1687 | 3BDO ≥98% (HPLC) | 890405-51-3 | 5MG | $110 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1687 | 3BDO ≥98% (HPLC) | 890405-51-3 | 25MG | $440 | 2023-06-20 | Buy |
| ChemScene | CS-0035372 | 3BDO 99.91% | 890405-51-3 | 5mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-0035372 | 3BDO 99.91% | 890405-51-3 | 10mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-0035372 | 3BDO 99.91% | 890405-51-3 | 25mg | $240 | 2021-12-16 | Buy |
3BDO Chemical Properties,Uses,Production
Uses
3BDO has been used to investigate the potential effects of metformin on inflammatory lung injury.
Biochem/physiol Actions
3BDO is a cell-permeable, orally bioavailable, non-toxic butyrolactone derivative that is shown to competitively bind FKBP1A (FK506-binding protein 1A, 12 kDa) in a reversible manner, and suppress autophagy via the mTOR pathway. 3BDO inhibits both LPS- and oxLDL-induced autophagy in HUVECs, increases TIA1 phosphorylation, and reduces autophagosomes number. It is reported to be brain permeant, and significantly decreases atherosclerosis development in apoE-/-?mice (100 mg/kg, q.d., p.o.). 3BDO increases IDE and neprilysin levels, lowers amyloid-β deposition in an AβPP/PS1 transgenic mouse model of Alzheimer′s disease, and alleviates memory deficits.
3BDO Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3419 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| TargetMol Chemicals Inc. | 58 |
| Career Henan Chemica Co | 58 |
| InvivoChem | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | 58 |
| Aladdin Scientific | 58 |
| BOC Sciences | 65 |
| MedChemexpress LLC | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 58 |
| Sigma-Aldrich | 80 |