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Todralazine hydrochloride

Todralazine hydrochloride
Todralazine hydrochloride structure
CAS No.
3778-76-5
Chemical Name:
Todralazine hydrochloride
Synonyms
binazin;binazine;apirachol;ECARAZINE;Apiracohl;Hydrapron;TODRALAZINE HCL;621-bthydrochloride;ECARAZINE HYDROCHLORIDE;TODRALAZINE HYDROCHLORIDE
CBNumber:
CB7312164
Molecular Formula:
C11H13ClN4O2
Formula Weight:
268.7
MOL File:
3778-76-5.mol
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3
RTECS  FE2778600
Toxicity LD50 i.p. in mice: 500 mg/kg (Parravincini)

Todralazine hydrochloride price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20893 Todralazine (hydrochloride) ≥98% 3778-76-5 250mg $68 2021-03-22 Buy
Cayman Chemical 20893 Todralazine (hydrochloride) ≥98% 3778-76-5 500mg $129 2021-03-22 Buy
Cayman Chemical 20893 Todralazine (hydrochloride) ≥98% 3778-76-5 1g $245 2021-03-22 Buy

Todralazine hydrochloride Chemical Properties,Uses,Production

Originator

Prorazin,Teisan

Uses

Antihypertensor

Manufacturing Process

A suspension of 13 g of hydrazinophthalazine in 500 ml of anhydrous ethanol is cooled, under agitation to a temperature of -10°C. To the suspension is added dropwise within 30 min a solution of 4.5 g of ethyl chlorocarbonate in 150 ml of anhydrous ethanol and the reaction mass is agitated for about 2 hours, maintaining a temperature of -10°C. The temperature is then raised to about 20°C and stirring is continued for 2 hours, whereupon heating is applied and boiling is maintained for 15 min. After cooling, the separated 1- hydrazinophthalazine hydrochloride is filtered and washed with anhydrous ethanol.
The filtrate is evaporated to a dry state under decreased pressure at a temperature of below 50°C. The residue in a quantity of 8.5 g is dissolved in a boiling solution of 3 ml of concentrated hydrochloric acid in 15 ml of water, and after adding 5 ml of 90%-ethanol the solution is cooled to a temperature of below 0°C.
The separated 1-carboethoxyhydrazinophthalazine hydrochloride is filtered and washed with anhydrous ethanol. 11.5 g of a raw product are obtained which for the purpose of purification are dissolved in 15 ml of boiling water with an addition of 10 ml of 96%-ethanol and after cooling to below 0°C, the pure 1- carboethoxyhydrazinophthalazine hydrochloride is filtered. 9.8 g of the are obtained.

Therapeutic Function

Antihypertensive

Todralazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Todralazine hydrochloride Suppliers

Global( 33)Suppliers
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BOC Sciences
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Spectrum Chemical Manufacturing Corp. 18616765336
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