Todralazine hydrochloride
- CAS No.
- 3778-76-5
- Chemical Name:
- Todralazine hydrochloride
- Synonyms
- binazin;binazine;apirachol;ECARAZINE;Apiracohl;Hydrapron;TODRALAZINE HCL;621-bthydrochloride;ECARAZINE HYDROCHLORIDE;TODRALAZINE HYDROCHLORIDE
- CBNumber:
- CB7312164
- Molecular Formula:
- C11H13ClN4O2
- Molecular Weight:
- 268.7
- MDL Number:
- MFCD00057321
- MOL File:
- 3778-76-5.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 5 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): slightly |
| form | A crystalline solid |
| FDA UNII | C59540FEXP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H332 | |||||||||
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | FE2778600 | |||||||||
| Toxicity | LD50 i.p. in mice: 500 mg/kg (Parravincini) | |||||||||
| NFPA 704 |
|
Todralazine hydrochloride price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20893 | Todralazine (hydrochloride) ≥98% | 3778-76-5 | 250mg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 20893 | Todralazine (hydrochloride) ≥98% | 3778-76-5 | 500mg | $158 | 2024-03-01 | Buy |
| Cayman Chemical | 20893 | Todralazine (hydrochloride) ≥98% | 3778-76-5 | 1g | $299 | 2024-03-01 | Buy |
| AK Scientific | O389 | TodralazineHCl | 3778-76-5 | 1g | $430 | 2021-12-16 | Buy |
| ChemScene | CS-0098222 | Todralazinehydrochloride 98.17% | 3778-76-5 | 50mg | $100 | 2021-12-16 | Buy |
Todralazine hydrochloride Chemical Properties,Uses,Production
Originator
Prorazin,Teisan
Uses
Todralazine Hydrochloride is an antihypertensive agent for research use. Vasodilator.
Uses
Antihypertensor
Manufacturing Process
A suspension of 13 g of hydrazinophthalazine in 500 ml of anhydrous ethanol
is cooled, under agitation to a temperature of -10°C. To the suspension is
added dropwise within 30 min a solution of 4.5 g of ethyl chlorocarbonate in
150 ml of anhydrous ethanol and the reaction mass is agitated for about 2
hours, maintaining a temperature of -10°C. The temperature is then raised to
about 20°C and stirring is continued for 2 hours, whereupon heating is applied
and boiling is maintained for 15 min. After cooling, the separated 1-
hydrazinophthalazine hydrochloride is filtered and washed with anhydrous
ethanol.
The filtrate is evaporated to a dry state under decreased pressure at a
temperature of below 50°C. The residue in a quantity of 8.5 g is dissolved in a
boiling solution of 3 ml of concentrated hydrochloric acid in 15 ml of water,
and after adding 5 ml of 90%-ethanol the solution is cooled to a temperature
of below 0°C.
The separated 1-carboethoxyhydrazinophthalazine hydrochloride is filtered and
washed with anhydrous ethanol. 11.5 g of a raw product are obtained which
for the purpose of purification are dissolved in 15 ml of boiling water with an
addition of 10 ml of 96%-ethanol and after cooling to below 0°C, the pure 1-
carboethoxyhydrazinophthalazine hydrochloride is filtered. 9.8 g of the are
obtained.
Therapeutic Function
Antihypertensive
Todralazine hydrochloride Preparation Products And Raw materials
Todralazine hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12990 | 57 | |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9664 | 60 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |