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Todralazine hydrochloride

Todralazine hydrochloride
Todralazine hydrochloride structure
Chemical Name:
Todralazine hydrochloride
binazin;binazine;apirachol;ECARAZINE;Apiracohl;Hydrapron;TODRALAZINE HCL;621-bthydrochloride;ECARAZINE HYDROCHLORIDE;TODRALAZINE HYDROCHLORIDE
Molecular Formula:
Formula Weight:
MOL File:
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3
RTECS  FE2778600
Toxicity LD50 i.p. in mice: 500 mg/kg (Parravincini)

Todralazine hydrochloride price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20893 Todralazine (hydrochloride) ≥98% 3778-76-5 250mg $68 2021-12-16 Buy
Cayman Chemical 20893 Todralazine (hydrochloride) ≥98% 3778-76-5 500mg $129 2021-12-16 Buy
ChemScene CS-0098222 Todralazinehydrochloride 98.17% 3778-76-5 100mg $150 2021-12-16 Buy
ChemScene CS-0098222 Todralazinehydrochloride 98.17% 3778-76-5 50mg $100 2021-12-16 Buy
ChemScene CS-0098222 Todralazinehydrochloride 98.17% 3778-76-5 10mg $50 2021-12-16 Buy

Todralazine hydrochloride Chemical Properties,Uses,Production






Todralazine Hydrochloride is an antihypertensive agent for research use. Vasodilator.

Manufacturing Process

A suspension of 13 g of hydrazinophthalazine in 500 ml of anhydrous ethanol is cooled, under agitation to a temperature of -10°C. To the suspension is added dropwise within 30 min a solution of 4.5 g of ethyl chlorocarbonate in 150 ml of anhydrous ethanol and the reaction mass is agitated for about 2 hours, maintaining a temperature of -10°C. The temperature is then raised to about 20°C and stirring is continued for 2 hours, whereupon heating is applied and boiling is maintained for 15 min. After cooling, the separated 1- hydrazinophthalazine hydrochloride is filtered and washed with anhydrous ethanol.
The filtrate is evaporated to a dry state under decreased pressure at a temperature of below 50°C. The residue in a quantity of 8.5 g is dissolved in a boiling solution of 3 ml of concentrated hydrochloric acid in 15 ml of water, and after adding 5 ml of 90%-ethanol the solution is cooled to a temperature of below 0°C.
The separated 1-carboethoxyhydrazinophthalazine hydrochloride is filtered and washed with anhydrous ethanol. 11.5 g of a raw product are obtained which for the purpose of purification are dissolved in 15 ml of boiling water with an addition of 10 ml of 96%-ethanol and after cooling to below 0°C, the pure 1- carboethoxyhydrazinophthalazine hydrochloride is filtered. 9.8 g of the are obtained.

Therapeutic Function


Todralazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Todralazine hydrochloride Suppliers

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BOC Sciences
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Hubei Ipure Biology Co., Ltd
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Dayang Chem (Hangzhou) Co.,Ltd.
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Syntechem Co.,Ltd Please Email
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Spectrum Chemical Manufacturing Corp. 18616765336
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BOC Sciences 16314854226 United States 21113 65
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
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Hangzhou J&H Chemical Co., Ltd. 0571-87396432-
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Shanghai EFE Biological Technology Co., Ltd. 021-65675885
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