ChemicalBook >> CAS DataBase List >>BAY-1125976.
BAY-1125976.
- CAS No.
- 1402608-02-9
- Chemical Name:
- BAY-1125976.
- Synonyms
- CS-2913;BAY1125976;BAY 1125976;BAY-1125976.;BAY-1125976; BAY 1125976;inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976;2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide;Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
- CBNumber:
- CB73133467
- Molecular Formula:
- C23H21N5O
- Molecular Weight:
- 383.45
- MDL Number:
- MFCD30481340
- MOL File:
- 1402608-02-9.mol
Last updated:2023-05-21 10:59:17
| storage temp. | Store at -20°C |
|---|---|
| solubility |
DMSO:13.0(Max Conc. mg/mL);33.9(Max Conc. mM) DMF:5.0(Max Conc. mg/mL);13.04(Max Conc. mM) DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.65(Max Conc. mM) |
| form | A crystalline solid |
| FDA UNII | ZL7A1UM87X |
BAY-1125976. price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28913 | BAY-1125976 | 1402608-02-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 28913 | BAY-1125976 | 1402608-02-9 | 25mg | $533 | 2024-03-01 | Buy |
| Cayman Chemical | 28913 | BAY-1125976 | 1402608-02-9 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 28913 | BAY-1125976 | 1402608-02-9 | 10mg | $243 | 2024-03-01 | Buy |
| AK Scientific | 2002DU | 2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide | 1402608-02-9 | 5mg | $252 | 2021-12-16 | Buy |
BAY-1125976. Chemical Properties,Uses,Production
Description
BAY-1125976 is an allosteric inhibitor of Akt1 and -2 (IC50s = 5.2 and 18 nM, respectively, in a time-resolved FRET assay). It is selective for Akt1 and -2 over Akt3 (IC50 = 427 nM in the same assay) but does inhibit the activity of the receptor tyrosine kinases FLT1, -3, -4, and Mer by greater than 50% in a panel of 227 kinases at 1 μM. BAY-1125976 inhibits the proliferation of 23 cancer cell lines (IC50s = 0.02-10 μM) and reduces tumor growth in KPL-4, MCF-7, and patient-derived xenograft (PDX) mouse models when administered at a dose of 50 mg/kg per day.
BAY-1125976. Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 51)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 2996 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 995 | 55 |
1402608-02-9(BAY-1125976.)Related Search:
BAY 1125976
BAY1125976
BAY-1125976.
2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide
BAY-1125976; BAY 1125976
CS-2913
Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976
1402608-02-9