Sephin 1
- CAS No.
- 951441-04-6
- Chemical Name:
- Sephin 1
- Synonyms
- Sephin 1;Icerguastat;lcerguastat;Sephin 1 - NSC 65390;2-[(E)-(2-chlorophenyl)methylideneamino]guanidine;(E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide;Hydrazinecarboximidamide, 2-[(2-chlorophenyl)methylene]-, (2E)-;IFB 088,Sephin1,Inhibitor,misfolding,Sephin-1,prion,Icerguastat,IFB088,stress,eIF2α,sclerosis,Phosphatase,inhibit,protein
- CBNumber:
- CB73146380
- Molecular Formula:
- C8H9ClN4
- Molecular Weight:
- 196.64
- MDL Number:
- MFCD00790608
- MOL File:
- 951441-04-6.mol
- MSDS File:
- SDS
| Boiling point | 320.9±44.0 °C(Predicted) |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (100 mM) |
| form | powder |
| pka | 8.74±0.30(Predicted) |
| color | white to beige |
| FDA UNII | 9M998304JB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P310+P330 |
| RIDADR | UN 2811 6.1 / PGIII |
Sephin 1 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1356 | Sephin1 ≥95% (HPLC) | 951441-04-6 | 10MG | $69 | 2023-06-20 | Buy |
| Tocris | 5553 | Sephin1 ≥98%(HPLC) | 951441-04-6 | 50 | $616 | 2021-12-16 | Buy |
| Axon Medchem | Axon2524 | Sephin1-NSC65390 99% | 951441-04-6 | 10mg | $60.5 | 2021-12-16 | Buy |
Sephin 1 Chemical Properties,Uses,Production
Uses
Sephin 1 is a selective inhibitor of holophosphatase, a regulatory subunit of protein phosphatase 1. May be used in the prevention of protein misfolding diseases.
Biochem/physiol Actions
Sephin1 is a selective inhibitor of a holophosphatase. It is a guanabez derivative that binds to and inhibits a regulatory subunit of the stress-induced protein phosphatase 1 (PPP1R15A), but not the constitutive PPP1R15B, and lacks α2-adrenergic activity. Phosphorylation of eIF2α, α subunit of eukaryotic translation initiation factor 2, reduces protein synthesis and prevents the accumulation of misfolded protein in the endoplasmic reticulum (ER). PPP1R15A recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate eIF2α, so inhibiting PPP1R15A activity prolongs the phosphorylation of eIF2α and aids in its prevention of the accumulation of misfolded protein. In vitro Sephin1 protected cells from lethal protein misfolding and cytotoxic ER stress. In vivo sephin1 prevented two unrelated protein misfolding diseases in mice (Charchot-Marie-Tooth 1B and ALS).
storage
+4°C
Sephin 1 Preparation Products And Raw materials
Raw materials
Preparation Products
Sephin 1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3444 | 55 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2983 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |