Talniflumate
- CAS No.
- 66898-62-2
- Chemical Name:
- Talniflumate
- Synonyms
- somalgen;ba7602-06;TALNIFLUMATE;Talniflumate, >=99%;Talniflumate (BA 7602-06);TALNIFLUMATE(INTERMEDIATE);phthalidyl2-(3-trifluoromethylanilino)nicotinate;2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid phthalidyl ester;phthalidyl2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinate;2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinicaciphthalidylester
- CBNumber:
- CB7315594
- Molecular Formula:
- C21H13F3N2O4
- Molecular Weight:
- 414.33
- MDL Number:
- MFCD00866135
- MOL File:
- 66898-62-2.mol
| Melting point | 165-167°C |
|---|---|
| Boiling point | 534.6±50.0 °C(Predicted) |
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | Chlorform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 2.72±0.10(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
| λmax | 287nm(CHCl3)(lit.) |
| Merck | 14,9044 |
| Stability | Acid Sensitive, Moisture Sensitive |
| FDA UNII | JFK78S0U9S |
SAFETY
Risk and Safety Statements
| RTECS | QT2999200 |
|---|---|
| HS Code | 2933.39.9200 |
| Toxicity | LD50 orally in rats: 12000 mg/kg (Los) |
Talniflumate price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1710 | Talniflumate ≥98% (HPLC) | 66898-62-2 | 5MG | $86 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1710 | Talniflumate ≥98% (HPLC) | 66898-62-2 | 25MG | $350 | 2024-03-01 | Buy |
| TCI Chemical | T3101 | Talniflumate >98.0%(HPLC)(N) | 66898-62-2 | 1g | $327 | 2024-03-01 | Buy |
| TCI Chemical | T3101 | Talniflumate >98.0%(HPLC)(N) | 66898-62-2 | 200mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 29623 | Talniflumate | 66898-62-2 | 5mg | $38 | 2024-03-01 | Buy |
Talniflumate Chemical Properties,Uses,Production
Chemical Properties
White to pale yellow crystalline powder
Originator
Somalgen,Bago,Argentina,1972
Uses
Anti-inflammatory; analgesic.
Uses
Talniflumate is a nonaspirin and nonsteroidal anti-inflammatory drug.
Definition
ChEBI: 2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester is a member of benzofurans.
Manufacturing Process
49 ml of triethylamine were added to a suspension of 2-(3'-
trifluoromethylanilino)nicotinic acid (70.6 g in 250 ml of dimethylformamide).
After stirring for 30 minutes 53.3 g of 3-bromophthalide were added. The
reaction mixture was maintained at 25°C to 30°C during 4 hours. Ethyl
acetate (750 ml) was poured into the reaction mixture. This solution was
filtered and extracted with water (4 x 250 ml), discarding the water layer.
The organic layer was dried with anhydrous magnesium sulfate and then
filtered. The solution was concentrated under vacuum at 30°C to 35°C until
reduced to half of its original volume and then cooled to 5°C to allow the
crystallization of the compound. Thus, the cake was filtered, washed with cool
ethyl acetate, and dried under vacuum. Yield: 74% (76.7 g) of phthalidyl
ester of 2-(3'-trifluoromethylanilino)-pyridin-3-carboxylic acid, melting point:
165°C to 167°C.
brand name
Somalgen (Laboratorio Bago, S.A., Argentina).
Therapeutic Function
Antiinflammatory, Analgesic
Biological Activity
Calcium-activated chloride channel (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl - /HCO 3 - exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
Talniflumate Preparation Products And Raw materials
Talniflumate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
View Lastest Price from Talniflumate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![(3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/24b09232-10c9-4a1d-94d2-00d95b015338.jpg) |
2020-01-10 | (3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate
66898-62-2
|
US $1.00 / KG | 1KG | 98% HPLC | 10 tons/month | Career Henan Chemical Co |
-
- (3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate
66898-62-2
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co