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Quinolinic acid

Quinolinic acid structure

CAS No.: 89-00-9

Chemical Name:: Quinolinic acid

Synonyms: PYRIDINE-2,3-DICARBOXYLIC ACID;2,3-PYRIDINEDICARBOXYLIC ACID;QUIN;2,3-Pyridinedicarboxylic;Pyridine-2,3-dicarboxylate;2,3-PyridinedicarboxylicAcid99%;109/KG;NSC 18836;NSC 13127;NSC 403247

CBNumber:: CB7316162

Molecular Formula:: C7H5NO4

Molecular Weight:: 167.12

MDL Number:: MFCD00006295

MOL File:: 89-00-9.mol

Last updated:2023-09-22 17:54:45

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Quinolinic acid Properties

Melting point	188-190 °C (dec.) (lit.)
Boiling point	295.67°C (rough estimate)
Density	1.5216 (rough estimate)
refractive index	1.6280 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	10g/l
form	Crystalline Powder
pka	2.43(at 25℃)
color	White to light yellow-beige
Odor	odorless
Water Solubility	0.55 g/100 mL
Merck	14,8073
BRN	137110
InChIKey	GJAWHXHKYYXBSV-UHFFFAOYSA-N
CAS DataBase Reference	89-00-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	F6F0HK1URN
EPA Substance Registry System	2,3-Pyridinedicarboxylic acid (89-00-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H335

Precautionary statements

P261-P264-P271-P280-P304+P340+P312-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38-33

Safety Statements

26-36/37-24/25-37

WGK Germany

RTECS

US7967250

TSCA

HazardClass

IRRITANT

HS Code

29333999

Toxicity

Focal injection of quinolinic acid into specific areas of the brain produces neuronal damage although sparing axons of passage. Similarities between the biochemical and morphological profiles of these lesions and human neuropathy seen in neurodegenerative diseases have led to the proposal that endogenous excitotoxins may play a role in such neurodegenerative disease states. Quinolinic acid is an intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals including man. The neuroexcitatory action is thought to be mediated via interaction with the N-methyl-D-aspartate (NMDA) receptor of the glutamate family. No mechanism for quinolinic acid removal, nor for synaptic inactivation, has been found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur.

NFPA 704

	0
2		0

Quinolinic acid price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P63204	2,3-Pyridinedicarboxylic acid 99%	89-00-9	25g	$31.4	2024-03-01	Buy
Sigma-Aldrich	P63204	2,3-Pyridinedicarboxylic acid 99%	89-00-9	100g	$34.8	2024-03-01	Buy
TCI Chemical	P0550	2,3-Pyridinedicarboxylic Acid >98.0%(GC)(T)	89-00-9	25g	$25	2024-03-01	Buy
TCI Chemical	P0550	2,3-Pyridinedicarboxylic Acid >98.0%(GC)(T)	89-00-9	500g	$199	2024-03-01	Buy
Alfa Aesar	A11414	Pyridine-2,3-dicarboxylic acid, 99%	89-00-9	25g	$23.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
P63204	25g	$31.4	Buy
P63204	100g	$34.8	Buy
P0550	25g	$25	Buy
P0550	500g	$199	Buy
A11414	25g	$23.65	Buy

Quinolinic acid Chemical Properties,Uses,Production

Chemical Properties

White powder;Light yellow powder

Uses

Quinolinic acid is an endogenous NMDA agonist. Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid is an ?excitotoxic? metabolite and an agonist of N-methyl-D-aspartate receptors. properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders. Quinolinic acid is a potent endogenous excitant at amino acid receptors in CNS.

Uses

A matabolite of tryptophan and a putative NMDA receptor agonist.

Uses

An inhibitor of glucose synthesis.

Uses

Inhibits glucose synthesis

Definition

ChEBI: Quinolinic acid is a pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan. It has a role as a NMDA receptor agonist, a human metabolite, a mouse metabolite and an Escherichia coli metabolite. It is a conjugate acid of a quinolinate(1-) and a quinolinate.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 3020, 1949 DOI: 10.1021/ja01177a021

Hazard

A poison by skin contact. Moderately toxic by ingestion. A mild skin irritant.

Industrial uses

The use of quinolinic acid during flotation of hematite results in the adsorption of quinoline on hematite, allowing amine to selectively adsorb onto the hematite surface.

Biological Activity

Endogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.

Safety Profile

A poison by skin contact. Moderately toxic by ingestion. Experimental reproductive effects. A mdd skinn irritant. When heated to decomposition it emits toxic vapors of NOx.

storage

Room temperature

Quinolinic acid Preparation Products And Raw materials

Raw materials

Diethyl oxalacetate Acrolein Quinoline Ethanol Dicarboxylic Acid

Potassium permanganate KZESTKDHUUMSOC-UHFFFAOYSA-N 2,3-Pyridinedicarboxylic acid copper(II) salt Diethyl pyridine-2,3-dicarboxylate 5-BROMO-8-NITROQUINOLINE

3-HYDROXYANTHRANILIC ACID 8-Quinolinesulfonyl chloride 8-Hydroxyquinoline 6-Methylquinoline 8-Aminoquinoline

2-Picolinic acid

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Preparation Products

3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID METHYL 3-CYANOPYRIDINE-2-CARBOXYLATE 3-Amino-2-pyridinecarboxylic acid 5-Methylpyridine-2,3-dicarboxylic acid 3-CARBAMOYLPICOLINIC ACID

3-AMINO-6-BROMO-PYRIDIN-2-OL 5-Methoxymethyl-2,3-pyridinedicarboxylic acid 5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione METHYL 3-(CHLOROCARBONYL)PYRIDINE-2-CARBOXYLATE HYDROCHLORIDE 3-CYANOPYRIDINE-2-CARBOXYLIC ACID

2-(AMINOCARBONYL)NICOTINIC ACID 3-(METHOXYCARBONYL)PYRIDINE-2-CARBOXYLIC ACID

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Quinolinic acid Suppliers

Global( 565)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5964	58
shandong exelon biochem co.ld	+86-533-2119995 +8615053330977	451614802@QQ.com	China	28	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	885	50
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	7838	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Guanlang Biotechnology Co,.LTD	58
shandong exelon biochem co.ld	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from Quinolinic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-19	Quinolinic acid 89-00-9	US $0.00 / kg	1kg	99%	300mt	Jinan Finer Chemical Co., Ltd
2023-09-23	2,3-Pyridinedicarboxylic acid 89-00-9	US $0.00 / kgs	1000kgs	99%	10 tons	shandong exelon biochem co.ld
2023-08-05	Quinolinic Acid 89-00-9	US $5.00-2.00 / KG	1KG	99%	10000kg	Hebei Guanlang Biotechnology Co,.LTD

Quinolinic acid
89-00-9
US $0.00 / kg
99%
Jinan Finer Chemical Co., Ltd

2,3-Pyridinedicarboxylic acid
89-00-9
US $0.00 / kgs
99%
shandong exelon biochem co.ld

Quinolinic Acid
89-00-9
US $5.00-2.00 / KG
99%
Hebei Guanlang Biotechnology Co,.LTD

Quinolinic acid Spectrum

Quinolinic acid(89-00-9)MS Quinolinic acid(89-00-9)¹HNMR Quinolinic acid(89-00-9)IR1 Quinolinic acid(89-00-9)IR2 Quinolinic acid(89-00-9)Raman Quinolinic acid(89-00-9)ESR

89-00-9(Quinolinic acid)Related Search:

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Ethoxyquin Pyridine Isoquinoline DIPIPERIDINOMETHANE

OXALIC ACID Ethyl 2-(Chlorosulfonyl)acetate Chromium picolinate 2,6-Lutidine 5,6,7,8-TETRAHYDROISOQUINOLINE

Folic acid Citric acid Glycine Ascoric Acid Quinclorac

2,5-PYRIDINEDICARBOXYLIC ACID 3,5-Pyridinedicarboxylic acid Pyridine-2,6-dicarboxylic acid

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QuinolinicAcid>99% Pyridin-2,3-dicarbonsaeure 2,3-PYRIDINEDICARBOXYLIC ACID (QUINOLINIC ACID) 2,3-pyridine dicarbo AKOS BBS-00003814 AKOS AUF2085 Quinolinic Acid 99% 2,3-Pyridinedicarboxylic acid, 99% 100GR 2,3-Pyridinedicarboxylic acid, 99% 25GR NSC 13127 NSC 18836 NSC 403247 2,3-PYRIDINEDICARBOXYLIC ACID FOR SYNTHE Pyridinecarboxylic acid-2,3- two 2,3-Pyridinedicarboxylic acid 99% 2,3-PYRIDINEDICARBOXYLIC ACID AKOS AUF2085 2,3-pyridinediacrboxylic acid Pyridine-2,3-dicarboxylic acid (quinolinic acid) 109/KG 2,3-Pyridinedicarboxylic acid Vetec(TM) reagent grade, 98% RARECHEM AL BO 0810 QUINOLIC ACID QUINOLINIC ACID 2,3 PYRIDINE DICARBOXYLIC ACID (AS PER INVOICE AND PACKING LIST) PYRIDINE-2,3-DICARBOXYLI ACID 2,3-PyridinedicarboxylicAcid> Pyridine-2,3-Dicarboxylic Acid,99%, 2,3-PyridinedicarboxyL 2,3-PyridinedicarboxylicAcid99% 2,3-Pyridinedicarboxylic 2,3-PYRIDINEDICARBOXYLIC ACID PYRIDINE-2,3-DICARBOXYLIC ACID Pyridine-2,3-dicarboxylate QUIN Quinolinic acid (2,3-pyridinedihydroxy acid) Pyridine Dicarbonylic Acid 89-00-9 98-00-9 Building Blocks C7 and C8 CARBOXYLIC ACID Pyridines Quinolines Heterocyclic Building Blocks Pyridine series Pyridine pyridine derivative Carboxylic Acids Pyridines Heterocyclic Compounds Heterocycles Inhibitors Carboxylic Acids Medical Intermediates Aromatics Intermediates & Fine Chemicals Pharmaceuticals Pesticides intermediate