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AMG-3969

AMG-3969 structure

CAS No.: 1361224-53-4

Chemical Name:: AMG-3969

Synonyms: CS-2503;AMG-3969;AMG-3969; AMG 3969; AMG3969;Hexokinase IV,AMG 3969,Hexokinase D,Glucokinase,Inhibitor,AMG3969,AMG-3969,inhibit;2-[4-[(2S)-4-[(6-amino-3-pyridyl)sulfonyl]-2-prop-1-ynyl-piperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol;Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)-;Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)-;(S)-2-(4-(4-((6-Aminopyridin-3-yl)sulfonyl)-2-(prop-1-yn-1-yl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

CBNumber:: CB73166063

Molecular Formula:: C21H20F6N4O3S

Molecular Weight:: 522.46

MDL Number:: MFCD28386194

MOL File:: 1361224-53-4.mol

Last updated:2023-05-18 11:31:07

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AMG-3969 Properties

Boiling point	648.8±65.0 °C(Predicted)
Density	1.56±0.1 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	DMSO:100.0(Max Conc. mg/mL);191.4(Max Conc. mM)
pka	10.12±0.15(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2935909099

AMG-3969 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-6243	AMG-3969 99.74%	1361224-53-4	5mg	$420	2021-12-16	Buy
Apolloscientific	BISN0048	AMG-3969 99%	1361224-53-4	5mg	$522	2021-12-16	Buy
ChemScene	CS-6243	AMG-3969 99.74%	1361224-53-4	10mg	$600	2021-12-16	Buy
Apolloscientific	BISN0048	AMG-3969 99%	1361224-53-4	10mg	$747	2021-12-16	Buy
ChemScene	CS-6243	AMG-3969 99.74%	1361224-53-4	1mg	$180	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-6243	5mg	$420	Buy
BISN0048	5mg	$522	Buy
CS-6243	10mg	$600	Buy
BISN0048	10mg	$747	Buy
CS-6243	1mg	$180	Buy

AMG-3969 Chemical Properties,Uses,Production

Description

AMG-3969is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor. Itcan strongly boost the dissociation of the GK-GKRP complex and promote GK translocation in-vivo. In rodent model of diabetes, AMG-3969 reduces blood glucose levels without affecting euglycemic animals. It is a promising drug for the treatment of type II diabetes through lowering blood glucose levels with reduced potential for hypoglycaemic risk.

References

Lloyd, David J., et al. "Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors." Nature 504.7480(2013):437-40.
Bourbeau, M. P., et al. "Nonracemic synthesis of GK-GKRP disruptor AMG-3969. " Synfacts 79.8(2014):3684.
http://www.metonchem.com/products/amg-3969-cas1361224-53-4/

AMG-3969 Preparation Products And Raw materials

Raw materials

Preparation Products

AMG-3969 Suppliers

Global( 60)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Chengdu Henghui Pharm Tec Co. Ltd.	13540674322 15828370308		CHINA	121	55
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4647	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
Chengdu Henghui Pharm Tec Co. Ltd.	55
Shanghai Boyle Chemical Co., Ltd.	55
Dalian Meilun Biotech Co., Ltd.	58

AMG-3969 CS-2503 AMG-3969; AMG 3969; AMG3969 Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)- Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)- (S)-2-(4-(4-((6-Aminopyridin-3-yl)sulfonyl)-2-(prop-1-yn-1-yl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol Hexokinase IV,AMG 3969,Hexokinase D,Glucokinase,Inhibitor,AMG3969,AMG-3969,inhibit 2-[4-[(2S)-4-[(6-amino-3-pyridyl)sulfonyl]-2-prop-1-ynyl-piperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol 1361224-53-4 C21H20F6N4O3S