METICRANE
- CAS No.
- 1084-65-7
- Chemical Name:
- METICRANE
- Synonyms
- COL4A1;e-103-e;SD 17102;Arresten;fontiliz;meticran;SD-171-02;METICRANE;Collagen α-1(IV) chain;6-methyl-7-sulfamido-thiochroman-1,1-dioxide
- CBNumber:
- CB7331774
- Molecular Formula:
- C10H13NO4S2
- Molecular Weight:
- 275.34
- MDL Number:
- MFCD00079454
- MOL File:
- 1084-65-7.mol
- MSDS File:
- SDS
| Melting point | 236-237° |
|---|---|
| Boiling point | 549.1±60.0 °C(Predicted) |
| Density | 1.4366 (rough estimate) |
| refractive index | 1.6800 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | ≥ 12.45mg/mL in DMSO |
| pka | 9.71±0.20(Predicted) |
| FDA UNII | I7EKN1924Q |
| ATC code | C03BA09 |
| EPA Substance Registry System | 2H-1-Benzothiopyran-7-sulfonamide, 3,4-dihydro-6-methyl-, 1,1-dioxide (1084-65-7) |
SAFETY
Risk and Safety Statements
| WGK Germany | 2 |
|---|---|
| RTECS | XK6360000 |
| Toxicity | mouse,LD50,intraperitoneal,10gm/kg (10000mg/kg),Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 217, 1974. |
METICRANE price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M6902 | Meticrane analytical standard | 1084-65-7 | 5g | $89.5 | 2022-05-15 | Buy |
| Usbiological | 354904 | COL4A1 | 1084-65-7 | 48Tests | $588 | 2021-12-16 | Buy |
| Usbiological | 354903 | COL4A1 | 1084-65-7 | 48Tests | $588 | 2021-12-16 | Buy |
| Usbiological | 382459 | COL4a1 | 1084-65-7 | 96Tests | $729 | 2021-12-16 | Buy |
| Usbiological | 382458 | COL4a1 | 1084-65-7 | 96Tests | $729 | 2021-12-16 | Buy |
METICRANE Chemical Properties,Uses,Production
Originator
Fontilix,Diamant
Uses
diuretic, antihypertensive
Definition
ChEBI: Meticrane is a thiochromane.
Manufacturing Process
64.5 g of 6-methylthiachromane were dissolved in 500 ml of acetic acid and
250 ml of 110-volume hydrogen peroxide were added. The solution was
placed on a water bath for 1.5 hour; it was then diluted with iced water, the
precipitate obtained was recovered, and this was washed and dried. There
were obtained 59.6 g of 6-methylthiachromane-1,1-dioxide (yield: 77.5%;
melting point 79°-81°C).
52 g of this product were added to 250 ml of chlorosulfonic acid and the
mixture was placed on a water bath at a temperature of 70°-75°C for 2
hours. It was allowed to cool and poured onto crushed ice; the product was
extracted by means of chloroform, the extracted solutions were washed and
the chloroform was evaporated. There were obtained 67 g of crude 6-methyl-
7-chloro-sulfonyl-thiachromane-1,1-dioxide (yield: 86%; melting point 158°-
161°C).
47 g of this sulfochloride were introduced into 200 ml of liquid ammonia. The
mixture was left to stand at ambient temperature until the ammonia
evaporated. The residue was taken up in water and the solution was acidified.
The precipitate formed was centrifuged, washed with water and dried. There
were obtained 30.8 g of 6-methyl-7-sulfamido-thiachromane-1,1-dioxide,
recrystallized from 2-methoxy ethanol (yield: 49%; MP: 236°-237°C).
Therapeutic Function
Diuretic
METICRANE Preparation Products And Raw materials
METICRANE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
View Lastest Price from METICRANE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | 6-methyl-1,1-dioxo-3,4-dihydro-2H-thiochromene-7-sulfonamide
1084-65-7
|
US $9.80 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- 6-methyl-1,1-dioxo-3,4-dihydro-2H-thiochromene-7-sulfonamide
1084-65-7
- US $9.80 / KG
- ≥98%
- Career Henan Chemical Co