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Sulfadimethoxine

CAS No.
122-11-2
Chemical Name:
Sulfadimethoxine
Synonyms
SULPHADIMETHOXINE;Sulfadimethoxine base;sulfadimethoxin;symbio;sulfadimetoxin;abcid;albon;fuxal;sudine;Dosmin
CBNumber:
CB7333026
Molecular Formula:
C12H14N4O4S
Molecular Weight:
310.33
MDL Number:
MFCD00057345
MOL File:
122-11-2.mol
MSDS File:
SDS
Last updated:2023-06-27 17:36:02

Sulfadimethoxine Properties

Melting point 200 °C
Boiling point 265.5°C (rough estimate)
Density 1.4006 (rough estimate)
refractive index 1.6270 (estimate)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility NH4OH 1 M: 50 mg/mL, clear, faintly yellow
pka pKa 5.94(H2O t = 25.0±0.5 I = 0.2) (Uncertain)
color White to Off-White
Water Solubility 46.3mg/L(37 ºC)
Merck 14,8905
BRN 306856
CAS DataBase Reference 122-11-2(CAS DataBase Reference)
FDA 21 CFR 556.640; 558.4
FDA UNII 30CPC5LDEX
ATC code J01ED01
EPA Substance Registry System Sulfadimethoxine (122-11-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xi
Risk Statements  36/37/38-43
Safety Statements  26-36/37-24/25-23
RIDADR  3249
WGK Germany  3
RTECS  WO9030000
8
HazardClass  6.1(b)
PackingGroup  III
HS Code  29350090
Toxicity LD50 orally in mice: >10 g/kg (Seki)
NFPA 704
0
2 0

Sulfadimethoxine price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1448 Sulfadimethoxine Pharmaceutical Secondary Standard; Certified Reference Material 122-11-2 500mg $105 2024-03-01 Buy
Sigma-Aldrich 1626001 Sulfadimethoxine United States Pharmacopeia (USP) Reference Standard 122-11-2 200mg $228.6 2024-03-01 Buy
TCI Chemical S0359 Sulfadimethoxine >98.0%(HPLC)(T) 122-11-2 25g $81 2024-03-01 Buy
Cayman Chemical 28827 Sulfadimethoxine 122-11-2 25g $70 2024-03-01 Buy
Cayman Chemical 28827 Sulfadimethoxine 122-11-2 50g $109 2024-03-01 Buy
Product number Packaging Price Buy
PHR1448 500mg $105 Buy
1626001 200mg $228.6 Buy
S0359 25g $81 Buy
28827 25g $70 Buy
28827 50g $109 Buy

Sulfadimethoxine Chemical Properties,Uses,Production

Brand Name(s) in US

Albon, Bactrovet, and generic

Chemical Properties

White Solid

Originator

Madribon,Roche,US,1958

Uses

Antibacterial.This compound is a contaminant of emerging concern (CECs).

Definition

ChEBI: A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.

Manufacturing Process

1.4 g of 4-phenylsulfonyl-2,6-dimethoxypyrimidine and 4 g of sodium sulfanilamide (both dried over potassium hydroxide) were very finely ground and heated in an oil bath for 10 hours at 120°C (inside temperature). The reaction mixture was taken up in 30 ml of water and treated with 3 ml of 2 N sodium hydroxide solution. After standing for one hour at 0°C, the turbid solution was filtered and the filtrate was made alkaline with sodium carbonate. After again standing for one hour at 0°C, the precipitate was filtered off (1.9 g of regenerated sulfanilamide) and the filtrate was neutralized with acetic acid, whereupon crystallization resulted. The isolated crystals of 4-sulfanilamido- 2,6-dimethoxypyrimidine weighed 1.3 g (84% of theory), melting point 190°C to 196°C.

Therapeutic Function

Antibacterial

Pharmaceutical Applications

2,4-Dimethoxy-6-sulfanilamido-1,3-diazine. A rapidly absorbed compound with a long half-life (38–40 h) and a high degree of protein binding (98%). Renal clearance is very slow, and daily dosage maintains adequate plasma levels.

Safety Profile

Moderately toxic by intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

Veterinary Drugs and Treatments

Sulfadimethoxine injection and tablets are approved for use in dogs and cats for respiratory, genitourinary, enteric and soft tissue infections caused by susceptible organisms. Sulfadimethoxine is used in the treatment of coccidiosis in dogs although not approved for this indication.
In horses, sulfadimethoxine injection is approved for the treatment of respiratory infections caused by Streptococcus equi.
In cattle, the drug is approved for treating shipping fever complex, calf diphtheria, bacterial pneumonia and foot rot caused by susceptible organisms.
In poultry, sulfadimethoxine is added to drinking water to treat coccidiosis, fowl cholera, and infectious coryza.

555-25-9
122-11-2
Synthesis of Sulfadimethoxine from 4-(Acetylamino)-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide

Sulfadimethoxine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 327)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Fortuna Chemical Co., Ltd
+86-27-59207850 +86-13986145403 info@fortunachem.com China 5981 58
Hebei Guanlang Biotechnology Co,.LTD
+8619930503252 daisy@crovellbio.com China 5966 58
Changzhou Rokechem Technology Co., Ltd.
18758118018 sales001@rokechem.com China 255 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 +8613734021967 kaia@neputrading.com China 1011 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-81148696 +8615536356810 1047@dideu.com China 3984 58

View Lastest Price from Sulfadimethoxine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sulfadimethoxine pictures 2023-08-16 Sulfadimethoxine
122-11-2
US $80.00 / KG 1KG >99% 20tons Weijer International Trade (Hebei) Co., Ltd
Sulfadimethoxine pictures 2023-06-28 Sulfadimethoxine
122-11-2
US $0.00-0.00 / Kg 1Kg 99%;USP/EP/CP 1-10000kgs Changzhou Rokechem Technology Co., Ltd.
Sulfadimethoxine pictures 2023-06-22 Sulfadimethoxine
122-11-2
US $5.00-2.00 / KG 1KG 99% 10000kg Hebei Guanlang Biotechnology Co,.LTD
  • Sulfadimethoxine pictures
  • Sulfadimethoxine
    122-11-2
  • US $80.00 / KG
  • >99%
  • Weijer International Trade (Hebei) Co., Ltd
  • Sulfadimethoxine pictures
  • Sulfadimethoxine
    122-11-2
  • US $0.00-0.00 / Kg
  • 99%;USP/EP/CP
  • Changzhou Rokechem Technology Co., Ltd.
  • Sulfadimethoxine pictures
  • Sulfadimethoxine
    122-11-2
  • US $5.00-2.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co,.LTD
deposul diasulfa madroxin madroxine maxulvet memcozine metoxidon n(sup1)-(2,6-dimethoxy-4-pyrimidinyl)-sulfanilamid n(sup1)-(2,6-dimethoxy-4-pyrimidinyl)sulfanilamide neostrepal omnibon persulfen radonin redifal roscosulf scandisil sudine sulfadimethoxydiazine sulfadimetossina sulfastop sulfoplan Sulphanyl acid N-(2,6-dimethoxypyrimidin-4-yl) amide 2,4-Dimethoxy-6-sulfanilamido-1,3-pyrimidine 4-(p-Aminobenzenesulfonamido)-2,6-dimethoxypyrimidine 4-Sulfa-2,6-dimethoxypyrimidine 6-Sulfanilamido-2,4-dimethoxy-1,3-diazine Dosmin Lastin Sulfadimethoxine (200 mg)G0D2490.998mg/mg(ai) Sulfadimethoxine (200 mg) SULPHADIMETHOXINE BP 88,USP 25 Sulfadimethoxine (base and/or unspecified salts) 4-azanyl-N-(2,6-dimethoxypyrimidin-4-yl)benzenesulfonamide Sulfadimethoxine Solution, 100ppm Sulfadimethoxine solution,1000ppm Sulfadimethoxine for peak identification 2,4-dimethoxy-6-sulfanilamido-1,3-diazine 2,6-dimethoxy-4-(p-aminobenzenesulfonamido)pyrimidine 2,6-dimethoxy-4-sulfanilamidopyrimidine 4-amino-n-(2,6-dimethoxy-4-pyrimidinyl)-benzenesulfonamid abcid agribon albon arnosulfan bactrovet diasulfyl dimetazina dimethoxysulfadiazine dorisul fuxal madribon madrigid madriqid sulxin dinosol SULFADIMETHOXINE LABOTEST-BB LT00772297 4-AMINO-N-(2,6-DIMETHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE