ABH hydrochloride
- CAS No.
- 194656-75-2
- Chemical Name:
- ABH hydrochloride
- Synonyms
- ABH HCl;ABH hydrochloride;Methsuximide Impurity 1-d5;ABH hydrochloride >=98% (HPLC)
- CBNumber:
- CB73335515
- Molecular Formula:
- C6H15BClNO4
- Molecular Weight:
- 211.45
- MDL Number:
- MFCD22887376
- MOL File:
- 194656-75-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| ABH hydrochloride ≥98% (HPLC) | SML1466 | 5mg | $195 |
| ABH hydrochloride ≥98% (HPLC) | SML1466 | 25mg | $742 |
ABH hydrochloride price More Price(2)
ABH hydrochloride Chemical Properties,Uses,Production
Uses
ABH (hydrochloride) is an orally active arginase inhibitor (Ki = 8.5 nM). ABH hydrochloride promotes NO production and reduces the expression of inflammatory response-related molecules (ICAM-1, VCAM-1, MCP-1). ABH hydrochloride improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis[1][2][3][4][5][6][7][8][9][10][11].
Biochem/physiol Actions
Selective inhibition of arginase by ABH in animal models is known to ameliorate the effect of diabetes mellitus type 1, autoimmune encephalitis, chronic asthma and vascular stiffness due to aging. ABH inhibition of arginase restores erectile hemodynamics in aging mouse. Ex vivo studies prove that ABH promotes smooth muscle relaxation stimulated by nitric oxide.
in vivo
ABH (400 μg/day; p.o.; once daily; 25 days) hydrochloride can reduce arginase activity in the penile tissue of aged rats, improve erectile function, and make erectile hemodynamic indicators close to the level of young rats[4].
ABH (0.1 mM, 0.1 mL; topical application; once every 8 hours; 14 days) hydrochloride can significantly promote wound healing in mice[5].
ABH (5 mg/kg; s.c.; once 1 hour before surgery; single administration) hydrochloride can increase plasma nitrite levels in rats with pneumoperitoneum, maintain nitric oxide synthase (NOS) activity, reduce oxidative stress and inflammatory response, and reduce the severity of lung injury[6].
ABH (10 mg/kg; p.o., drinking water; once daily) hydrochloride can inhibit the increase of arginase activity and A1 expression in vascular endothelial cells of obese mice induced by a high-fat and high-sugar diet, reduce inflammation and pathological remodeling of visceral adipose tissue (VAT), including reducing inflammatory monocyte infiltration, macrophage polarization to M1 type, improving adipocyte size, fibrosis and capillary density[7].
ABH (100 mg; i.p.; once at 24, 48, 60, 70 h after infection or continuously administered until day 3 after infection) hydrochloride can increase NO production in the lungs of mice infected with Pseudomonas aeruginosa, improve L-arginine availability, reduce L-ornithine concentration, and do not increase the levels of lung inflammatory markers[8].
ABH (400 μg/kg/day; subcutaneous osmotic pump injection; once/day; 21 days) hydrochloride can reduce the mean arterial blood pressure and improve the vascular reactivity of the carotid and femoral arteries in a rat model of hypertension induced by chronic intermittent hypoxia (CIH)[9].
ABH (10 mg/kg/day; drinking water administration; continuous administration; 6 months) hydrochloride can improve endothelial function, reduce aortic stiffness and fibrosis, and reduce plasma and aortic arginase activities in a mouse model of obesity-related type 2 diabetes induced by a high-fat and high-sugar diet[10].
ABH (400 μg/day; subcutaneous osmotic pump administration; continuous administration) hydrochloride can preserve the total volume of the fetal lung, prevent excessive proliferation of pulmonary vascular smooth muscle cells, and improve the number of pulmonary vessels and lung morphology in a rat model of congenital diaphragmatic hernia (CDH) induced by Nitrofen (HY-B1877)[11].
| Animal Model: | 9-11 weeks old, male C57BL/6 mice, full-thickness dorsal excisional wound model[5] |
| Dosage: | 0.1 mM in saline |
| Administration: | Topical application, every 8 hours for 14 days |
| Result: | Accelerated wound closure 7-14 days post-surgery. Increased wound granulation tissue and decreased connective tissue on postoperative day 3. Enhanced re-epithelialization and changed the localization of myofibroblasts on postoperative day 7. Increased NOx levels in the wound on day 3. |
References
[1] Vadon-Legoff S, et al. Improved and high yield synthesis of the potent arginase inhibitor: 2 (S)-amino-6-boronohexanoic acid. Organic process research & development, 2005, 9(5): 677-679
[2] Wang L, et al. Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia. Microvasc Res. 2015 Mar;98:1-8. DOI:10.1016/j.mvr.2014.11.002
[3] Tsai P, et al. Effect of the mammalian arginase inhibitor 2(S)-amino-6-boronohexanoic acid on Bacillus anthracis arginase. Curr Microbiol. 2012 Apr;64(4):379-84. DOI:10.1007/s00284-012-0084-9
[4] Segal R, et al. Chronic oral administration of the arginase inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) improves erectile function in aged rats. J Androl. 2012 Nov-Dec;33(6):1169-75. DOI:10.2164/jandrol.111.015834
[5] Kavalukas SL, et al. Arginase inhibition promotes wound healing in mice. Surgery. 2012 Feb;151(2):287-95. DOI:10.1016/j.surg.2011.07.012
[6] Cho JS, et al. The effects of arginase inhibitor on lung oxidative stress and inflammation caused by pneumoperitoneum in rats. BMC Anesthesiol. 2015 Sep 28;15:129. DOI:10.1186/s12871-015-0112-y
[7] Yao L, et al. Obesity-induced vascular inflammation involves elevated arginase activity. Am J Physiol Regul Integr Comp Physiol. 2017 Nov 1;313(5):R560-R571. DOI:10.1152/ajpregu.00529.2016
[8] Mehl A, et al. Effect of arginase inhibition on pulmonary L-arginine metabolism in murine Pseudomonas pneumonia. PLoS One. 2014 Mar 3;9(3):e90232. DOI:10.1371/journal.pone.0090232
[9] Krause BJ, et al. Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition. Front Physiol. 2018 Jul 24;9:901. DOI:10.3389/fphys.2018.00901
[10] Bhatta A. Involvement of arginase upregulation in diabetes-and angiotensin II-induced vascular dysfunction. 2015.
[11] Toso A, et al. Congenital diaphragmatic hernia: phosphodiesterase-5 and Arginase inhibitors prevent pulmonary vascular hypoplasia in rat lungs. Pediatr Res. 2024 Mar;95(4):941-948. DOI:10.1038/s41390-022-02366-4
ABH hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
ABH hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19962 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44893 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29784 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-025-66113011 18626450290 | cb5@aikonchem.com | China | 10358 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | 2851167782@qq.com | China | 11146 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
View Lastest Price from ABH hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-10-27 | ABH Hydrochloride
194656-75-2
|
US $1980.00-2500.00 / mg | 10g | TargetMol Chemicals Inc. |
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- ABH Hydrochloride
194656-75-2
- US $1980.00-2500.00 / mg
- TargetMol Chemicals Inc.
