ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN
- CAS No.
- Chemical Name:
- ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN
- Synonyms
- ANTI-DREBRIN;ANTI-DREBRIN, HUMAN;Anti-Drebrin antibody produced in rabbit;ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN
- CBNumber:
- CB7334548
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03845304
- MOL File:
- Mol file
ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN Chemical Properties,Uses,Production
General Description
Drebrin is a member of the newly identified ADF-H family of actin-binding proteins that share the structurally conserved actin-depolymerizing factor (ADF) binding module. It is composed of a single ADF-H domain at its N-terminus, followed by a non-conserved central region and a C-terminal SH3 domain. Three isoforms, E1 and E2 (embryonic) and A (adult), have been identified in the brain. An additional truncated form of drebrin A, s-drebrin/A2, is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites.
Biochem/physiol Actions
Drebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. It colocalizes with actin filaments and dendritic-like cell processes and may be involved in actin remodeling. It binds to and dissociates F-actin stabilizing proteins such as α-actinin, fascin, and tropomyosin from actin filaments. It plays an important role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the adult brain.
ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai guandao biology engineering co., ltd | 18818239863 18818239863 | 3171921642@qq.com | China | 8884 | 58 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
| Shanghai guandao biology engineering co., ltd | 58 |