BAY-598(S-isomer)
- CAS No.
- 1906919-67-2
- Chemical Name:
- BAY-598(S-isomer)
- Synonyms
- CS-2678;CPD1616;BAY-598;(S)-BAY-598;BAY-598 (BAY598;BAY-598(S-isomer);BAY-598,Inhibitor,BAY598,inhibit,Histone Methyltransferase,BAY 598;(S)-N-(1-(N-Cyano-N'-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl)-N-ethyl-2-hydroxyacetamide;(S)-N-(1-(N-Cyano-N'-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl)-N-ethyl-2-hydroxyacetamide;N-[(4S)-1-[(Cyanoamino)[[3-(difluoromethoxy)phenyl]imino]methyl]-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxyacetamide
- CBNumber:
- CB73364108
- Molecular Formula:
- C22H20Cl2F2N6O3
- Molecular Weight:
- 525.34
- MDL Number:
- MFCD31726166
- MOL File:
- 1906919-67-2.mol
| Boiling point | 663.5±65.0 °C(Predicted) |
|---|---|
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility |
DMSO:69.18(Max Conc. mg/mL);131.69(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);57.11(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);57.11(Max Conc. mM) |
| form | powder |
| pka | 13.34±0.10(Predicted) |
| color | white to beige |
| optical activity | [α]/D -85 to -95°, c = 1 in methanol |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Symbol(GHS) | GHS07 |
| Signal word | Warning |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Precautionary statements | P301+P312+P330 |
BAY-598(S-isomer) price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1603 | BAY-598 ≥98% (HPLC) | 5MG | $125.2 | 2024-03-01 | Buy | |
| Sigma-Aldrich | SML1603 | BAY-598 ≥98% (HPLC) | 25MG | $585.6 | 2024-03-01 | Buy | |
| Cayman Chemical | 18238 | BAY 598 ≥98% | 1906919-67-2 | 500μg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 18238 | BAY 598 ≥98% | 1906919-67-2 | 1mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 18238 | BAY 598 ≥98% | 1906919-67-2 | 5mg | $266 | 2024-03-01 | Buy |
BAY-598(S-isomer) Chemical Properties,Uses,Production
Uses
BAY-598 is an aminopyrazoline-based novel substrate-competitive inhibitor of protein lysine methyltransferase SMYD2 that serves as potent and selective in vivo probe for SMYD2.
Biochem/physiol Actions
BAY-598 is a potent, peptide-competitive chemical probe for SET and MYND domain-containing protein 2 (SMYD2), a lysine methyl transferase inhibitor that dimethylates histone H3K36 and methylates histone H3K4. SMYD2 also methylates Lys-370 of p53, leading to decreased DNA-binding activity. SMYD2 is over-expressed in several cancers with poor prognosis. BAY-598 inhibits in vitro methylation of p53K370 with an IC50 value of 27 nM and in cells with an IC50 value < 1 μM. BAY-598 is more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. BAY-598 can be used with in vivo experiments. For full characterization details, please visit the BAY-598 probe summary on the Structural Genomics Consortium (SGC) website.BAY-369 is the negative control for the active probe, BAY-598. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
storage
Store at -20°C
BAY-598(S-isomer) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4647 | 58 |