Atropine sulfate monohydrate
- CAS No.
- 5908-99-6
- Chemical Name:
- Atropine sulfate monohydrate
- Synonyms
- ATRAZINE;HYOSCYAMINE SULFATE;α-(hydroxymethyl)-benzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate, hydrate (2:1:1);Atropt;Atropsiol;TROPINI SULFAS;AtropineSulfat;ATROPINI SULFAS;atropiniumsulfat;racemic anisodamine
- CBNumber:
- CB7339477
- Molecular Formula:
- C17H25NO7S
- Molecular Weight:
- 387.45
- MDL Number:
- MFCD00074815
- MOL File:
- 5908-99-6.mol
| Melting point | 189-192 °C (A)(lit.) |
|---|---|
| alpha | -0.6 º (per USP 25 ºC) |
| storage temp. | Poison room |
| solubility | H2O: soluble2.5g/mL (stable for several days at 4°C.) |
| form | Powder |
| color | white |
| Water Solubility | soluble |
| Sensitive | Light Sensitive |
| Merck | 14,875 |
| BRN | 6109275 |
| Stability | Hygroscopic |
| LogP | 2.137 (est) |
| FDA 21 CFR | 310.545 |
| CAS DataBase Reference | 5908-99-6(CAS DataBase Reference) |
| FDA UNII | 03J5ZE7KA5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H330 | |||||||||
| Precautionary statements | P301+P310+P330-P304+P340+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/28-43-36/37/38 | |||||||||
| Safety Statements | 23-45-36/37/39-26-1-25 | |||||||||
| RIDADR | UN 1544 6.1/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | CK2455000 | |||||||||
| F | 3-8-10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29399900 | |||||||||
| NFPA 704 |
|
Atropine sulfate monohydrate price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A0257 | Atropine sulfate salt monohydrate ≥97% (TLC), crystalline | 5908-99-6 | 5g | $110 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1045009 | Atropine sulfate United States Pharmacopeia (USP) Reference Standard | 5908-99-6 | 500mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP023 | Atropine sulfate British Pharmacopoeia (BP) Reference Standard | 5908-99-6 | 200MG | $320 | 2023-06-20 | Buy |
| Alfa Aesar | A10236 | Atropine sulfate monohydrate, 98+% | 5908-99-6 | 10g | $64 | 2023-06-20 | Buy |
| Alfa Aesar | A10236 | Atropine sulfate monohydrate, 98+% | 5908-99-6 | 50g | $232 | 2023-06-20 | Buy |
Atropine sulfate monohydrate Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
mydriatic and anticholinergie agent in ophthalmie preparations and pre-anesthetie medications; antidote to organophosphous insecticides
Uses
Anticholinergic;Muscarinic antagonist
Uses
Atropine sulfate is mydriatic; antispasmodic; used in preanesthetic medication.
Application
Atropine sulfate monohydrate is an alkaloid derived from belladonna, a cholinergic receptor antagonist drug, which has been shown to be a competitive non-selective antagonist of central and peripheral mAChR M (muscarinic acetylcholine receptor). It can be used in the treatment of cardiac arrhythmias. Atropine Sulfate is also used as a pharmaceutical reference standard for a variety of analytical applications.
Application
brand name
Atrophate [Veterinary] (Schering-Plough Animal Health); Atropisol (Ciba Vision, US Ophthalmics); Isopto Atropine (Alcon).
General Description
Atropine is isolated from Atropa belladonna, Datura stramonium and Mandragora officinarum. It is a tertiary amine, which acts as a cholinergic receptor antagonist.
Biological Activity
atropine is a competitive antagonist of muscarinic acetylcholine receptor with ic50 values of 2.22±0.60nm, 4.32±1.63nm, 4.16±1.04nm, 2.38±1.07nm and 3.39±1.16nm for m1, m2, m3, m4 and m5, respectively [1].atropine is an antimuscarinic agent and has shown the pharmacological effects because of binding to muscarinic acetylcholine receptors. atropine, the orthosteric antagonist, has been reported to compete with [3h]-nms for all muscarinic subtypes with a potency consistent with the high affinities at the machr subtypes. the ki values are 1.27±0.36nm, 3.24±1.16nm, 2.21±0.53nm, 0.77±0.43nm and 2.84±0.84nm, respectively [1, 2, 3].
References
[1] lebois ep1, bridges tm, lewis lm, dawson es, kane as, xiang z, jadhav sb, yin h, kennedy jp, meiler j, niswender cm, jones ck, conn pj, weaver cd, lindsley cw. discovery and characterization of novel subtype-selective allosteric agonists for the investigation of m(1) receptor function in the central nervous system.acs chem neurosci. 2010;1(2):104-121.
[2] busch h, allen h, anderson dc.effects of atropine and carbachol on labeling of protein fractions of mouse pancreas in vitro.j pharmacol exp ther. 1959 nov; 127:200-4.
[3] feron o1, smith tw, michel t, kelly ra.dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. j biol chem. 1997 jul 11; 272(28):17744-8.
Atropine sulfate monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
View Lastest Price from Atropine sulfate monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | Belladonna Extract | US $0.00-0.00 / kg | 1kg | 12%; 40% HPLC | no limitation | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-04-23 | Atropine sulfate monohydrate
5908-99-6
|
US $0.00-0.00 / kg | 1kg | ≥98% HPLC | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-03-16 | Atropine sulfate monohydrate
5908-99-6
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD |
-
- Belladonna Extract
- US $0.00-0.00 / kg
- 12%; 40% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Atropine sulfate monohydrate
5908-99-6
- US $0.00-0.00 / kg
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Atropine sulfate monohydrate
5908-99-6
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
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