Vincamine
- CAS No.
- 1617-90-9
- Chemical Name:
- Vincamine
- Synonyms
- Vinca;Vraap;Perval;Equipur;Minorin;Monorin;Novicet;Pervone;Oxybral;Angiopac
- CBNumber:
- CB7344925
- Molecular Formula:
- C21H26N2O3
- Molecular Weight:
- 354.44
- MDL Number:
- MFCD00078054
- MOL File:
- 1617-90-9.mol
- MSDS File:
- SDS
| Melting point | 232 °C (dec.)(lit.) |
|---|---|
| Boiling point | 487.66°C (rough estimate) |
| alpha | 42.8 º (c=1 in pyridine) |
| Density | 1.1640 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| pka | 12.13±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| optical activity | [α]23/D +42.8°, c = 1 in pyridine |
| Merck | 14,9983 |
| Stability | Hygroscopic |
| LogP | 3.100 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | 996XVD0JHT |
| ATC code | C04AX07 |
| NIST Chemistry Reference | Vincamine(1617-90-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YY8575000 | |||||||||
| HS Code | 29399990 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 75 i.v.; >1000 s.c. (Szporny, Szász); 1000 orally (Szabo, Nagy) | |||||||||
| NFPA 704 |
|
Vincamine price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0002124 | Vincamine European Pharmacopoeia (EP) Reference Standard | 1617-90-9 | Y0002124 | $150 | 2024-03-01 | Buy |
| Sigma-Aldrich | 75778 | Vincamine analytical standard | 1617-90-9 | 50mg | $108 | 2022-05-15 | Buy |
| TCI Chemical | V0061 | Vincamine >98.0%(T) | 1617-90-9 | 1g | $84 | 2024-03-01 | Buy |
| TCI Chemical | V0061 | Vincamine >98.0%(T) | 1617-90-9 | 5g | $281 | 2024-03-01 | Buy |
| Alfa Aesar | J60545 | Vincamine 98% | 1617-90-9 | 1g | $103 | 2023-06-20 | Buy |
Vincamine Chemical Properties,Uses,Production
Chemical Properties
white to almost white fine crystalline powder
Originator
Pervancamine ,Dausse,France,1969
Uses
Vincamine is often used as a nootropic agent to combat the effects of aging, or in conjunction with other nootropics (such as piracetam) for a variety of purposes. Vincamine is a peripheral vasodilator that increases blood flow to the brain.
Definition
ChEBI: Vincamine is a vinca alkaloid, an alkaloid ester, an organic heteropentacyclic compound, a methyl ester and a hemiaminal. It has a role as an antihypertensive agent, a vasodilator agent and a metabolite. It is functionally related to an eburnamenine.
Manufacturing Process
The following route is described in US Patent 4,145,552: At ambient temperature, over a period of thirty minutes, a solution of 33.8g (0.1mol) of (-)-vincadiformine in a mixture of 140 ml of anhydrous dimethylformamide and 140 ml of anhydrous toluene is added to a suspension of 2.64 g (0.11 mol) of sodium hydride in a mixture of 200 ml of anhydrous tetrahydrofuran, 20 ml of anhydrous hexamethylphosphotriamide (EMPT) and 18.7 ml (0.14 mol) of trimethyl phosphite. When the release of hydrogen has finished (about two hours later), the solution is cooled to -10°C and then stirred under an oxygen atmosphere until absorption ceases (duration: 3 hours). Still at -10°C, 136 ml of glacial acetic acid are added, and the mixture is then left at ambient temperature for two hours. After the addition of 500 ml of 1 N sulfuric acid, the aqueous phase is isolated, reextracted with 150 ml of isopropyl ether, made alkaline with 350 ml of 11 N ammonia, then extracted 3 times with 300 ml aliquots of methylene chloride. After drying over calcium chloride and evaporating the solvent, 30.2 g of crude product are obtained which, when chromatographed on a column of silica gel (1.5 kg) yield, 9.9 g of vincamine (yield: 28%) melting point (decomp.): 250°C.
brand name
Cerebroxine;Cetal;Ocu-vinc;Oxygeron;Pervincamine;Vadicate;Vinca minor;Vincacen;Vincapront;Vincavix;Vincimax.
Therapeutic Function
Vasodilator
World Health Organization (WHO)
Vincamine, an alkaloid derived from Vinca minor, is claimed to increase cerebral circulation and utilization of oxygen. It is used in a variety of cerebral disorders and is widely marketed for this purpose.
General Description
Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor L., belonging to the Apocynaceae family.
Vincamine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
View Lastest Price from Vincamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-15 | Vincamine
1617-90-9
|
US $1.00 / mg | 100mg | 0.99 | 5ton/month | ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD | |
 |
2023-11-27 | Vincamine
1617-90-9
|
US $0.00 / kg | 1kg | 99% | 20 tons | Wuhan Senwayer Century Chemical Co.,Ltd | |
 |
2023-08-24 | Vincamine
1617-90-9
|
US $50.00 / kg | 1kg | 99% | 20 tons | Anhui Ruihan Technology Co., Ltd |
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