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Fludarabine phosphate

Fludarabine phosphate
Fludarabine phosphate structure
CAS No.
75607-67-9
Chemical Name:
Fludarabine phosphate
Synonyms
FAMP;Fludura;F-ara-AMP;75607-67-9;2-fluoro-araamp;5-Monophosphate;fludarabine hcl;fludara Phosphate;Fludarabin Phosphate;Fludarbine Phopshate
CBNumber:
CB7347825
Molecular Formula:
C10H13FN5O7P
Formula Weight:
365.21
MOL File:
75607-67-9.mol

Fludarabine phosphate Properties

Melting point:
203°C(dec.)(lit.)
alpha 
[α]D20 +10~+14゜(c=0.5,H2O)
Boiling point:
864.2±75.0 °C(Predicted)
Density 
2.39±0.1 g/cm3(Predicted)
RTECS 
UO7440900
storage temp. 
-20°C
solubility 
DMSO: soluble1mg/mL
pka
1.86±0.10(Predicted)
form 
Powder
color 
white
Water Solubility 
Soluble in DMSO or water at 5mg/ml
Merck 
14,4126
InChIKey
GIUYCYHIANZCFB-GFRUICAKSA-N
CAS DataBase Reference
75607-67-9(CAS DataBase Reference)
FDA UNII
1X9VK9O1SC
NCI Dictionary of Cancer Terms
fludarabine phosphate
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H361-H362-H373-H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P501a-P201-P202-P260-P263-P264-P270-P280-P301+P312+P330-P308+P313-P405-P501
WGK Germany  3
HS Code  2934990002

Fludarabine phosphate price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F9813 Fludarabine phosphate 75607-67-9 5mg $64.4 2021-03-22 Buy
Sigma-Aldrich Y0000419 Fludarabine phosphate European Pharmacopoeia (EP) Reference Standard $190 2021-03-22 Buy
Sigma-Aldrich Y0001536 Fludarabine for system suitability European Pharmacopoeia (EP) Reference Standard $190 2021-03-22 Buy
Sigma-Aldrich 1272204 Fludarabine phosphate 75607-67-9 300mg $366 2021-03-22 Buy
TCI Chemical F0913 Fludarabine Monophosphate >98.0%(HPLC)(T) 75607-67-9 25mg $29 2021-03-22 Buy

Fludarabine phosphate Chemical Properties,Uses,Production

Description

Fludarabine phosphate is an antimetabolite indicated for the treatment of B cell lymphocytic leukemia. It is reportedly effective in patients refractory to other therapies. Fludarabine phosphate acts by inhibiting primer RNA synthesis. Its side effects include bone marrow suppression, anemia, thrombocytopenia and neutropenia.

Chemical Properties

White or almost white, crystalline powder, hygroscopic.

Originator

Southern Research Institute (U.S.A.)

Uses

anticonvulsant

Definition

ChEBI: A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Onc incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.

brand name

Fludara (Berlex).

Pharmacology

Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
Phase I studies in humans have demonstrated that fludarabine phosphate is rapidly converted to the active metabolite, 2-fluoro-ara-A, within minutes after intravenous infusion.
Consequently, clinical pharmacology studies have focused on 2-fluoro-ara-A pharmacokinetics. After the five daily doses of 25 mg 2-fluoro-ara-AMP/m2 to cancer patients infused over 30 minutes, 2-fluoro-ara-A concentrations show a moderate accumulation. During a 5-day treatment schedule, 2-fluoro-ara-A plasma trough levels increased by a factor of about 2. The terminal half-life of 2-fluoro-ara-A was estimated as approximately 20 hours. In vitro, plasma protein binding of fludarabine ranged between 19% and 29%.

Clinical Use

Fludarabine phosphate (Fludara ® ), is a fluorinated nucleotide analog of the antiviral agent vidarabine, 9-β-D-arabinofuranosyladenine(ara-A), which differs only by the presence of a fluorine atom at position 2 of the purine moiety and a phosphate group at position 5 of the arabinose moiety (Plunkett et al., 1993). These structural modifications result in increased aqueous solubility and resistance to enzymatic degradation by adenosine deaminases compared to vidarabine (Brockman et al., 1977; Plunkett et al., 1990). Fludarabine phosphate is indicated for the treatment of patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating agent containing regimen (Boogaerts et al., 2001; Rossi et al., 2004).

Fludarabine phosphate Preparation Products And Raw materials

Raw materials

Preparation Products


Fludarabine phosphate Suppliers

Global( 379)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
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Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19938 60
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View Lastest Price from Fludarabine phosphate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-29 Fludarabine phosphate
75607-67-9
US $0.00-0.00 / Kg 1KG 99.0%+ 800 tons Shaanxi Dideu Medichem Co. Ltd
2019-07-22 Fludarabine Phosphate
75607-67-9
US $1.00 / g 1g 99% 1500 Kilogram/Kilograms per Month Cangzhou Wanyou New Material Technology Co.,Ltd
2018-12-15 Fludarabine phosphate
75607-67-9
US $1.00 / kg 1kg 99% Customized career henan chemical co

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