ChemicalBook >> CAS DataBase List >>10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE

10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE

CAS No.
122955-42-4
Chemical Name:
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
Synonyms
XE 991;XE9912HCl;XE 991 DIHYDROCHLORIDE;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one;9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)-;10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride;10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
CBNumber:
CB7349263
Molecular Formula:
C26H20N2O
Molecular Weight:
376.45
MDL Number:
MFCD05662331
MOL File:
122955-42-4.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Properties

Melting point 231-232 °C
Boiling point 585.0±38.0 °C(Predicted)
Density 1.238±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >20mg/mL
form solid
pka 6.08±0.10(Predicted)
color white to beige
Water Solubility Soluble in water (100mM)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  CB1530000

10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich X2254 XE-991 ≥98% (HPLC) 122955-42-4 10mg $174 2024-03-01 Buy
Sigma-Aldrich X2254 XE-991 ≥98% (HPLC) 122955-42-4 50mg $738 2024-03-01 Buy
Tocris 2000 XE991dihydrochloride ≥99%(HPLC) 122955-42-4 50 $780 2021-12-16 Buy
Tocris 2000 XE991dihydrochloride ≥99%(HPLC) 122955-42-4 10 $187 2021-12-16 Buy
TRC X750953 XE991 122955-42-4 5mg $220 2021-12-16 Buy
Product number Packaging Price Buy
X2254 10mg $174 Buy
X2254 50mg $738 Buy
2000 50 $780 Buy
2000 10 $187 Buy
X750953 5mg $220 Buy

10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Chemical Properties,Uses,Production

Uses

XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).

Biological Activity

Potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks KCNQ2+3/M-currents (IC 50 = 0.6-0.98 μ M) and KCNQ1 homomeric channels (IC 50 = 0.75 μ M) but is less potent against KCNQ1/minK channels (IC 50 = 11.1 μ M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo .

Biochem/physiol Actions

XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).

storage

Room temperature (desiccate)

10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Suppliers

Global( 43)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Ascent Scientific 4401179829988 customerservice@ascentscientific.co.uk United Kingdom 279 60
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 318 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 8944 58
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE XE9912HCl XE 991 XE 991 DIHYDROCHLORIDE 10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride 9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)- 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one 122955-42-4 C26H20N2O2HCl Ion Channels Potassium channel