Prochlorperazine

Prochlorperazine Properties

Melting point	228 °C
Boiling point	260-275 °C(Press: 2 Torr)
Density	1.1679 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Solid
pka	pKa 8.1(H2O,t =24±1,I undefined) (Uncertain)
color	White to Yellow
Water Solubility	14.96mg/L(24 ºC)
BCS Class	2
CAS DataBase Reference	58-38-8(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	prochlorperazine
FDA UNII	YHP6YLT61T
NIST Chemistry Reference	Prochlorperazine(58-38-8)
NCI Drug Dictionary	prochlorperazine
ATC code	N05AB04

Pharmacokinetic data

Protein binding	96%
Excreted unchanged in urine	Minimal
Volume of distribution	23(L/kg)
Biological half-life	6-9 / -

SAFETY

Risk and Safety Statements

Toxicity	LD50 oral in rat: 1800mg/kg

Prochlorperazine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	P755790	Prochlorperazine	58-38-8	10mg	$100	2021-12-16	Buy
Usbiological	462997	Prochlorperazine	58-38-8	10mg	$368	2021-12-16	Buy
ApexBio Technology	A8508	Prochlorperazine	58-38-8	100mg	$21	2021-12-16	Buy
ApexBio Technology	A8508	Prochlorperazine	58-38-8	5g	$45	2021-12-16	Buy
American Custom Chemicals Corporation	API0003935	PROCHLORPERAZINE 95.00%	58-38-8	5MG	$442.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
P755790	10mg	$100	Buy
462997	10mg	$368	Buy
A8508	100mg	$21	Buy
A8508	5g	$45	Buy
API0003935	5MG	$442.5	Buy

Prochlorperazine Chemical Properties,Uses,Production

Uses

antiemetic, antipsychotic, treatment of vertigo

Uses

Prochlorperazine is antiemetic, antipsychotic; used in treatment of vertigo.

Definition

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.

brand name

Compazine (GlaxoSmithKline).

Clinical Use

Nausea and vomiting
Labyrinthine disorders
Psychoses
Severe anxiety

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: headache, blood pressure elevation. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl-.

Veterinary Drugs and Treatments

Prochlorperazine as a single agent is used in dogs and cats as an antiemetic. The only approved products for animals are combination products containing prochlorperazine, isopropamide, with or without neomycin (Darbazine?, Neo-Darbazine?—SKB Labs) which are no longer marketed in the USA. The approved indications for these products include: vomiting, non-specific gastroenteritis, drug induced diarrhea, infectious diarrhea, spastic colitis, and motion sickness in dogs and cats (injectable product only).

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids; increased risk of ventricular arrhythmias with methadone.
Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide, dronedarone and amiodarone - avoid with amiodarone and dronedarone.
Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
Antidepressants: increase concentrations and additive antimuscarinic effects, notably with tricyclics; increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
Antiepileptics: antagonised (convulsive threshold lowered).
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
Desferrioxamine: avoid concomitant use.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias.

Metabolism

Prochlorperazine undergoes extensive first pass metabolism in the gut wall. It is also extensively metabolised in the liver and is excreted in the urine and bile. The metabolites are inactive.

Prochlorperazine Preparation Products And Raw materials

Raw materials

Preparation Products

PERPHENAZINE

Prochlorperazine Suppliers

Global( 96)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9339	58
LUYUNJIA CHEMISTRY XIAMEN LIMITED	+86-592-5360779 +86-13055435203		China	5996	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9116	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58

Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Baoji Guokang Bio-Technology Co., Ltd.	58
LUYUNJIA CHEMISTRY XIAMEN LIMITED	58
Shaanxi Didu New Materials Co. Ltd	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from Prochlorperazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-01-18	prochlorperazine 58-38-8	US $30.00 / kg	1kg	99%	6000	Xiamen Wonderful Bio Technology Co., Ltd.
2021-07-24	Prochlorperazine USP/EP/BP 58-38-8	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited
2021-07-13	Prochlorperazine 58-38-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

prochlorperazine
58-38-8
US $30.00 / kg
99%
Xiamen Wonderful Bio Technology Co., Ltd.

Prochlorperazine USP/EP/BP
58-38-8
US $1.10 / g
99.9%
Dideu Industries Group Limited

Prochlorperazine
58-38-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

58-38-8(Prochlorperazine)Related Search:

2-Chlorophenothiazine Chlorpromazine hydrochloride Allyl chloride 3-Chloropropyltrimethoxysilane Chloromethyl isopropyl carbonate

Chlorpromazine Phenothiazine 3-Methyl-2-butanone Cyclopropyl methyl ketone Xylazine

1-Methylpiperazine PROCHLORPERAZINE DIMALEATE,Prochlorperazine Dimaleate Also See: P755800,PROCHLORPERAZINE MALEATE,PROCHLORPERAZINE DIMALEATE SALT Imiclopazine FLUPHENAZINE Difluorochloromethane

Fluphenazine decanoate PROCHLORPERAZINE MESYLATE Methophenazine

1of4

n-(gamma-(4’-methylpiperazinyl-1’)propyl)-3-chlorophenothiazine N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine n-[gamma-(4’-methylpiperazinyl-1’)propyl]-3-chlorophenothiazine Nipodal Phenothiazine, 2-chloro-10-[3-(1-methyl-4-piperazinyl)propyl]- Chloromeprazine 3-Chloro-10-chlorperazine 10-[3-(4-Methylpiperazino)propyl]-2-chloro-10H-phenothiazine Prochlorperazine Base Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- Prochloroperazine Prochlorpemazine Prochlorperazin prochlorpermazine Prochlorpromazine Procloperazine Proclorperazine rp6140 RP-6140 SKF 4657 skf4657 Stemetil Tementil Temetid PROCHLORPERAZINE 2-chloro-10-(3-(4-methylpiperazin-1-yl)propyl)phenothiazine Bayer A 17 10H-PHENOTHIAZINE, 2-CHLORO-10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-, (Z)-2-BUTENEDIOATE 10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- 2-Chloro-10-(3-(1-methyl-4-piperazinyl)-propyl)-phenothiazine 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10h-phenothiazin 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-phenothiazin 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine 3-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine 6140 R.P. 6140 RP 6140rp Bayer A 173 bayera173 Capazine Chlormeprazine Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine chloro-3(n-methylpiperazinyl-3propyl)-10phenothiazine chloro-3(n-methylpiperazinyl-3propyl)-10phenothiazine(french) Chlorperazine Emelent Eskatrol Kronocin Meterazin Meterazine Prochlorperazine USP/EP/BP Prochlorperazine EP Compazine PERPHENAZINE BASE Praziquantel Impurity 7-d11 58-38-8