4-Chloropyridine-2-carboxylic acid
- CAS No.
- 5470-22-4
- Chemical Name:
- 4-Chloropyridine-2-carboxylic acid
- Synonyms
- 4-CHLOROPICOLINIC ACID;4-chloropicolinic;Chloropicolinicacid;IFLAB-BB F1926-0017;4-ChloropicolinicAci;Sorafenib Impurity 03;4-chloro-2-picolinic acid;4-CHLOROPICOLINIC ACID 99%;4-Chloropicolinic acid ,98%;4-Chloropicolinic acid, 97.5%
- CBNumber:
- CB7353077
- Molecular Formula:
- C6H4ClNO2
- Molecular Weight:
- 157.55
- MDL Number:
- MFCD00191400
- MOL File:
- 5470-22-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Chloro-2-pyridinecarboxylic acid AldrichCPR | CDS000043 | 100MG | $77.9 |
| 4-Chloro-pyridine-2-carboxylic acid Aldrich | ADE000290 | 1g | $230 |
| 4-Chloro-2-pyridinecarboxylic Acid >98.0%(GC)(T) | C1360 | 1g | $64 |
| 4-Chloro-2-pyridinecarboxylic Acid >98.0%(GC)(T) | C1360 | 5g | $208 |
| 4-ChloropicolinicAcid | C370955 | 5g | $195 |
| More product size | |||
| Melting point | 181°C |
|---|---|
| Boiling point | 308.0±22.0 °C(Predicted) |
| Density | 1.470±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 3.27±0.10(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C6H4ClNO2/c7-4-1-2-8-5(3-4)6(9)10/h1-3H,(H,9,10) |
| InChIKey | NNMYRMGMVLMQAY-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)=NC=CC(Cl)=C1 |
| CAS DataBase Reference | 5470-22-4(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Harmful/Irritant/Keep Cold | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Chloropyridine-2-carboxylic acid price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS000043 | 4-Chloro-2-pyridinecarboxylic acid AldrichCPR | 5470-22-4 | 100MG | $77.9 | 2026-03-19 | Buy |
| Sigma-Aldrich | ADE000290 | 4-Chloro-pyridine-2-carboxylic acid Aldrich | 5470-22-4 | 1g | $230 | 2026-03-19 | Buy |
| TCI Chemical | C1360 | 4-Chloro-2-pyridinecarboxylic Acid >98.0%(GC)(T) | 5470-22-4 | 1g | $64 | 2026-03-19 | Buy |
| TCI Chemical | C1360 | 4-Chloro-2-pyridinecarboxylic Acid >98.0%(GC)(T) | 5470-22-4 | 5g | $208 | 2026-03-19 | Buy |
| TRC | C370955 | 4-ChloropicolinicAcid | 5470-22-4 | 5g | $195 | 2021-12-16 | Buy |
4-Chloropyridine-2-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
4-Chloropicolinic Acid is a reactant used in the synthesis of VU0431316, a negative allosteric modulator of mGlu5.
Synthesis
98-98-6
5470-22-4
General procedure for the synthesis of 4-chloropyridine-2-carboxylic acid from 2-pyridinecarboxylic acid: a suspension of 2-pyridinecarboxylic acid (0.79 g, 6.35 mmol) and sodium bromide (1.30 g, 12.7 mmol) in 10 mL of thionyl chloride was heated for 20 hr under mild reflux conditions. During the reaction, the initial dark green color of the mixture gradually changed to a deep red color. Upon completion of the reaction, the excess thionyl chloride was removed by rotary evaporation, and the resulting orange residue was dissolved in about 15 mL of dichloromethane and filtered through diatomaceous earth to remove insoluble impurities. The orange filtrate was cooled to -2°C and 20 mL of double-distilled water was slowly added under vigorous stirring while maintaining the reaction temperature between -2 and 2°C. At this point, the color of the solution changed to light orange and a white precipitate was produced. Subsequently, the mixture was continued to be stirred at room temperature for 20 hours. Afterwards, dichloromethane and water were removed by rotary evaporation. Finally, the solid product was recrystallized from a minimal amount of ethanol to give 0.28 g (28% yield) of 4-chloropyridine-2-carboxylic acid. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ= 8.72 (1H, d, J = 4.9 Hz), 8.09 (1H, d, J = 1.6 Hz), 7.84 (1H, dd, J = 4.9, 1.6 Hz).
References
[1] Patent: WO2008/17855, 2008, A1. Location in patent: Page/Page column 48-49
[2] Synthetic Communications, 1996, vol. 26, # 10, p. 2017 - 2025
[3] Patent: US2006/160803, 2006, A1. Location in patent: Page/Page column 136
[4] Patent: EP1650194, 2006, A1. Location in patent: Page/Page column 37
4-Chloropyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13815 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
View Lastest Price from 4-Chloropyridine-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 4-Chloropyridine-2-carboxylic acid
5470-22-4
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-04-04 | 4-Chloropyridine-2-carboxylic acid
5470-22-4
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-07-02 | 4-Chloropyridine-2-carboxylic acid
5470-22-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 4-Chloropyridine-2-carboxylic acid
5470-22-4
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 4-Chloropyridine-2-carboxylic acid
5470-22-4
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-Chloropyridine-2-carboxylic acid
5470-22-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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