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Oxymetholone

Mechanism of Action Indication Dosage Contraindications Side Effects Warnings
Oxymetholone
Oxymetholone structure
CAS No.
434-07-1
Chemical Name:
Oxymetholone
Synonyms
ci406;Adroyd;CI-406;C07393;Anadrol;Becorel;Raboral;Roboral;Adroidin;Anadroyd
CBNumber:
CB7353507
Molecular Formula:
C21H32O3
Formula Weight:
332.48
MOL File:
434-07-1.mol

Oxymetholone Properties

Melting point:
172-180°C
alpha 
34 º
Boiling point:
409.59°C (rough estimate)
Density 
1.0834 (rough estimate)
refractive index 
38 ° (C=1, CHCl3)
storage temp. 
2-8°C
solubility 
H2O: ≤0.5 mg/mL
form 
solid
color 
white to light yellow
Water Solubility 
<0.1 g/100 mL at 23 ºC
Merck 
6967
Stability:
Stability May be light sensitive. Combustible. Incompatible with strong oxidizing agents.
InChIKey
ICMWWNHDUZJFDW-CCTJMHFWSA-N
CAS DataBase Reference
434-07-1(CAS DataBase Reference)
NIST Chemistry Reference
Oxymetholone(434-07-1)
EPA Substance Registry System
Androstan-3-one, 17-hydroxy-2-(hydroxymethylene)- 17-methyl-, (5.alpha.,17.beta.)-(434-07-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H351-H361
Precautionary statements  P280-P281
Hazard Codes  T,Xn
Risk Statements  40-63
Safety Statements  53-22-26-36/37/39-36
WGK Germany  3
RTECS  BV8060000
HS Code  29372900

Oxymetholone price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1487007 Oxymetholone United States Pharmacopeia (USP) Reference Standard 434-07-1 200mg $448.35 2018-11-20 Buy
Sigma-Aldrich O0380 Oxymetholone analytical standard 434-07-1 5g $466 2018-11-20 Buy
Cayman Chemical 21643 Oxymetholone ≥98% 434-07-1 1mg $29 2018-11-19 Buy
Cayman Chemical 21643 Oxymetholone ≥98% 434-07-1 5mg $131 2018-11-19 Buy

Oxymetholone Chemical Properties,Uses,Production

Mechanism of Action

The influence of testosterone in humans takes on two main pathways: generation of the androgen receptor as 5α-dihydrotestosterone (DHT) or directly, and by transformation into estradiol and generation of specific estrogen receptors. Unrestrained receptors are transferred into the cytoplasm of the selected tissue cells where it bonds with the androgen receptors, or it is reduced to DHT by 5α-reductase. The binding points are referred to as hormone response elements, and they determine the transcriptional activity of specific genes, which result in the androgenic effects.

Indication

Oxymetholone is indicated for the treatment of anemias that are resultant of ineffective red cell production, such as myelofibrosis, acquired aplastic anemia, congenital aplastic anemia and hypoplastic anemia. The drug should not be prescribed as a replacement for other supplementary measures such as antibacterial therapy, pyridoxine deficiency or vitamin B12, folic acid, rectification of iron, transfusion and the correct use of corticosteroids.

Dosage

The recommended dose of Oxymetholone is 1-5mg/kg administered daily based on the patient’s body weight. The most effective dose is 1-2mg/kg per day, but a patient may necessitate higher doses, which can be individualized.
Response to Oxymetholone is not immediate hence a minimum trial period of 3-6months should be indicated. In instances of remission, some patients thrive without the medication whereas an established dosage can support some with lower dose indications. For patients with congenital aplastic anemia, a regular maintenance dose should be prescribed.

Contraindications

Oxymetholone should not be prescribed for patients with severe kidney or liver disease, female breast cancer with the affirmation of high calcium levels in the blood, male breast cancer, prostate cancer, and if one is pregnant.
Oxymetholone is also contraindicated in patients who have coronary artery disease, diabetes, blood clotting or bleeding disorder, enlarged prostate, high levels of triglycerides or cholesterol, cognitive heart failure or if they are taking blood thinners such as Jantoven, Coumadin and Warfarin. The drug is also contraindicated in patients who are hypersensitive to Oxymetholone, patients with nephrosis and those with adverse hepatic dysfunction.

Side Effects

Common side effects associated with Oxymetholone use in men and women include diarrhea, vomiting, nausea, insomnia, feeling excited or restless, increased or reduced libido, breast tenderness/swelling, male pattern baldness and acne.
In men, Oxymetholone may result in bladder irritability, a reduction in original volume, epididymitis, chronic priapism, impotence, testicular oligospermia and atrophy, and suppression of testicular function.
Prolonged Oxymetholone use can result in blood-filled cysts or tumors in the spleen or the liver. One may need to consult a doctor if they experience painful urination, loss of appetite, jaundice, dark urine, fast weight gain in the midsection or the face, clay-colored stools, pain on the upper section of the stomach and nausea.

Warnings

Oxymetholone should not be prescribed for patients who are allergic to the drug. This drug should not be prescribed for patients who are under 18 years unless it is under strict supervision by a doctor, where the doctor will also take x-rays of the patient every 6 months to ascertain that Oxymetholone is not affecting the child’s bone development.

Description

Oxymetholone is a synthetic, orally active anabolic-androgenic steroid (AAS) and 17α-methylated derivative of dihydrotestosterone (DHT). It is mainly used for the treatment of osteroporosis and anemia (low red blood cell count). It can also stimulate the muscle growth in malnourished or underdeveloped patients. It also has the potential to treat the HIV wasting syndrome. Oxymetholone can also lead to an even buildup in strength, which is its secondary characteristics, making it an excellent steroid to be coupled with other anabolic steroids to yield synergetic effect.

Chemical Properties

Oxymetholone is a white to pale yellow crystalline solid or powder. Odorless.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Anabolic steroid. Controlled substance

Definition

ChEBI: A 3-oxo-steroid that is 4,5alpha-dihydrotestosterone which is substituted by a hydroxymethylidene group at position 2 and by a methyl group at the 17alpha position. A synthetic androgen, it was mainly used for the treatmen of anaemias until being replaced by treatments with fewer side effects.

brand name

Anadrol (Alaven).

General Description

Odorless white to creamy white crystalline powder.

General Description

Oxymetholone, 17β-hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one, is approvedfor the treatment of various anemias.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Oxymetholone may be sensitive to light.

Health Hazard

SYMPTOMS: Symptoms of exposure to Oxymetholone may include cholestatic jaundice, hepatocellular neoplasms and peliosis hepatitis. Prepubertal exposure may cause phallic enlargement and increased frequency of erection. Postpubertal exposure may cause inhibition of testicular function, testicular atrophy, oligospermia, impotence, chronic priapism, epididymitis, bladder irritability, clitoral enlargement, menstrual irregularities, increased or decreased libido, excitation, insomnia, nausea, vomiting, diarrhea, leukemia, gynecomastia, deepening of the voice in women, hirsutism and male-pattern baldness in women, acne, edema, retention of serum electrolytes and decreased glucose tolerance. It may also cause higher risk of developing liver cell tumors. Other symptoms include abnormal liver function tests, salt and water retention and masculinization, particularly of the female fetus.

Fire Hazard

Flash point data for Oxymetholone are not available. Oxymetholone is probably combustible.

Safety Profile

Confirmed human carcinogen producing liver tumors. Human systemic effects by ingestion: impaired liver function. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also TESTOSTERONE.

Potential Exposure

Oxymetholone is a controlled substance (US), hormone and a systemic anabolic steroid.

Carcinogenicity

Oxymetholone is reasonably anticipated to be a human carcinogenbased on limited evidence of carcinogenicity in humans.

Shipping

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides. May be combustible and light-sensitive.

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, doublebagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Regulations

Consumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Food and Drug Administration (FDA)
Oxymetholone is a prescription drug subject to labeling and other requirements.

Oxymetholone Preparation Products And Raw materials

Raw materials

Preparation Products


Oxymetholone Suppliers

Global( 174)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com CHINA 690 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21696 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 272 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
Hebei Minshang Biotechnology Co., Ltd
+86-13582176207
cathy@hbminshang.com CHINA 272 58

View Lastest Price from Oxymetholone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-09-08 Oxymetholone
434-07-1
US $1.00 / g 1g 99.8% 1 GZ HONCH CHEMICAL TECHNOLOGY CO.,LTD
2019-07-05 Oxymetholone
434-07-1
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-07-31 Anadrol
434-07-1
US $1.00 / g 1g 99% 1000000 kg Cangzhou Wanyou New Material Technology Co.,Ltd

Oxymetholone Spectrum


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