2-Methoxy-5-sulfamoylbenzoic acid
- CAS No.
- 22117-85-7
- Chemical Name:
- 2-Methoxy-5-sulfamoylbenzoic acid
- Synonyms
- Sulpride Impurity D;Sulpiride IMpurity D;Sulpiride EP Impurity D;Sulpiride Impurity D(EP);5-SulfaMoyl-o-anisic Acid;5-sulphamoyl-o-anisic acid;Levosulpiride - EP Impurity D;2-Methoxy-5-sulfamoylbenzoicaci;2-METHOXY-5-SULFONYLBENZOIC ACID;2-METHOXY-5-SULFAMOYLBENZOIC ACID
- CBNumber:
- CB7354418
- Molecular Formula:
- C8H9NO5S
- Molecular Weight:
- 231.23
- MDL Number:
- MFCD00129997
- MOL File:
- 22117-85-7.mol
| Melting point | 220 °C |
|---|---|
| Boiling point | 482.5±55.0 °C(Predicted) |
| Density | 1.492±0.06 g/cm3(Predicted) |
| storage temp. | Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.56±0.10(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 22117-85-7(CAS DataBase Reference) |
| FDA UNII | ZK66UU128U |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2922500090 | |||||||||
| NFPA 704 |
|
2-Methoxy-5-sulfamoylbenzoic acid price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | B23698 | 2-Methoxy-5-sulfamoylbenzoic acid, 97% | 22117-85-7 | 10g | $45.65 | 2024-03-01 | Buy |
| Alfa Aesar | B23698 | 2-Methoxy-5-sulfamoylbenzoic acid, 97% | 22117-85-7 | 50g | $129.65 | 2024-03-01 | Buy |
| Alfa Aesar | B23698 | 2-Methoxy-5-sulfamoylbenzoic acid, 97% | 22117-85-7 | 250g | $459 | 2021-12-16 | Buy |
| TRC | M326640 | 2-Methoxy-5-sulfamoylbenzoicAcid | 22117-85-7 | 10g | $180 | 2021-12-16 | Buy |
| Apolloscientific | OR3567 | 2-Methoxy-5-sulphamoylbenzoicacid | 22117-85-7 | 250g | $215 | 2021-12-16 | Buy |
2-Methoxy-5-sulfamoylbenzoic acid Chemical Properties,Uses,Production
Uses
2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride (S689145).
Preparation
Synthesis of 2-methoxy-5-sulfamoyl benzoic Acid: In the amination reaction of 2-methoxyl-5-amino-sulfonyl benzoic acid, the main influence factors were mainly ammonia concentration, reaction temperature and reaction time. Firstly, we investigated two approaches of animation reaction: ventilation with ammonia in solvent and ammonium hydroxide as amino-reactant and solvent. In this section, the way of ventilation with ammonia in methyl alcohol and tetrahydrofuran would cause the rapid reaction, resulting to the incomplete reaction of 2-methoxy-5-sulfamoylbenzoic acid owing to the formation of 2-methoxy-5-sulfamoyl benzoic acid coated on the surface of the reaction. On the contrary, the lab test indicated that the way of ammonium hydroxide as amino-reactant and solvent can provide better experimental results. Secondly, the reactive temperature was the more important factor. The optimized amination temperature was to 30 °C. The low temperature would result to the long amination time, whereas high temperature can result to the generation of by-product owing to the hydrolysis of sulfonyl chloride. Finally, we evaluated the effect of reaction time. The optimized reaction time was to 5 hours. The extended reaction time can’t cause the significant improvement of yield. As a consequence, the best reactive temperature was to 30 °C and the best mole ratio between 2-methoxy-5-sulfonylchlorobenzoic acid and ammonium hydroxide was to 1:20 and the best reactive time was to 5 hours. Under the best conditions, the yield can reach to 75.8%.
2-Methoxy-5-sulfamoylbenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Chemsigma International Co., Ltd. | +86-18136843612 +86-19951791336 | info@chemsigma.com | China | 963 | 58 |
View Lastest Price from 2-Methoxy-5-sulfamoylbenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2-Methoxy-5-sulfamoylbenzoic acid
22117-85-7
|
US $7.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
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- 2-Methoxy-5-sulfamoylbenzoic acid
22117-85-7
- US $7.00 / kg
- 99%
- Career Henan Chemical Co