DIPHENYLENEIODONIUM CHLORIDE
- CAS No.
- 4673-26-1
- Chemical Name:
- DIPHENYLENEIODONIUM CHLORIDE
- Synonyms
- DPI;DPI CHLORIDE;ibenziodoliumchloride;DIBENZIODOLIUM CHLORIDE;Dibenz[b,d]iodoliuM Chloride;DIPHENYLENEIODONIUM CHLORIDE;Diphenyl iodine chloride salt;Dibenziodolium chloride, DPI;Diphenyleneiodoniumchloride(DPI);dibenzo[b,d]iodol-5-ium chloride
- CBNumber:
- CB7355273
- Molecular Formula:
- C12H8ClI
- Molecular Weight:
- 314.55
- MDL Number:
- MFCD00214165
- MOL File:
- 4673-26-1.mol
- MSDS File:
- SDS
| Melting point | 312-322 °C |
|---|---|
| storage temp. | room temp |
| solubility | Soluble in DMSO (up to 5 mg/ml with warming) |
| form | Powder |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| FDA UNII | 7M9D81YZ2N |
DIPHENYLENEIODONIUM CHLORIDE price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D2926 | Diphenyleneiodonium chloride ≥98% | 4673-26-1 | 10mg | $115 | 2024-03-01 | Buy |
| Sigma-Aldrich | D2926 | Diphenyleneiodonium chloride ≥98% | 4673-26-1 | 50mg | $280.2 | 2024-03-01 | Buy |
| Alfa Aesar | J64838 | Diphenyleneiodonium chloride | 4673-26-1 | 50mg | $298 | 2024-03-01 | Buy |
| Alfa Aesar | J64838 | Diphenyleneiodonium chloride | 4673-26-1 | 100mg | $478.65 | 2024-03-01 | Buy |
| Cayman Chemical | 81050 | Diphenyleneiodonium (chloride) ≥99% | 4673-26-1 | 5mg | $44 | 2024-03-01 | Buy |
DIPHENYLENEIODONIUM CHLORIDE Chemical Properties,Uses,Production
Description
Diphenyleneiodonium (DPI) is an inhibitor of NADPH oxidase (NOX; EC50 = 0.1 μM in HeLa cells). It also inhibits nitric oxide synthase (NOS; IC50 = 0.05 μM in isolated mouse peritoneal macrophages). DPI (10, 50, and 100 μM) induces the production of reactive oxygen species (ROS) in, and apoptosis of, human umbilical vein endothelial cells (HUVECs). It inhibits NETosis induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils when used at a concentration of 10 μM. DPI (2 mg/kg) reduces tumor growth in HT-29 and LS 174T colon cancer mouse xenograft models.
Chemical Properties
Crystalline Solid
Uses
Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase.Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90
Uses
Binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase. Solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90
Uses
Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase. Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90
Definition
ChEBI: An organic chloride salt having dibenziodolium as the counterion.
Biochem/physiol Actions
A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.
storage
Desiccate at -20°C
References
1) Stuehr?et al.?(1991),?Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs; FASEB J.,?5?98 2) Yea?et al.?(1990),?Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase; Biochem. J.,?265?95 3) Ye?et al.?(2014),?Identification of a novel small-molecule agonist for human G protein-coupled receptor 3; J. Pharmacol. Exp. Ther.,?349?4371 4) Mendes?et al.?(2001),?Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species; Mediators Inflamm.,?10?209 5) Kono?et al.?(2001),?Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat;?Am. J. Physiol. Gastrointest. Liver Physiol.,?280?G1005
DIPHENYLENEIODONIUM CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from DIPHENYLENEIODONIUM CHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-28 | DIPHENYLENEIODONIUM CHLORIDE
4673-26-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-23 | DIPHENYLENEIODONIUM CHLORIDE
4673-26-1
|
US $40.00-40.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2019-12-25 | DIPHENYLENEIODONIUM CHLORIDE
4673-26-1
|
US $1.00 / KG | 1KG | 99% | G/KG/T | Career Henan Chemical Co |
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- DIPHENYLENEIODONIUM CHLORIDE
4673-26-1
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- DIPHENYLENEIODONIUM CHLORIDE
4673-26-1
- US $40.00-40.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- DIPHENYLENEIODONIUM CHLORIDE
4673-26-1
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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