Promazine hydrochloride

Promazine hydrochloride Properties

Melting point	174-176?C
Density	1.1435 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
color	White
BRN	3753230
CAS DataBase Reference	53-60-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	U16EOR79U4
NIST Chemistry Reference	N,N-dimethyl-10H-phenothiazine-1-propanamine hydrochloride(53-60-1)
EPA Substance Registry System	Promazine hydrochloride (53-60-1)

Pharmacokinetic data

Protein binding	95-98%
Excreted unchanged in urine	<1%
Volume of distribution	7-20(L/kg)
Biological half-life	23-37 / Unchanged Pharmacokinetic data as for chlorpromazine

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H317
Precautionary statements	P280-P301+P312+P330
Hazard Codes	Xn
Risk Statements	22-43
Safety Statements	36
WGK Germany	3
RTECS	SO8575000
HS Code	2934302300

Promazine hydrochloride price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR3228	Promazine Hydrochloride pharmaceutical secondary standard, certified reference material	53-60-1	500MG	$230	2024-03-01	Buy
Sigma-Aldrich	46674	Promazine hydrochloride VETRANAL , analytical standard	53-60-1	250mg	$73.4	2024-03-01	Buy
Sigma-Aldrich	1569000	Promazine hydrochloride United States Pharmacopeia (USP) Reference Standard	53-60-1	200mg	$436	2024-03-01	Buy
Sigma-Aldrich	P6656	Promazine hydrochloride	53-60-1	25g	$112	2024-03-01	Buy
Sigma-Aldrich	P3390000	Promazine hydrochloride European Pharmacopoeia (EP) Reference Standard	53-60-1	p3390000	$150	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHR3228	500MG	$230	Buy
46674	250mg	$73.4	Buy
1569000	200mg	$436	Buy
P6656	25g	$112	Buy
P3390000	p3390000	$150	Buy

Promazine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Promazine hydrochloride has been used in conductivity and surface tension measurements and for testing inhibition of feline coronavirus (FCoV) in Felis catus whole fetus-4 (fcwf-4) cells.

Uses

Antipsychotic. Tranquilizer.

Definition

Isomeric with promethazine hydrochloride.

brand name

Sparine (Baxter Healthcare); Sparine (Wyeth).

General Description

Promazine hydrochloride (PMZ) belongs to the phenothiazine drug family. Promazine is a D2 dopamine receptor antagonist and has antipsychotic and anticholinergic functionality. It is used for pain management and is also used for treating hypersensitivity reactions.

Biochem/physiol Actions

D2 dopamine receptor antagonist; phenothiazine antipsychotic.

Clinical Use

Antipsychotic for agitation and restlessness

Safety Profile

Poison by ingestion, subcutaneous, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: general anesthesia, tremors, antipsychotic effects. An addltive permitted in food for human consumption; also permitted in the feed and drinhng water of animals and/or for the treatment of food-producing animals. When heated to decomposition it emits toxic fumes of NOx, SOx, and HCl

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids; increased risk of ventricular arrhythmias with methadone.
Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide, dronedarone and amiodarone - avoid with amiodarone and dronedarone.
Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
Antidepressants: increase concentrations and additive antimuscarinic effects, notably with tricyclics; increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
Antiepileptics: antagonised (convulsive threshold lowered).
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
Desferrioxamine: avoid concomitant use.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias.
Anti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval - avoid with amiodarone, disopyramide and dronedarone.
Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
Antidepressants: increased level of tricyclics (possibly increased risk of ventricular arrhythmias and antimuscarinic side effects); increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
Anticonvulsant: antagonises anticonvulsant effect.
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias.

Metabolism

Promazine undergoes considerable first-pass metabolism in the gut wall. It is also extensively metabolised in the liver and is excreted in the urine and faeces in the form of numerous active and inactive metabolites.

Promazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Promazine hydrochloride Suppliers

Global( 116)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hebei Lingding Biotechnology Co., Ltd.	+86-18031140164 +86-19933155420	erin@hbldbiotech.com	China	878	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Hebei Lingding Biotechnology Co., Ltd.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from Promazine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-01-18	Promazine hydrochloride 53-60-1	US $30.00 / kg	1kg	99.98%	8000	Xiamen Wonderful Bio Technology Co., Ltd.
2023-02-03	Promazine hydrochloride 53-60-1	US $0.00 / G	1G	98%min	30kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2022-01-15	Promazine hydrochloride 53-60-1	US $75.00-62.00 / KG	1KG	99%	9000kg/per week	Hebei Lingding Biotechnology Co., Ltd.

Promazine hydrochloride
53-60-1
US $30.00 / kg
99.98%
Xiamen Wonderful Bio Technology Co., Ltd.

Promazine hydrochloride
53-60-1
US $0.00 / G
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Promazine hydrochloride
53-60-1
US $75.00-62.00 / KG
99%
Hebei Lingding Biotechnology Co., Ltd.

53-60-1(Promazine hydrochloride)Related Search:

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