Sincalide | 25126-32-3

Sincalide Properties

Melting point	>193°C (dec.)
alpha	D23 -18.4° (c = 0.7 in 1N NH3)
Density	1.440±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	0.05 M ammonium hydroxide: 1 mg/mL, clear, colorless
form	powder
pka	-4.17±0.18(Predicted)
color	Off-White
Water Solubility	Soluble in water 1 g/L at 10°C.
Merck	13,8617
BRN	5231801
Sequence	H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
InChIKey	IZTQOLKUZKXIRV-IVVJSLGPSA-N
FDA UNII	M03GIQ7Z6P
ATC code	V04CC03

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P260-P271-P280
Safety Statements	22-24/25
WGK Germany	3
F	8-10-21
HS Code	2933998090

Sincalide price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C2175	(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide ≥97% (HPLC), powder	25126-32-3	250μg	$240	2024-03-01	Buy
Sigma-Aldrich	C2175	(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide ≥97% (HPLC), powder	25126-32-3	0.5mg	$415	2024-03-01	Buy
Sigma-Aldrich	C2175	(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide ≥97% (HPLC), powder	25126-32-3	1mg	$566	2024-03-01	Buy
Alfa Aesar	J66669	Cholecystokinin, CCK Octapeptide (26-33)	25126-32-3	0.5mg	$102	2023-06-20	Buy
Alfa Aesar	J66669	Cholecystokinin, CCK Octapeptide (26-33)	25126-32-3	1mg	$156	2023-06-20	Buy

Product number	Packaging	Price	Buy
C2175	250μg	$240	Buy
C2175	0.5mg	$415	Buy
C2175	1mg	$566	Buy
J66669	0.5mg	$102	Buy
J66669	1mg	$156	Buy

Sincalide Chemical Properties,Uses,Production

Originator

Kinevac,Squibb,US,1976

Uses

Choleretic.

Uses

Sincalide is used in the biological studies in the preparation of opioid receptors agonistic and CCK receptor antagonistic activity.

Definition

ChEBI: Sincalide is an oligopeptide.

Manufacturing Process

The starting material in the following synthesis is: t-butyloxycarbonyl-Laspartyl- L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-aspartyl-Lphenylalanine amide designated (SM)
.(A) A solution of (SM) (320 mg) in trifluoroacetic acid (7 ml) was kept under nitrogen at room temperature for 15 minutes. Ether (100 ml) was added and the precipitate filtered, washed thoroughly with ether and dried. This material (280 mg) was added to concentrated sulfuric acid (20 ml), cooled at -20°C. The solution was kept in the dry ice-acetone bath at -20°C for 75 minutes. The sulfuric acid solution was poured into ice water (80 ml). The precipitate was centrifuged, resuspended in ice water (30 ml) and 4N sodium hydroxide was added until a clear solution was obtained. After reacidification to pH 4 with dilute sulfuric acid, the precipitate formed was centrifuged, washed twice with ice water and dried. Yield 155 mg. Chromatograph of DEAE Sephadex (with ammonium carbonate buffer) yielded the desired octapeptide sulfate ester: 30 mg.
(B) A solution of (SM) (330 mg) in trifluoroacetic acid (7 ml) was kept under nitrogen at room temperature for 15 minutes. Ether (100 ml) was added and the precipitate was filtered, washed thoroughly with ether and dried. This material (300 mg) was added in portions to concentrated sulfuric acid (18 ml) cooled at -20°C with vigorous stirring. After 15 minutes a solution of potassium bisulfate in concentrated sulfuric acid (408 mg in 3 ml) was added. The reaction mixture was stirred for 75 minutes at -15°C and then stored at - 7°C for 285 minutes. The sulfuric acid solution was poured into cold ether (400 ml); precipitate was filtered, washed with cold ether, and suspended in cold water. Complete solution was then achieved by careful addition of 2N sodium hydroxide. Acidification with N hydrochloric acid led to the precipitation of the desired octapeptide sulfate ester. Yield 200 mg.

brand name

Kinevac (Bracco).

Therapeutic Function

Choleretic

General Description

It was thought originally that cholecystokinin and pancreozyminwere two different hormones. Cholecystokinin wasthought to be responsible for contraction of the gallbladder,whereas pancreozymin was believed to induce secretion ofpancreatic enzymes. It is now clear that both actions arecaused by a single 33-residue polypeptide, referred to ascholecystokinin–pancreozymin (CCK-PZ). CCK-PZ is secretedin the blood in response to the presence of food in theduodenum, especially long-chain fatty acids. The fiveCOOH-terminal amino acid residues are identical with thosein gastrin. The COOH-terminal octapeptide retains full activityof the parent hormone.

Biochem/physiol Actions

Neurotransmitter; predominant form of CCK in CNS and gastrointestinal tract; may play a role in satiety.

storage

Store at -20°C

Sincalide Preparation Products And Raw materials

Raw materials

Sulfuric acid

Preparation Products

Sincalide Suppliers

Global( 254)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	999	58

Supplier	Advantage
GIHI CHEMICALS CO.,LIMITED	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Cellmano Biotech Limited	58

View Lastest Price from Sincalide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-08	Cholecystokinin Octapeptide (sulfated) ammonium salt 25126-32-3	US $10.00 / kg	1kg	99%	1000kg	Nantong Guangyuan Chemicl Co,Ltd
2024-01-02	Sincalide 25126-32-3	US $70.00-700.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2023-11-27	Sincalide 25126-32-3	US $0.00 / GRAM	1GRAM	99%	20 TONS	Wuhan Senwayer Century Chemical Co.,Ltd

Cholecystokinin Octapeptide (sulfated) ammonium salt
25126-32-3
US $10.00 / kg
99%
Nantong Guangyuan Chemicl Co,Ltd

Sincalide
25126-32-3
US $70.00-700.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

Sincalide
25126-32-3
US $0.00 / GRAM
99%
Wuhan Senwayer Century Chemical Co.,Ltd

25126-32-3(Sincalide)Related Search:

sinapultide Oxytocin VAPREOTIDE Abaloparatide Ganirelix Acetate

Etelcalcetide Thyrotropin-releasing hormone PASIREOTIDE Cholecystokinin desulfated sincalide

(TYR9)-CHOLECYSTOKININ OCTAPEPTIDE (SULFATED) Sincalide sincalide, pGlu- sincalide, Phe(CH2SO3Na)(2)- L-ILE-SER-ASP-ARG-ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2

BOC CCK-8 ([125I]-TYR)-CHOLECYSTOKININ OCTAPEPTIDE (DESULFATED) (OBUT1)-CHOLECYSTOKININ 26-33 PROTECTED

1of4

CHOLECYSTOKININ, OCTAPEPTIDE (26-33), SULFATED CHOLECYSTOKININ OCTAPEPTIDE (SULFATED) CHOLECYSTOKININ OCTAPEPTIDE (SULFATED) AMMONIUM SALT CHOLECYSTOKININ-8 (26-33), HUMAN, SULPHATED AMIDE CHOLECYSTOKININ FRAGMENT 26-33 SULFATED CHOLECYSTOKININ (26-33), SULFATED CHOLECYSTOKININ (26-33) (SULFATED) AMMONIUM SALT CCK OCTAPEPTIDE SULFATED CCK, OCTAPEPTIDE (26-33), SULFATED CCK-OCTAPEPTIDE (26-33) (SULFATED) AMMONIUM CCK-OCTAPEPTIDE(26-33)(SULFATED FORM) CCK OCTAPEPTIDE (CCK-8), SULFATED CCK 26-33, SULFATED CCK-8, SULFATED CCK-8 (SULFATED) AMMONIUM CCK-8 (SULFATED) AMMONIUM SALT CCK-8 (26-33), HUMAN, SULPHATED AMIDE D-Y(SO3H)-MGWMDF-NH2 ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2 ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2 AMMONIUM SINCALIDE (CCK-8) Sincalide ammonium salt Cholecystokinin Octapeptide (sulfated),Sincalide Sincalid Cholecystokinin C-terminal octapeptide Cholecystokinin-pancreozymin SQ-19844 CCK-8, Cholecystokinin octapeptide, Pancreozymin C-terminal octapeptide, Sincalide Cholecystokinin, CCK Octapeptide (26-33) Cholecystokinin Octapeptide, sulfated, CCK-8S Sincalide H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 Cholecystokinin (26-33), CCK Octapeptide, sulfated Cholecystokinin Octapeptide (sulfated) Sincalide, CCK-8 (sulfated), Cholecystokinin (26-33) (sulfated) Sincalide, CCK-8 (sulfated), Cholecystokinin (26-33) (sulfated) Sincalide (Kinevac) [27-TYR(SO3H)]CHOLECYSTOKININ-FRAGMENT (26-33)-AMIDE PANCREOZYMIN C-TERMINAL OCTAPEPTIDE SINCALIDE Sincalid(CCK-8) (tyr(so3H)27)-cholecystokinin fragment*26-33 amid H-ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2 H-ASP-TYR(SO3H)-MET-GLY-TRP-MET-ASP-PHE-NH2 AMMONIUM SALT CHOLECYSTOKININ [TYR(SO3H)27]-FRAGMENT 26-33 AMIDE CCK Octapeptide CCK-8;SQ-19844;CCK OCTAPEPTIDE (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-(methylthio)-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl SINCALIDE, >99% Sincalide,CCK-8,SQ19844,Cholecystokinin octapeptide, >99% 3-10-Caerulein, 5-L-methionine- Sincalide?Acetate impurity Sincalide USP/EP/BP Sincalide，CCK-8，SQ19844，Cholecystokinin octapeptide Sincalide 25126-32-3 CCK-8 Cholecystokinin octapeptide Sincalide Acetate (Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide Sinkalite