Flavopiridol
- CAS No.
- 146426-40-6
- Chemical Name:
- Flavopiridol
- Synonyms
- Alvocidib;CS-180;C077990;L86-8275;L-868275;L 868275;Hmr 1275;FLAVOPIRIDOL;Flavopirodol;HMR-1275; L86-8275
- CBNumber:
- CB7362013
- Molecular Formula:
- C21H20ClNO5
- Molecular Weight:
- 401.84
- MDL Number:
- MFCD20501884
- MOL File:
- 146426-40-6.mol
- MSDS File:
- SDS
| Melting point | 52.5 °C |
|---|---|
| Boiling point | 603.6±55.0 °C(Predicted) |
| Density | 1.448±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic |
| form | Yellow powder. |
| pka | 6.16±0.40(Predicted) |
| InChIKey | BIIVYFLTOXDAOV-YVEFUNNKSA-N |
| SMILES | C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1 |
| CAS DataBase Reference | 146426-40-6(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | alvocidib; flavopiridol; HMR 1275 |
| FDA UNII | 45AD6X575G |
| NCI Drug Dictionary | alvocidib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
Flavopiridol price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26024 | Flavopiridol ≥95% | 146426-40-6 | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 26024 | Flavopiridol ≥95% | 146426-40-6 | 25mg | $208 | 2024-03-01 | Buy |
| Cayman Chemical | 26024 | Flavopiridol ≥95% | 146426-40-6 | 50mg | $384 | 2024-03-01 | Buy |
| Cayman Chemical | 26024 | Flavopiridol ≥95% | 146426-40-6 | 100mg | $656 | 2024-03-01 | Buy |
| Biorbyt Ltd | orb154639 | Flavopiridol >99% | 146426-40-6 | 100mg | $690.2 | 2021-12-16 | Buy |
Flavopiridol Chemical Properties,Uses,Production
Uses
Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.
Uses
Antineoplastic (cyclin-dependent kinase inhibitor)[Note—The trivial name, flavopiridol, has appeared in literature].
Definition
ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+).
Anticancer Research
It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).
Flavopiridol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
View Lastest Price from Flavopiridol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | Flavopiridol
146426-40-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-10 | Flavopiridol
146426-40-6
|
US $3.00 / KG | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- Flavopiridol
146426-40-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Flavopiridol
146426-40-6
- US $3.00 / KG
- 98%
- Career Henan Chemical Co