EMBELIN
- CAS No.
- 550-24-3
- Chemical Name:
- EMBELIN
- Synonyms
- EMBELIN;emberine;NSC 91874;embelicacid;Embelin, >98%;XIAP INHIBITOR;EMbeliaquinone;TIMTEC-BB SBB005949;Embelin (Embelic acid);APOPTOSIS ACTIVATOR III
- CBNumber:
- CB7365074
- Molecular Formula:
- C17H26O4
- Molecular Weight:
- 294.39
- MDL Number:
- MFCD00016369
- MOL File:
- 550-24-3.mol
- MSDS File:
- SDS
| Melting point | 142-143°C |
|---|---|
| Boiling point | 356.15°C (rough estimate) |
| Density | 1.131 |
| refractive index | 1.4230 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: >10 mg/mL |
| form | solid |
| pka | 2.84±0.50(Predicted) |
| color | Dark orange |
| Sensitive | Light Sensitive |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| LogP | 5.024 (est) |
| FDA UNII | SHC6U8F5ER |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361f |
| Precautionary statements | P201-P308+P313 |
| WGK Germany | 3 |
| RTECS | DK4230000 |
EMBELIN price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E1406 | Embelin ≥98% (HPLC), powder | 550-24-3 | 10mg | $116 | 2024-03-01 | Buy |
| Sigma-Aldrich | 178493 | Apoptosis Activator III, Embelin | 550-24-3 | 10mg | $146 | 2024-03-01 | Buy |
| Alfa Aesar | J64074 | Embelin | 550-24-3 | 10mg | $91.65 | 2024-03-01 | Buy |
| Alfa Aesar | J64074 | Embelin | 550-24-3 | 50mg | $303.65 | 2024-03-01 | Buy |
| Cayman Chemical | 11838 | Embelin ≥95% | 550-24-3 | 10mg | $68 | 2024-03-01 | Buy |
EMBELIN Chemical Properties,Uses,Production
Description
Embelin (550-24-3) inhibits?the lysine acetyl transferase PCAF?in vitro and in vivo?(in vitro?IC50=7.2 mM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged.1? Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells.3?Possesses anti-inflammatory and analgesic activity?in vivo.4?Cell-permeable.
Chemical Properties
Orange Solid
Uses
Embelin is a natural benzoquinone found in plants of the Myrsinaceae family. Embelin has a wide range of biological activity as it inhibits the growth of bacteria, fungi, protozoa and parasites. Embel in also displays contraceptive and pro-apoptotic properties.
Uses
Embelin is a natural benzoquinone found in plants of the Myrsinaceae family. Embelin has a wide range of biological activity as it inhibits the growth of bacteria, fungi, protozoa and parasites. Embelin also displays contraceptive and pro-apoptotic properties.
Definition
ChEBI: A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, an ineoplastic and inhibitory activity towards hepatitis C protease.
Biological Activity
Cell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC 50 = 4.1 μ M in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC 50 4-6 μ M), but has a weaker effect on normal prostate cells (IC 50 = 19-20 μ M). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo .
References
1) Modak?et al. (2013),?Probing p300/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor; ACS Chem. Biol.,?8?1311 2) Nikolovska-Coleska?et al. (2004),?Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database; J. Med. Chem.,?47?2430 3) Shah?et al.?(2016),?Embelin inhibits proliferation, induces apoptosis and alters gene expression profiles in breast cancer cells; Pharmacol. Rep.,?68?638 4) Chitra?et al. (1994),?Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.; Chemotherapy,?40?109
EMBELIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
View Lastest Price from EMBELIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | Pinoresinol diglucoside
550-24-3
|
US $0.00-0.00 / g | 1g | 98% | 2000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2023-02-24 | Embelin
550-24-3
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2020-01-10 | 2,5-Cyclohexadiene-1,4-dione,2,5-dihydroxy-3-undecyl-
550-24-3
|
US $9.80 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- Pinoresinol diglucoside
550-24-3
- US $0.00-0.00 / g
- 98%
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Embelin
550-24-3
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- 2,5-Cyclohexadiene-1,4-dione,2,5-dihydroxy-3-undecyl-
550-24-3
- US $9.80 / KG
- ≥98%
- Career Henan Chemical Co
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