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N,O-Bis(trimethylsilyl)acetamide

Description Uses
N,O-Bis(trimethylsilyl)acetamide
N,O-Bis(trimethylsilyl)acetamide structure
CAS No.
10416-59-8
Chemical Name:
N,O-Bis(trimethylsilyl)acetamide
Synonyms
BSA;CB2500;TMS-BA;bsa kit;tms-ba kit;TMS-BA BSA;dynasylan bsa;Co-Formula CFS-598;TMS-BA Kit BSA Kit;N,O-Bis(trimethylsil
CBNumber:
CB7366985
Molecular Formula:
C8H21NOSi2
Formula Weight:
203.43
MOL File:
10416-59-8.mol

N,O-Bis(trimethylsilyl)acetamide Properties

Melting point:
24 °C
Boiling point:
71-73 °C35 mm Hg(lit.)
Density 
0.832 g/mL at 20 °C(lit.)
vapor pressure 
10 hPa (50 °C)
refractive index 
n20/D 1.417(lit.)
Flash point:
53 °F
storage temp. 
Store below +30°C.
solubility 
Miscible with many nonpolar and polar aprotic solvents.
form 
Crystalline Powder, Crystals and/or Chunks
pka
5.82±0.50(Predicted)
color 
Light yellow or beige to brown
Specific Gravity
0.832
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
Sensitive 
Moisture Sensitive
BRN 
1306669
CAS DataBase Reference
10416-59-8(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
R14N49I64O
NIST Chemistry Reference
Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8)
EPA Substance Registry System
Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester (10416-59-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS05,GHS07,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H311-H315-H319-H341-H370-H373-H318-H226-H302-H314
Precautionary statements  P280-P305+P351+P338-P310-P201-P202-P210-P233-P240-P241+P242+P243-P260-P264-P270-P301+P312+P330-P302+P352+P312+P361+P364-P305+P351+P338+P337+P313-P307+P311-P403+P235-P405-P501-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P370+P378-P260h-P303+P361+P353-P501a
Hazard Codes  C,Xn,F
Risk Statements  10-14-22-34-40-20/21/22-11
Safety Statements  26-36/37/39-45-7/8-43A-36-30-23-16-7/9
RIDADR  UN 2920 8/PG 2
WGK Germany  3
RTECS  AK3000000
10-21
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29310095
Toxicity LD50 orally in Rabbit: 1580 mg/kg

N,O-Bis(trimethylsilyl)acetamide price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 10416-59-8 10ml $20.8 2021-03-22 Buy
Sigma-Aldrich 8.18727 N,O-Bis(trimethylsilyl)acetamide for synthesis 10416-59-8 25 mL $48.28 2021-03-22 Buy
Sigma-Aldrich 8.18727 N,O-Bis(trimethylsilyl)acetamide for synthesis 10416-59-8 100 mL $139.67 2021-03-22 Buy
Sigma-Aldrich 1.09649 N,O-Bis(trimethylsilyl)acetamide for gas chromatography 10416-59-8 25 mL $160.02 2021-03-22 Buy
Sigma-Aldrich 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 10416-59-8 1l $529 2021-03-22 Buy

N,O-Bis(trimethylsilyl)acetamide Chemical Properties,Uses,Production

Description

Clear to yellowish clear liquid liquid which is soluble in many nonpolar and polar aprotic solvents.
The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials. As it eliminated during the silylation is neutral acetamide, N,O-Bis(trimethylsilyl)acetamide can be preferably used for substrates which are acid- or base-sensitive.
N,O-bis(trimethylsilyl)-acetamide is an effective silylating agent. It is used in the pharmaceutical and in the chemical industry. Typically the silylating reaction with BSA results in neutral by-products only.

Uses

  1. Used for blocking and protection of hydroxyl groups in natural products, e.g. amino acids, carbohydrates;
  2. Used for blocking and protection of functional groups in organic intermediates;
  3. Used for formation of derivatives of H-acid compounds for analysis;
The silylated derivatives are volatile and can therefore be determined by gas chromatography. Deblocking is preferably carried out by means of hydrolysis, giving high yields. In some cases, thermal elimination of the trimethylsilyl group is possible.

Physical properties

bp 71–73°C/35 mmHg.

Uses

Powerful silylation reagent for a wide range of functional groups under mild conditions

Uses

N,O-bis(trimethylsilyl)-acetamide (BSA) is frequently used with TMCS as a catalyst to modify a variety of functional groups including carboxyl groups. In one novel application, BSA was used to measure carboxypeptidase activity by forming derivatives which could be determined by gas chromatography.BSA has been used to prepare derivatives of steroids and glucocorticoids.

Uses

N,O-Bis(trimethylsilyl)acetamide is a powerful silylating agent; reacts with a wide range of functional groups.
BSA was used to trimethylsilylate the hydroxyl group of 12 selectively to form in almost quantitative yield (eq 32).The presence of catalytic amounts (~0.02 equiv) of tetrabutylammonium fluoride (TBAF) significantly promoted the silylation of alcohols under mild conditions with high chemoselectivity, i.e., TBAF plays a role as a smooth silyl transfer catalyst from nitrogen to the hydroxyl group.

Preparation

made by the reaction of acetamide with a large excess of chlorotrimethylsilane in the presence of triethylamine.

Purification Methods

Fractionate it through a spinning band column and collect liquid b 71-73o/35mm, and not higher because the main impurity MeCONHSiMe3 distils at b 105-107o/35mm. It is used for derivatising alcohols and sugars [Klebe et al. J Am Chem Soc 88 3390 1966, see Matsuo et al. Carbohydr Res 241 209 1993, Johnson Carbohydr Res 237 313 1992]. Itis FLAMMABLE and TOXIC.

N,O-Bis(trimethylsilyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products


N,O-Bis(trimethylsilyl)acetamide Suppliers

Global( 472)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
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ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
Zjartschem
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career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
NINGBO INNO PHARMCHEM CO., LTD.
13867897135
sales@nbinno.com CHINA 925 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com CHINA 2007 58

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View Lastest Price from N,O-Bis(trimethylsilyl)acetamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-06-02 N,O-Bis(trimethylsilyl)acetamide
10416-59-8
US $6.00 / kg 1kg High quality Professional Factory Ms Ella chemwill_asia@126.com www.chemwill.com Chemwill Asia Co.,Ltd.
2019-07-06 N,O-Bis(trimethylsilyl)acetamide
10416-59-8
US $1.00 / KG 1KG 99% Customized career henan chemical co

N,O-Bis(trimethylsilyl)acetamide Spectrum


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