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Description Uses
N,O-Bis(trimethylsilyl)acetamide structure
Chemical Name:
BSA;CB2500;TMS-BA;bsa kit;tms-ba kit;TMS-BA BSA;dynasylan bsa;TMS-BA Kit BSA Kit;N,O-Bis(trimethylsil;BSA (25% in Acetonitrile)
Molecular Formula:
Formula Weight:
MOL File:

N,O-Bis(trimethylsilyl)acetamide Properties

Melting point:
24 °C
Boiling point:
71-73 °C35 mm Hg(lit.)
0.832 g/mL at 20 °C(lit.)
vapor pressure 
10 hPa (50 °C)
refractive index 
n20/D 1.417(lit.)
Flash point:
53 °F
storage temp. 
Miscible with many nonpolar and polar aprotic solvents.
Crystalline Powder, Crystals and/or Chunks
Light yellow or beige to brown
Specific Gravity
Moisture Sensitive
CAS DataBase Reference
10416-59-8(CAS DataBase Reference)
NIST Chemistry Reference
Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8)
EPA Substance Registry System
Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C,Xn,F
Risk Statements  10-14-22-34-40-20/21/22-11
Safety Statements  26-36/37/39-45-7/8-43A-36-30-23-16-7/9
RIDADR  UN 2920 8/PG 2
WGK Germany  3
RTECS  AK3000000
HazardClass  8
PackingGroup  II
HS Code  29310095
Toxicity LD50 orally in Rabbit: 1580 mg/kg
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

N,O-Bis(trimethylsilyl)acetamide price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 10416-59-8 10ml $18.7 2018-11-13 Buy
Sigma-Aldrich 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 10416-59-8 1l $493 2018-11-13 Buy
TCI Chemical A5601 BSA [=N,O-Bis(trimethylsilyl)acetamide][for Gas Chromatography] >80.0%(GC) 10416-59-8 5mL $29 2018-11-22 Buy
TCI Chemical A5602 TMS-BA [=N,O-Bis(trimethylsilyl)acetamide](25% in Acetonitrile)[for Gas Chromatography] 10416-59-8 5mL $74 2018-11-22 Buy
Alfa Aesar L00183 N,O-Bis(trimethylsilyl)acetamide, 95% 10416-59-8 25g $33.1 2018-11-13 Buy

N,O-Bis(trimethylsilyl)acetamide Chemical Properties,Uses,Production


Clear to yellowish clear liquid liquid which is soluble in many nonpolar and polar aprotic solvents.
The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials. As it eliminated during the silylation is neutral acetamide, N,O-Bis(trimethylsilyl)acetamide can be preferably used for substrates which are acid- or base-sensitive.
N,O-bis(trimethylsilyl)-acetamide is an effective silylating agent. It is used in the pharmaceutical and in the chemical industry. Typically the silylating reaction with BSA results in neutral by-products only.


  1. Used for blocking and protection of hydroxyl groups in natural products, e.g. amino acids, carbohydrates;
  2. Used for blocking and protection of functional groups in organic intermediates;
  3. Used for formation of derivatives of H-acid compounds for analysis;
The silylated derivatives are volatile and can therefore be determined by gas chromatography. Deblocking is preferably carried out by means of hydrolysis, giving high yields. In some cases, thermal elimination of the trimethylsilyl group is possible.


Powerful silylation reagent for a wide range of functional groups under mild conditions

Purification Methods

Fractionate it through a spinning band column and collect liquid b 71-73o/35mm, and not higher because the main impurity MeCONHSiMe3 distils at b 105-107o/35mm. It is used for derivatising alcohols and sugars [Klebe et al. J Am Chem Soc 88 3390 1966, see Matsuo et al. Carbohydr Res 241 209 1993, Johnson Carbohydr Res 237 313 1992]. Itis FLAMMABLE and TOXIC.

N,O-Bis(trimethylsilyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

N,O-Bis(trimethylsilyl)acetamide Suppliers

Global( 367)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 CHINA 1374 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 3015 60
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 16534 60
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880086 CHINA 559 58
Win-Win Chemical CO., Limited
0086-577-56994596 CHINA 922 58
Jinan Jianfeng Chemical Co., Ltd
15562555968 CHINA 617 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24118 58

View Lastest Price from N,O-Bis(trimethylsilyl)acetamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-04 N,O-Bis(trimethylsilyl)acetamide
US $6.00 / kg 1kg High quality Professional Factory Ms Ella Chemwill Asia Co.,Ltd.
2018-08-07 N,O-Bis(trimethylsilyl)acetamide
US $1.00 / KG 1KG 99% Customized career henan chemical co

N,O-Bis(trimethylsilyl)acetamide Spectrum

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