ChemicalBook >> CAS DataBase List >>DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE structure

CAS No.: 632-93-9

Chemical Name:: DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE

Synonyms: Dicarbethoxydihydrocollidine;1,4-Dihydro-3,5-dicarbethoxycollidine;3,5-dicarbethoxy-1,4-dihydrocollidine;3,5-diethoxycarbonyl-1,4-dihydrocollidine;3,5-dicarbethoxy-1,4-dihydrocollidine, DDC;3,5-Bis(ethoxycarbonyl)-1,4-dihydrocollidine;3,5-DIETHOXYCARBONYL-1,4-DIHYDRO-2,4,6-COLLIDINE;Diethyl 1,4-dihydro-s-collidine-3,5-dicarboxylate;3,5-DICARBETHOXY-1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE;3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >

CBNumber:: CB7373477

Molecular Formula:: C14H21NO4

Molecular Weight:: 267.32

MDL Number:: MFCD00005950

MOL File:: 632-93-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:26:16

Product description	Number	Pack Size	Price
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate 99%	137030	25g	$177
3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >98.0%(GC)	D0558	1g	$16
3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >98.0%(GC)	D0558	5g	$29
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate ≥98%	23230	10g	$37
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate ≥98%	23230	25g	$77

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DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Properties

Melting point	130-132 °C(lit.)
Boiling point	410.51°C (rough estimate)
Density	1.1116 (rough estimate)
refractive index	1.5280 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMF: 30 mg/ml; DMF:PBS (pH 7.2); (1:7): 0.125 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
form	powder to crystal
pka	3.53±0.70(Predicted)
color	White to Orange to Green
InChI	InChI=1S/C14H21NO4/c1-6-18-13(16)11-8(3)12(14(17)19-7-2)10(5)15-9(11)4/h8,15H,6-7H2,1-5H3
InChIKey	CDVAIHNNWWJFJW-UHFFFAOYSA-N
SMILES	C1(C)NC(C)=C(C(OCC)=O)C(C)C=1C(OCC)=O
CAS DataBase Reference	632-93-9(CAS DataBase Reference)
EPA Substance Registry System	3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester (632-93-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

RTECS

US7979375

TSCA

TSCA listed

HS Code

2933.39.9200

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	137030	Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate 99%	632-93-9	25g	$177	2025-07-31	Buy
TCI Chemical	D0558	3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >98.0%(GC)	632-93-9	1g	$16	2025-07-31	Buy
TCI Chemical	D0558	3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >98.0%(GC)	632-93-9	5g	$29	2025-07-31	Buy
Cayman Chemical	23230	Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate ≥98%	632-93-9	10g	$37	2024-03-01	Buy
Cayman Chemical	23230	Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate ≥98%	632-93-9	25g	$77	2024-03-01	Buy

Product number	Packaging	Price	Buy
137030	25g	$177	Buy
D0558	1g	$16	Buy
D0558	5g	$29	Buy
23230	10g	$37	Buy
23230	25g	$77	Buy

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Chemical Properties,Uses,Production

Description

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe²⁺ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.

Chemical Properties

almost white crystalline powder

Uses

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate was used to induce Mallory-Denk body formation in mice in vivo.

Definition

ChEBI: A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5.

Biochem/physiol Actions

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate blocks the heme synthesis and prevents the induction of hepatic heme oxygenase-1 in mice.

Purification Methods

Crystallise the ester from hot EtOH/water mixture. [Beilstein 22 H 147, 22 I 529, 22 II 100, 22 III/IV 1594.]

References

[1] J. ONISAWA R L. Effects of diethyl-1, 4-dihydro-2, 4,6-trimethylpyridine-3,5-dicarboxylate on the metabolism of porphyrins and iron.[J]. The Journal of Biological Chemistry, 1963, 44 1: 724-727. DOI: 10.1016/s0021-9258(18)81326-6
[2] QX YUAN. Mallory body induction in drug-primed mouse liver[J]. Hepatology, 1996, 24 3: Pages 603-612. DOI: 10.1053/jhep.1996.v24.pm0008781332
[3] J. OLIVA S. W F. Changes in IL12A methylation pattern in livers from mice fed DDC[J]. Experimental and molecular pathology, 2012, 92 2: Pages 191-193. DOI: 10.1016/j.yexmp.2012.01.001

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Suppliers

Global( 106)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7225	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24727	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53899	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39927	58
ANHUI BYERSEN BIOTECH CO. LTD	+86-15385096007 +86-17755058861	amy@byersenchemical.com	China	10000	58

Supplier	Advantage
Hubei xin bonus chemical co. LTD	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58
Chongqing Chemdad Co., Ltd	58
ANHUI BYERSEN BIOTECH CO. LTD	58

View Lastest Price from DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-06-25	DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE 632-93-9	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
	2022-02-22	3,5-Dicarbethoxy-1,4-dihydro-2,4,6-trimethylpyridine 632-93-9	US $0.00 / KG	1KG	97.8%	100 tons	Honest Joy Holdings Limited

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE
632-93-9
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

3,5-Dicarbethoxy-1,4-dihydro-2,4,6-trimethylpyridine
632-93-9
US $0.00 / KG
97.8%
Honest Joy Holdings Limited

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Spectrum

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)MS DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)¹HNMR DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)IR1 DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)IR2 DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)Raman

632-93-9(DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE)Related Search:

Diethyl pyridine-3,5-dicarboxylate DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Nimodipine 3,5-Pyridinedicarboxylic acid 2,4,6-Collidine

3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3,4,5-TRIMETHOXYPHENYL)-, DIETHYL ESTER 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(4-F& DIETHYL 4-ETHYL-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE Diethyl2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate

2,6-Dimethyl-4-(2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester AURORA 3177 LABOTEST-BB LT00261244 AURORA 3480 diethyl 2,6-dimethyl-4-thiophen-2-yl-1,4-dihydropyridine-3,5-dicarboxylate

DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-1,4-DIPHENYL-3,5-PYRIDINEDICARBOXYLATE AURORA 4028 3,5-PYRIDINEDICARBOXYLIC ACID, 4-(1,3-BENZODIOXOL-5-YL)-1,4-DIHYDRO-2,6-DIMETHYL-, DIETHYL ESTER

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DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE-3,5-DICARBOXYLATE 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 3,5-DICARBETHOXY-1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE 3,5-DIETHOXYCARBONYL-1,4-DIHYDRO-2,4,6-COLLIDINE 5-pyridinedicarboxylicacid,1,4-dihydro-2,4,6-trimethyl-diethylester Dicarbethoxydihydrocollidine diethyl dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate 3,5-dicarbethoxy-1,4-dihydrocollidine, DDC 1,4-Dihydro-2,4,6-collidine-3,5-dicarboxylic acid diethyl ester 1,4-Dihydro-2,4,6-trimethylpyridine-3,5-dicarboxylic acid diethyl ester 1,4-Dihydro-3,5-dicarbethoxycollidine 3,5-Bis(ethoxycarbonyl)-1,4-dihydrocollidine Diethyl 1,4-dihydro-s-collidine-3,5-dicarboxylate Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate,99% 3,5-dicarbethoxy-1,4-dihydrocollidine Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate,3,5-dicarbethoxy-1,4-dihydrocollidine, DDC Diethyl 1,4-dihydro-2,4,6-triMethyl-3,5-pyridinedicarboxylate, 99% 25GR 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester Diethyl 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-triMethyl-, 3,5-diethyl ester Diethyl 1,4-dihydro-2,4,6-triMethyl-3,5-pyridinedicarboxylate 99% Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate 3,5-diethoxycarbonyl-1,4-dihydrocollidine DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE (4R)-2,4,6-trimethyl-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine > DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE ISO 9001：2015 REACH 2,4,6-TRIMETHYL-1,4-DIHYDRO-PYRIDINE-3,5-DICARBOXYLIC ACID DIETHYL ESTER 632-93-9 C14H21NO4 Building Blocks C9 to C46 Heterocyclic Building Blocks Pyridines