1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
- CAS No.
- 124011-52-5
- Chemical Name:
- 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
- Synonyms
- 1,2-Distearoyl-rac-glycero-3-PG (sodium salt);1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT;sodium 2,3-bis(stearoyloxy)propyl (2,3-dihydroxypropyl) phosphate;1,2-distearoyl-sn-glycero-3-phosphatidyl-rac-glycerol sodium salt;Octadecanoic acid,1-[[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester,sodium salt
- CBNumber:
- CB7380181
- Molecular Formula:
- C42H84NaO10P
- Molecular Weight:
- 803.09
- MDL Number:
- MFCD03454063
- MOL File:
- 124011-52-5.mol
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15087 | 1,2-Distearoyl-rac-glycero-3-PG (sodium salt) ≥98% | 124011-52-5 | 100 mg | $82 | 2024-03-01 | Buy |
| Cayman Chemical | 15087 | 1,2-Distearoyl-rac-glycero-3-PG (sodium salt) ≥98% | 124011-52-5 | 250 mg | $194 | 2024-03-01 | Buy |
| Cayman Chemical | 15087 | 1,2-Distearoyl-rac-glycero-3-PG (sodium salt) ≥98% | 124011-52-5 | 500 mg | $368 | 2024-03-01 | Buy |
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Chemical Properties,Uses,Production
Description
DSPG is used in FDA approved drugs. It is an anionic phospholipid derivative. DSPG has been used to form an ionic complex with amphotericin B and encapsulate it into small unilamellar liposomes with significantly reduced toxicity (AmBisome?). DSPG-Na is a lipid reagent, which is useful in drug formulation, DNA & RNA delivery.
in vitro
Three liposome formulations were investigated: HSPC:Chol (L-EPI; 5:4 molar ratio), HSPC:Chol:DSPG (D-EPI; 5:4:1 molar ratio), and HSPC:Chol:DSPG:DSPE-mPEG(2000) (S-EPI; 5:4:1:0.3 molar ratio). Small unilamellar liposomes were prepared by the modified thin-film hydration method with extrusion through polycarbonate filters, and EPI was remote loaded into liposomes by the transmembrane ammonium sulfate gradient method._x000D_ _x000D_ Reference: J Liposome Res. 2012 Mar;22(1):80-8. https://pubmed.ncbi.nlm.nih.gov/22022836/
in vivo
Vaccination of atherosclerotic mice on a western-type diet with DSPG-liposomes encapsulating an LDL-derived peptide antigen significantly reduced plaque formation by 50% and stabilized the plaques, and reduced serum cholesterol concentrations. These results indicate that DSPG-liposomes have potential as a delivery system in vaccination against atherosclerosis._x000D_ _x000D_ Reference: J Control Release. 2018 Dec 10;291:135-146. https://pubmed.ncbi.nlm.nih.gov/30365993/
target
A phospholipid.
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Preparation Products And Raw materials
Raw materials
Preparation Products
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12431 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Suzhou Highfine Biotech Co., Ltd | 0512-68417696 13962195629 | qirl@highfine.com | China | 499 | 75 |
| Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | root@zhongyitai.com | China | 1976 | 58 |
| Wellman Pharmaceutical Group Limited | 027-027-83778875 15807197853 | 15807197853@163.com | China | 3976 | 58 |
| Suzhou C1 Technology Co.，Ltd | 18606219109 | ty.sales1@feixiangchem.com | China | 70 | 58 |
| Tianjin Kaifu Pharmaceutical Technology Co., Ltd. | 18081075745 | chemflowtech@sina.com | China | 1886 | 58 |
| Shochem(Shanghai)Co.,Ltd | +86-021-51783479 +86-13816874662 | info@shochem.com | China | 309 | 58 |
| HUNAN CHEMFISH SCIENTIFIC CO.,LTD | +86-0731-85567275 13021512891 | sales02@chemfish.com | China | 6580 | 58 |
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