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Minoxidil

an antihypertensive vasodilator medication Indications and Usage Mechanisms of Action Adverse reactions Contradictions
Minoxidil
Minoxidil
CAS No.
38304-91-5
Chemical Name:
Minoxidil
Synonyms
pdp;PPM2C;regain;LONTEN;loniten;rogaine;U-10858;alostil;lonolox;regaine
CBNumber:
CB7383531
Molecular Formula:
C9H15N5O
Formula Weight:
209.25
MOL File:
38304-91-5.mol

Minoxidil Properties

Melting point:
272-274 °C (dec.)(lit.)
Boiling point:
348.61°C (rough estimate)
Density 
1.1651 (rough estimate)
refractive index 
1.7610 (estimate)
storage temp. 
Store at RT
solubility 
Slightly soluble in water, soluble in methanol and in propylene glycol.
form 
neat
pka
4.61(at 25℃)
Water Solubility 
Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
Merck 
14,6203
CAS DataBase Reference
38304-91-5(CAS DataBase Reference)
NIST Chemistry Reference
Minoxidil(38304-91-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T+
Risk Statements  22-36/37/38-26/27/28
Safety Statements  26-36-45-36/37/39-22
WGK Germany  3
RTECS  UV8200000
Hazardous Substances Data 38304-91-5(Hazardous Substances Data)
Toxicity LD50 in rats, mice (mg/kg): 49, 51 i.v. (Carlson, Feenstra)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Minoxidil price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M4145 Minoxidil ≥99% (TLC) 38304-91-5 25mg $69 2018-11-13 Buy
Sigma-Aldrich 1444208 Minoxidil United States Pharmacopeia (USP) Reference Standard 38304-91-5 125mg $280 2018-11-13 Buy
TCI Chemical M1389 Minoxidil >98.0%(HPLC)(T) 38304-91-5 1g $23 2018-11-22 Buy
TCI Chemical M1389 Minoxidil >98.0%(HPLC)(T) 38304-91-5 5g $69 2018-11-22 Buy
Alfa Aesar J61803 Minoxidil 38304-91-5 5g $89 2018-11-13 Buy

Minoxidil Chemical Properties,Uses,Production

an antihypertensive vasodilator medication

Minoxidil is an antihypertensive vasodilator medication also claiming to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes, if experienced, disappear within months after discontinuation of treatment.
Minoxidil was first sold as a drug for high blood pressure and was noted to have the interesting side-effect of increased body hair-growth, or in some cases, significant hair loss. Treatments for baldness and hair loss usually include a 5% concentration solution that is designed for men, whereas the 2% concentration solutions are designed for women.

Indications and Usage

Minoxidil is a type of oral drug that is clinically used to lower blood pressure, and it is also called Loniten and piperidine diamine. Minoxidil is an antihypertensive drug that is clinically used to treat intractable, primary or renal hypertension. It can also be used to treat severe hypertension that does not respond well to other antihypertensive drugs, but it needs to be used in combination with diuretic drugs to prevent water and sodium retention, and combined use with beta receptor blockers may increase its curative effects and reduce adverse effects. Minoxidil is also used to prevent grease-type alopecia and on livestock.

Mechanisms of Action

Minoxidil is a type of potassium channel opener and can directly relax smooth vascular muscles and has a strong small artery dilating effect. It can reduce peripheral resistance, dilate blood vessels, and lower blood pressure while having no effect on blood volume, thus promoting venous return. In addition, due to reflective regulation and positive frequency effects, it can increase cardiac output and heart rate, but will not cause orthostatic hypotension.

Adverse reactions

Long term use of Minoxidil may have the side effect of increased body hair, such as arm hair.
Adverse reactions to oral intake mainly include: weight gain and lower body swelling due to water and sodium retention, heart palpitations and arrhythmia due to reflexive sympathetic nervous excitement, and hirsuitism.
Adverse reactions to external use mainly include: skin irritation, red spots in applied areas, itching, and other skin inflammation reactions. Although only a small amount is absorbed, but there is also a slight possibility of causing a recurrence in patients with a history or heart disease. Use with caution if suffering from cerebrovascular disease, non-hypertensive heart failure, coronary heart disease, angina pectoris, myocardial infarction, pericardial effusion, renal dysfunction and other diseases.

Contradictions

Do not use if allergic to Minoxidil or suffering from pheochromocytoma.

Chemical Properties

White Crystalline Solid

Uses

Used as an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channels

Uses

antihypertensive, antialopecia agent

Uses

A selective ATP dependent K+ (Kir6) channel activator

Definition

ChEBI: A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.

brand name

Loniten (Pharmacia & Upjohn); Rogaine (Pharmacia & Upjohn); Minodyl (Quantum Pharmics).

Biological Activity

Antihypertensive. Antialopecia agent. K + channel (K ATP ) activator.

Minoxidil Preparation Products And Raw materials

Raw materials

Preparation Products


Minoxidil Suppliers

Global( 318)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Kono Chem Co., Ltd
+86-132 8924 6953
info@konochemical.com CHINA 2164 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22060 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 893 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1582 55
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 216 58
Jinan Tenglong Chemical Co.,Ltd
Whatsapp:+8615563263311 Skype:live:smions7080
smions7080@gmail.com CHINA 778 58

View Lastest Price from Minoxidil manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-03-15 Minoxidil
38304-91-5
US $50.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.
2018-12-16 Minoxidil
38304-91-5
US $8.00 / kg 1kg 98% 10MT career henan chemical co
2018-12-15 Minoxidil
38304-91-5
US $1.00 / kg 1kg 99% Customized career henan chemical co

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