HYDROXY PENTOXIFYLLINE
- CAS No.
- 6493-06-7
- Chemical Name:
- HYDROXY PENTOXIFYLLINE
- Synonyms
- LISOFYLLINE;(+/-)-LISOFYLLINE;Penthydroxifillyne;Lisofylline (racemic);HYDROXY PENTOXIFYLLINE;5-Hydroxy pentoxifylline;pentoxyfylline metabolite 2;Hydroxy Pentoxifylline (rac-Lisofylline);3,7-Dihydro-1-(5-hydroxyhexyl)-3,7-diMethyl-;(+/-)-1-(5-HYDROXYHEXYL)-3,7-DIMETHYLXANTHINE
- CBNumber:
- CB7385818
- Molecular Formula:
- C13H20N4O3
- Molecular Weight:
- 280.32
- MDL Number:
- MFCD00871850
- MOL File:
- 6493-06-7.mol
| Melting point | 123-125°C |
|---|---|
| Boiling point | 511.2±56.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | DMSO: soluble |
| form | solid |
| pka | 15.22±0.20(Predicted) |
| color | white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| NCI Dictionary of Cancer Terms | lisofylline |
| FDA UNII | R99EE080JS |
HYDROXY PENTOXIFYLLINE price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J67181 | (±)-Lisofylline 98% | 6493-06-7 | 10mg | $123 | 2021-12-16 | Buy |
| Alfa Aesar | J67181 | (±)-Lisofylline 98% | 6493-06-7 | 25mg | $177 | 2021-12-16 | Buy |
| Cayman Chemical | 10010785 | (±)-Lisofylline ≥98% | 6493-06-7 | 10mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 10010785 | (±)-Lisofylline ≥98% | 6493-06-7 | 25mg | $117 | 2024-03-01 | Buy |
| Alfa Aesar | J67181 | (±)-Lisofylline 98% | 6493-06-7 | 50mg | $335 | 2021-12-16 | Buy |
HYDROXY PENTOXIFYLLINE Chemical Properties,Uses,Production
Description
Lisofylline (6493-06-7, racemic) displays anti-inflammatory activity. Regulates immune cell function and autoimmune response by inhibition of IL-12 signalling and cytokine production.1 Protects pancreatic beta cells and prevents type I diabetes in non-obese diabetic mice.2 Lisofylline reduces LPS-induced TNF alpha levels in CD-1 mice.3?Cell permeable.
Chemical Properties
White Solid
Uses
A major oxidative metabolite of Pentoxifylline. A potent inhibitor of phosphatidic acid generation (IC50=0.6uM). Protects mice from endotoxic shock and attenuates sepsis-induced acute lung injury in pig.
Definition
ChEBI: 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione is a dimethylxanthine that is 3,7-dihydro-1H-purine-2,6-dione which is substituted at positions 1,3 and 7 by a 5-hydroxyhexyl group, methyl group and methyl group, respectively. It is a secondary alcohol and a dimethylxanthine.
brand name
ProTec (Cell Therapeutics).
in vitro
(±)-lisofylline is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. (±)-lisofylline was found to inhibit the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase. (±)-lisofylline could also suppress the production of the proinflammatory cytokine ifn-γ, inhibit il-12-mediated stat-4 activation, as well as enhance glucose-stimulated β-cell insulin secretion [1].
in vivo
in a previous study, lisofylline was administered to female non-obese diabetic mice for 3 weeks. cytokines and blood glucose concentrations were monitored. histology and immunohistochemistry were also carried out in pancreatic sections. results showed that lisofylline was able to suppress ifn-γ production, reduce the onset of insulitis and diabetes, and inhibit diabetes [1].
References
1) Yang?et al. (2005),?Lisofylline: a potential lead for the treatment of diabetes; Biochem. Pharmacol., 69?1 2) Yang?et al. (2002),?The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice; Diabetologia,?45?1307 3) Wyska?et al. (2010),?Pharmacokinetic-pharmacodynamic modeling of methylxanthine derivatives in mice challenged with high-dose lipopolysaccharide; Pharmacology,?85?264
HYDROXY PENTOXIFYLLINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +8613627253706 | sale@hdimpurity.com | China | 1490 | 58 |
| Beijing ECom Technology Co., Ltd. | 17710328343 | 3507416996@qq.com | China | 1955 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9685 | 58 |
View Lastest Price from HYDROXY PENTOXIFYLLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-29 | Hydroxy Pentoxifylline
6493-06-7
|
US $0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD |
-
- Hydroxy Pentoxifylline
6493-06-7
- US $0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD