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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride structure
Chemical Name:
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
Molecular Formula:
Formula Weight:
MOL File:

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Properties

Melting point:
110-115 °C(lit.)
0.877 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.461
storage temp. 
H2O: soluble1 gm/10 ml, clear to very slightly hazy, colorless to very faintly yellow
Crystalline Powder
White to off-white
Water Solubility 
Stable, but sensitive to moisture. Incompatible with strong acids, strong oxidizing agents, moisture.
CAS DataBase Reference
25952-53-8(CAS DataBase Reference)
EPA Substance Registry System
1,3-Propanediamine, N'-(ethylcarbonimidoyl)- N,N-dimethyl-, monohydrochloride(25952-53-8)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C,Xi
Risk Statements  34-36/37/38-41-37/38-20/21/22
Safety Statements  26-36/37/39-45-37/39-36
RIDADR  UN 2735 8/PG 3
WGK Germany  3
RTECS  FF2200000
Hazard Note  Irritant
HS Code  29252000
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 03449 N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride ≥99.0% (AT) 25952-53-8 1g $64.4 2018-11-13 Buy
Sigma-Aldrich 03449 N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride ≥99.0% (AT) 25952-53-8 5g $180 2018-11-13 Buy
TCI Chemical D1601 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis] >98.0%(T) 25952-53-8 5g $59 2018-11-22 Buy
TCI Chemical D1601 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis] >98.0%(T) 25952-53-8 25g $160 2018-11-22 Buy
Alfa Aesar A10807 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 98+% 25952-53-8 5g $55.1 2018-11-13 Buy

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder


It is being used for the synthesis of amides. EDC.HCl is also used as a coupling agent in the preparation of esters from carboxylic acids using dimethylaminopyridine as the catalyst. It is water-soluble carbodiimide, widely used for peptide coupling.


An enzyme inhibitor

Purification Methods

It is an excellent H2O-soluble peptide coupling reagent. It is purified by dissolving (ca 1g) in CH2Cl2 (10mL) at room temperature and then add dry Et2O (~110mL) dropwise and the crystals that separate are collected, washed with dry Et2O, recrystallised from CH2Cl2/Et2O and dried in a vacuum over P2O5. It is important to work in a dry atmosphere or work rapidly and then dry the solid as soon as possible. The material is moderately hygroscopic, but once it becomes wet it reacts slowly with H2O. Store it away from moisture at -20o to slow down the hydrolysis process. The free base has b 47-48o/0.27mm, 53-54o/0.6mm, n 1.4582. The methiodide is recrystallised from CHCl3/EtOAc, the crystals are filtered off, washed with dry Et2O, recrystallised from CHCl3/Et2O, and dried in vacuo over P2O5, m 93-95o, 94-95o. [Sheehan et al. J Am Chem Soc 87 2492 1965, Sheehan & Cruickshank Org Synth Coll Vol V 555 1973.] § A polymer bound version is commercially available.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Suppliers

Global( 473)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383 CHINA 177 55
Jinan Finer Chemical Co., Ltd
+86-531-88989539 CHINA 479 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 CHINA 416 50
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19954 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 3015 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-34979012 CHINA 663 60

View Lastest Price from 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-17 EDAC hydrochloride
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2018-08-20 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
US $2.00 / KG 1KG 99% cstomise career henan chemical co
2018-08-15 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
US $1.00 / KG 1KG 99% 20kg career henan chemical co

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Spectrum

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