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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride structure
CAS No.
25952-53-8
Chemical Name:
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
Synonyms
WSC;edap;WSCD;WSCI;EDAC;EDCI;WS.HCl;Edccl;EDC.HC;EDCHC1
CBNumber:
CB7403031
Molecular Formula:
C8H18ClN3
Formula Weight:
191.7
MOL File:
25952-53-8.mol

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Properties

Melting point:
110-115 °C(lit.)
Density 
0.877 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.461
storage temp. 
-20°C
solubility 
H2O: soluble1 gm/10 ml, clear to very slightly hazy, colorless to very faintly yellow
form 
Crystalline Powder
color 
White to off-white
Water Solubility 
Soluble
Sensitive 
Hygroscopic
BRN 
5764110
Stability:
Stable, but sensitive to moisture. Incompatible with strong acids, strong oxidizing agents, moisture.
InChIKey
FPQQSJJWHUJYPU-UHFFFAOYSA-N
CAS DataBase Reference
25952-53-8(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
RJ5OZG6I4A
EPA Substance Registry System
1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride (25952-53-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H315-H318-H335-H302-H319
Precautionary statements  P280a-P304+P340-P405-P501a-P264-P270-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P261-P280-P305+P351+P338
Hazard Codes  C,Xi
Risk Statements  34-36/37/38-41-37/38-20/21/22
Safety Statements  26-36/37/39-45-37/39-36
RIDADR  UN 2735 8/PG 3
WGK Germany  3
RTECS  FF2200000
1-3-10
Hazard Note  Irritant
TSCA  Y
HS Code  29252000
Toxicity LD50 intravenous in mouse: 56mg/kg

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 03449 N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride ≥99.0% (AT) 25952-53-8 1g $21.7 2020-08-18 Buy
Sigma-Aldrich 03449 N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride ≥99.0% (AT) 25952-53-8 5g $72.3 2020-08-18 Buy
TCI Chemical D1601 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis] >98.0%(T) 25952-53-8 5g $51 2021-03-22 Buy
TCI Chemical D1601 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis] >98.0%(T) 25952-53-8 25g $163 2021-03-22 Buy
Alfa Aesar A10807 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 98+% 25952-53-8 5g $58.3 2020-06-24 Buy

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder

Uses

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is being used for the synthesis of amides. EDC.HCl is also used as a coupling agent in the preparation of esters from carboxylic acids using dimethylaminopyridine as the catalyst. It is water-soluble carbodiimide, widely used for peptide coupling.

Uses

An enzyme inhibitor

Purification Methods

It is an excellent H2O-soluble peptide coupling reagent. It is purified by dissolving (ca 1g) in CH2Cl2 (10mL) at room temperature and then add dry Et2O (~110mL) dropwise and the crystals that separate are collected, washed with dry Et2O, recrystallised from CH2Cl2/Et2O and dried in a vacuum over P2O5. It is important to work in a dry atmosphere or work rapidly and then dry the solid as soon as possible. The material is moderately hygroscopic, but once it becomes wet it reacts slowly with H2O. Store it away from moisture at -20o to slow down the hydrolysis process. The free base has b 47-48o/0.27mm, 53-54o/0.6mm, n 1.4582. The methiodide is recrystallised from CHCl3/EtOAc, the crystals are filtered off, washed with dry Et2O, recrystallised from CHCl3/Et2O, and dried in vacuo over P2O5, m 93-95o, 94-95o. [Sheehan et al. J Am Chem Soc 87 2492 1965, Sheehan & Cruickshank Org Synth Coll Vol V 555 1973.] § A polymer bound version is commercially available.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Suppliers

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Jiangsu Qingquan Chemical Co., Ltd.
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View Lastest Price from 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-26 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
25952-53-8
US $0.00 / kg 100g 99% 100mt Jinan Finer Chemical Co., Ltd
2021-10-20 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
25952-53-8
US $10.00 / KG 500g 99% 2000MT/Month Wuhan wingroup Pharmaceutical Co., Ltd
2021-10-19 EDC hydrochloride
25952-53-8
US $48.00-40.00 / KG 1KG 99% 200tons Guangzhou Sunton Biotechnology Co., Ltd.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Spectrum


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