TYRPHOSTIN B56
- CAS No.
- 133550-41-1
- Chemical Name:
- TYRPHOSTIN B56
- Synonyms
- AG 556;(E)-AG 556;TYRPHOSTIN B56;TYRPHOSTIN AG 556;AG 556 (Tyrphostin AG 556);ALPHA-CYANO-(3,4-DIHYDROXY)-N-(4-PHENYLBUTYL)CINNAMIDE;N-(4-PHENYLBUTYL)-3,4-DIHYDROXYBENZYLIDENE-CYANOACETAMIDE;2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide;(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide;(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(4-PHENYLBUTYL)-2-PROPENAMIDE
- CBNumber:
- CB7405611
- Molecular Formula:
- C20H20N2O3
- Molecular Weight:
- 336.38
- MDL Number:
- MFCD00209860
- MOL File:
- 133550-41-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H400-H410 |
| Precautionary statements | P264-P270-P273-P301+P310-P321-P330-P391-P405-P501 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
TYRPHOSTIN B56 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A427033 | AG556 | 133550-41-1 | 10mg | $165 | 2021-12-16 | Buy |
| Usbiological | 254560 | AG 556 | 133550-41-1 | 10mg | $389 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA137620 | AG556 | 133550-41-1 | 25mg | $184 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA137620 | AG556 | 133550-41-1 | 50mg | $300 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA137620 | AG556 | 133550-41-1 | 2mg | $40 | 2021-12-16 | Buy |
TYRPHOSTIN B56 Chemical Properties,Uses,Production
Uses
AG 556 is a highly selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TK inhibitor). AG 556 has been shown to decrease human atrial IKur and cloned hKv1.5 channels by inhibiting EGFR TK.
Biological Activity
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 1.1 μ M). Selective over ErbB2 (IC 50 > 500 μ M).
References
[1]. zhang dy, zhang yh, sun hy, et al. epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium k(ir)2.3 channel, stably expressed in hek 293 cells. br j pharmacol, 2011 nov, 164(5): 1469-1478
[1].
[2]. zhang dy, wu w, deng xl, et al. genistein and tyrphostin ag556 inhibit inwardly-rectifying kir2.1 channels expressed in hek 293 cells via protein tyrosine kinase inhibition. biochim biophys acta, 2011, 1808(8): 1993-1999.
[3]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[4]. sevransky je, shaked g, novogrodsky a, et al. tyrphostin ag 556 improves survival and reduces multiorgan failure in canine escherichia coli peritonitis. j clin invest, 1997, 99(8): 1966-1973.
TYRPHOSTIN B56 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN B56 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9664 | 60 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Synchem OHG | +49 5662 408730 | info@synchem.de | Germany | 4708 | 70 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |