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Naloxone hydrochloride dihydrate

CAS No.
51481-60-8
Chemical Name:
Naloxone hydrochloride dihydrate
Synonyms
NaloxonHCl-Dihydrat;Naloxone HCl dihydrate;NaloxonhydrochloridDihydrat;naloxone F&D version of N7758;loxone hydrochloride dihydrate;NALOXONE HYDROCHLORIDE, DIHYDRATE;Naloxone dihydrate hydrochloride;NALOXONEHYDROCHLORIDE,DIHYDRATE,USP;Naloxone hydrochloride dihydrate CRS;Naloxone for peak identification CRS
CBNumber:
CB7409260
Molecular Formula:
C19H26ClNO6
Molecular Weight:
399.87
MDL Number:
MFCD00150901
MOL File:
51481-60-8.mol
Last updated:2023-04-23 13:52:06

Naloxone hydrochloride dihydrate Properties

Melting point 182 °C (dec.)(lit.)
storage temp. 2-8°C
solubility ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.
form powder
color white to off-white
optical activity [α]25/D 178.6°, c = 2.5 in H2O(lit.)
Merck 13,6388
BRN 6260807
CAS DataBase Reference 51481-60-8(CAS DataBase Reference)
FDA UNII 5Q187997EE

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-26-36/37/39-36
WGK Germany  3

Naloxone hydrochloride dihydrate price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N7758 Naloxone hydrochloride dihydrate ≥98% (TLC and titration), powder 51481-60-8 1g $599 2024-03-01 Buy
Sigma-Aldrich N7758 Naloxone hydrochloride dihydrate ≥98% (TLC and titration), powder 51481-60-8 5g $760 2024-03-01 Buy
Sigma-Aldrich N7758 Naloxone hydrochloride dihydrate ≥98% (TLC and titration), powder 51481-60-8 250mg $185 2024-03-01 Buy
Sigma-Aldrich Y0000695 Naloxone for peak identification European Pharmacopoeia (EP) Reference Standard 51481-60-8 y0000695 $220 2024-03-01 Buy
Sigma-Aldrich PHR1802 Naloxone hydrochloride dihydrate Pharmaceutical Secondary Standard; Certified Reference Material 51481-60-8 300mg $267 2024-03-01 Buy
Product number Packaging Price Buy
N7758 1g $599 Buy
N7758 5g $760 Buy
N7758 250mg $185 Buy
Y0000695 y0000695 $220 Buy
PHR1802 300mg $267 Buy

Naloxone hydrochloride dihydrate Chemical Properties,Uses,Production

Chemical Properties

White or almost white, hygroscopic, crystalline powder.

Uses

Antagonist (to narcotics).

Uses

Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist.

brand name

Narcan (Bristol-Myers Squibb); Narcan (Endo).

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Purification Methods

This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.]

Naloxone hydrochloride dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 113)Suppliers
Supplier Tel Email Country ProdList Advantage
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View Lastest Price from Naloxone hydrochloride dihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Naloxone hydrochloride dihydrate pictures 2021-09-29 Naloxone hydrochloride dihydrate
51481-60-8
US $0.00-0.00 / g/Bag 1g 98%-102% 1000G WUHAN FORTUNA CHEMICAL CO., LTD
Naloxone hydrochloride dihydrate pictures 2019-07-06 Naloxone hydrochloride dihydrate
51481-60-8
US $1.00 / kg 1kg 95%-98% 100kg Career Henan Chemical Co
4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride dihydrate NALOXONE HYDROCHLORIDE, DIHYDRATE naloxone F&D version of N7758 Naloxone HCl dihydrate NALOXONE F&D VERSION OF N7758 FOR & NALOXONE F&D VERSION OF N7758 FOR HUMA& NaloxonHCl-Dihydrat NaloxonhydrochloridDihydrat Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, dihydrate, (5.alpha.)- NALOXONEHYDROCHLORIDE,DIHYDRATE,USP Naloxone dihydrate hydrochloride 17-Allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one hydrochloride dihydrate (5α)-17-allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride dihydrate Naloxone hydrochloride dihydrate 4,5alpha-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride dihydrate loxone hydrochloride dihydrate Naloxone hydrochloride dihydrate CRS Naloxone for peak identification CRS Naloxone hydrochloride dihydrate USP/EP/BP Naloxone for peak identification (Y0000695)Q: What is Naloxone for peak identification (Y0000695) Q: What is the CAS Number of Naloxone for peak identification (Y0000695) Naloxone hydrochloride dihydrateQ: What is Naloxone hydrochloride dihydrate Q: What is the CAS Number of Naloxone hydrochloride dihydrate Q: What is the storage condition of Naloxone hydrochloride dihydrate Q: What are the applications of Naloxone hydrochloride dihydrate 51481-60-8 C19H21NO4HCl2H2O C19H26ClNO6 Other Enzyme Inhibitors by Type Enzyme Inhibitors Enzymes, Inhibitors, and Substrates Biochemicals and Reagents BioChemical Opioids Antagonists Pharmacologicals Enzyme Inhibitors Enzyme Inhibitors by Type Other API