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LYSOSTAPHIN

LYSOSTAPHIN structure

CAS No.: 9011-93-2

Chemical Name:: LYSOSTAPHIN

Synonyms: Ambicin L;LYSOSTAPHIN;EC 3.4.24.75;E.C. 3.4.24.75;Lysostaphin from;LYSOSTAPHIN USP/EP/BP;Lysostaphin (600 U/mg);glycyl-glycine endopeptidase;LYSOSTAPHIN AFFINITY PURIFIED;LYSOSTAPHIN ASEPTICALLY FILLED

CBNumber:: CB7415982

Molecular Formula:

Molecular Weight:: 0

MDL Number:: MFCD00131556

MOL File:: Mol file

MSDS File:: SDS

Last updated:2026-04-21 10:31:43

Product description	Number	Pack Size	Price
Lysostaphin from Staphylococcus staphylolyticus free of DNA contaminants, suitable for Microbiome research, lyophilized powder, ≥500?units/mg protein	SAE0091	2MG	$260
Lysostaphin from Staphylococcus staphylolyticus BioUltra, ≥97% (SDS-PAGE), Protein 40-60?% by biuret, ≥2,000?units/mg protein	L4402	0.5mg	$256
Lysostaphin from Staphylococcus staphylolyticus aseptically filled	L2898	1mg	$442
Lysostaphin from Suitable for manufacturing of diagnostic kits and reagents., lyophilized powder	SRE0053	5mg	$453
Lysostaphin from Staphylococcus staphylolyticus lyophilized powder, Protein 50-70 % by biuret, ≥500 units/mg protein	L7386	1mg	$132

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LYSOSTAPHIN Properties

storage temp.	-20°C
form	powder
color	slightly brown
biological source	microbial (Staphylococcus staphylotyticus)
Water Solubility	water: 2.00-2.10mg/mL, clear to slightly hazy, colorless to light yellow
Merck	13,5659
Specific Activity	≥500units/mg protein
Major Application	diagnostic assay manufacturing
EWG's Food Scores	1
FDA UNII	63R7TZH0UA
UNSPSC Code	12352204
NACRES	NA.54

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H334
Precautionary statements	P261-P284-P501
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	3
RTECS	OL5985000
F	10-21
HS Code	3507909090
Storage Class	11 - Combustible Solids
Hazard Classifications	Resp. Sens. 1
Toxicity	LD50 (7-day) in mice, rats (mg/kg): 820, 530 i.v. (Zygmunt)

LYSOSTAPHIN price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SAE0091	Lysostaphin from Staphylococcus staphylolyticus free of DNA contaminants, suitable for Microbiome research, lyophilized powder, ≥500?units/mg protein	9011-93-2	2MG	$260	2026-03-19	Buy
Sigma-Aldrich	L4402	Lysostaphin from Staphylococcus staphylolyticus BioUltra, ≥97% (SDS-PAGE), Protein 40-60?% by biuret, ≥2,000?units/mg protein	9011-93-2	0.5mg	$256	2026-03-19	Buy
Sigma-Aldrich	L2898	Lysostaphin from Staphylococcus staphylolyticus aseptically filled	9011-93-2	1mg	$442	2026-03-19	Buy
Sigma-Aldrich	SRE0053	Lysostaphin from Suitable for manufacturing of diagnostic kits and reagents., lyophilized powder	9011-93-2	5mg	$453	2026-03-19	Buy
Sigma-Aldrich	L7386	Lysostaphin from Staphylococcus staphylolyticus lyophilized powder, Protein 50-70 % by biuret, ≥500 units/mg protein	9011-93-2	1mg	$132	2026-03-19	Buy

Product number	Packaging	Price	Buy
SAE0091	2MG	$260	Buy
L4402	0.5mg	$256	Buy
L2898	1mg	$442	Buy
SRE0053	5mg	$453	Buy
L7386	1mg	$132	Buy

LYSOSTAPHIN Chemical Properties,Uses,Production

Uses

Lysostaphin from Staphylococcus simulans has been used in a study to assess molecular cloning, sequencing, and expression of lytM, a unique autolytic gene of Staphylococcus aureus. It has also been used in a study to investigate the sequence analysis of a Staphylococcus aureus gene encoding a peptidoglycan hydrolase activity.

General Description

Chemical structure: peptide

Biochem/physiol Actions

Lysostaphin is a zinc endopeptidase with a molecular weight of approximately 25 kDa. Because lysostaphin cleaves the polyglycine cross-links in the peptidoglycan layer of the cell wall of Staphylococcus species it has been found useful for cell lysis and also as a potential anti-microbial therapeutic. pH Optimum for activity: ~7.5

in vivo

Lysostaphin (5 mg/kg, intravenous injection, once daily for 3 consecutive days) effectively clears systemic Staphylococcus aureus (MSSA) infections in CF-1 mice^[2]. Lysostaphin (50 mg/kg, intravenous injection, single dose) effectively clears Staphylococcus aureus (MSSA and MRSA) infections from the kidneys, spleen, and liver, but is not superior to repeated lower doses^[2]. Lysostaphin (1 mg/kg, intravenous injection, once daily for 3 consecutive days) combined with Oxacillin (HY-B0925A) achieves the same antibacterial effect with a lower concentration of Lysostaphin. When combined with Vancomycin, low-dose Lysostaphin (1 mg/kg) similarly shows enhanced efficacy against MRSA^[2].

Animal Model:	Systemic infection model in CF-1 mice induced by methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA)^[2]
Dosage:	1, 5, 25, 50 mg/kg
Administration:	Intravenous injection (i.v.), single high-dose administration: 25 mg/kg or 50 mg/kg intravenous injection, single dose; Once daily administration: 1 or 5 mg/kg, once daily for 3 days.
Result:	Cleared MSSA from the blood and organs of mice (5 mg/kg for 3 days). Cleared MSSA and MRSA from the kidneys, spleen, and liver (A higher single dose of 50 mg/kg). Improved effectiveness and allowed reduction of the lysostaphin dose to 1 mg/kg for MRSA infections (Combined with Oxacillin (HY-B0925A) or Vancomycin (HY-B0671)).

Description

Lysostaphin Recombinant produced in E.Coli is a non-glycosylated polypeptide chain having a molecular mass of 26.92 kDa.

Source

Escherichia Coli

Background

Lysostaphin, an endopeptidase specific for the cell wall peptidoglycan of staphylococci, is an extremely potent anti-staphylococcal agent. Lysostaphin is used as a research and diagnostic tool. Because it lyses staphylococci efficiently, it is widely used when preparing staphylococcal DNA or other cellular components for genetic and biochemical studies and for the preparation of protoplasts for transformation. Preparation and analysis of bacterial DNA has become a powerful tool used by clinical and other microbiologists in epidemiological studies aimed at tracing sources of infection or bacterial contamination.

LYSOSTAPHIN Preparation Products And Raw materials

Raw materials

Preparation Products

LYSOSTAPHIN Suppliers

Global( 158)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5975	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Creative Enzymes	1-516-855-7709	info@creative-enzymes.com	United States	8748	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	18895	58
Nanjing Duly Biotech Co.,Ltd	+undefined18013301590	doris@njduly.com	China	2448	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8614	58

Supplier	Advantage
Wuhan Fortuna Chemical Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
career henan chemical co	58
Creative Enzymes	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
Nanjing Duly Biotech Co.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58

View Lastest Price from LYSOSTAPHIN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-24	Lysostaphin 9011-93-2	US $0.00-0.00 / g	1g	98.0%	1kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-04-21	Lysostaphin 9011-93-2	US $89.00-455.00 / mg			10g	TargetMol Chemicals Inc.
2025-09-25	LYSOSTAPHIN 9011-93-2	US $6.00-0.20 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

Lysostaphin
9011-93-2
US $0.00-0.00 / g
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

Lysostaphin
9011-93-2
US $89.00-455.00 / mg
TargetMol Chemicals Inc.

LYSOSTAPHIN
9011-93-2
US $6.00-0.20 / KG
99%
Henan Fengda Chemical Co., Ltd

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lysostaphin from staphylococcus staphy-lolyticus LYSOSTAPHIN ASEPTICALLY FILLED LYSOSTAPHIN, STAPHYLOCOCCUS SIMULANS,*RE COMBINANT LYSOSTAPHIN AFFINITY PURIFIED LYSOSTAPHIN FROM STAPHYLOCOCCUS STAPHY-L OLYTICUS, ~1 U/MG glycyl-glycine endopeptidase lysostaphin from staphylococcus simulans Ambicin L E.C. 3.4.24.75 EC 3.4.24.75 Lysostaphin from LYSOSTAPHIN Lysostaphin from Staphylococcus staphylolyticus LYSOSTAPHIN ASEPTICALLY FILLED, BR，1200u/mg Native Staphylococcus staphylolyticus Lysostaphin Lysostaphin from Staphylococcus simulans, Recombinant LYSOSTAPHIN USP/EP/BP lyophilized powder, Protein 50-70 % by biuret, >=500 units/mg protein Lysostaphin from Staphylococcus staphylolyticus Lysostaphin from Staphylococcus simulans Lysostaphin (600 U/mg) Lysosomal staphylococcal enzyme 9011-93-2 Antibiotics A to Z Antibiotics G-M Antibiotics Biochemicals and Reagents BioChemical Application Index Cell Dissociation and Cell Lysis Enzymes, Inhibitors, and Substrates Lysing Enzymes and Protoplast Preparation