CORTICOSTERONE
- CAS No.
- 50-22-6
- Chemical Name:
- CORTICOSTERONE
- Synonyms
- 21-Dihydroxyprogesterone;NSC-9705;compoundb;Compound B;Azlocilline;KENDALL'S 'B';Corticosteron;CORTICOSTERONE;Reichstein's B;17-Deoxycortisol
- CBNumber:
- CB7418589
- Molecular Formula:
- C21H30O4
- Molecular Weight:
- 346.47
- MDL Number:
- MFCD00037715
- MOL File:
- 50-22-6.mol
- MSDS File:
- SDS
| Melting point | 179-183 °C(lit.) |
|---|---|
| alpha | D15 +223° (c = 1.1 in alc) |
| Boiling point | 401.19°C (rough estimate) |
| Density | 1.0413 (rough estimate) |
| refractive index | 1.4430 (estimate) |
| Flash point | 9℃ |
| storage temp. | -20°C |
| solubility | Chloroform (Sparingly, Sonicated), Ethanol (Slightly, Sonicated) |
| form | White to tan crystalline powder |
| color | White to Pale Yellow |
| optical activity | [α]20/D +223±3°, c = 1% in ethanol |
| Water Solubility | 240.5mg/L(37 ºC) |
| Merck | 2538 |
| BRN | 2339601 |
| Stability | Stable, but light sensitive. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 50-22-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | W980KJ009P |
| EPA Substance Registry System | Corticosterone (50-22-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H351 |
| Precautionary statements | P202-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313 |
| Hazard Codes | Xi,N,Xn,T,F |
| Risk Statements | 43-40-39/23/24/25-23/24/25-11 |
| Safety Statements | 36-22-45-36/37-16 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | GM7650000 |
| HS Code | 29372900 |
| Toxicity | An adrenocortical steroid with modest glucocorticoid and mineralocorticoid activity. It is the primary glucocorticoid in the rat. |
CORTICOSTERONE price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C-117 | Corticosterone solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 50-22-6 | 1mL | $99 | 2024-03-01 | Buy |
| Sigma-Aldrich | 27840 | Corticosterone ≥98.5% (HPLC) | 50-22-6 | 100mg | $33.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 235135 | Corticosterone - CAS 50-22-6 - Calbiochem Corticosteroid hormone synthesized in response to stress. | 50-22-6 | 1g | $208 | 2024-03-01 | Buy |
| Sigma-Aldrich | C174 | Corticosterone: HBC complex free flowing powder | 50-22-6 | 100MG | $182 | 2023-06-20 | Buy |
| Cayman Chemical | 16063 | Corticosterone ≥98% | 50-22-6 | 100mg | $32 | 2024-03-01 | Buy |
CORTICOSTERONE Chemical Properties,Uses,Production
Description
Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors. It is produced in response to ACTH (corticotropic hormone) and is the precursor to aldosterone synthesis. Since the production of glucocorticoids is increased by stress, it is often used as a biomarker of stress. Plasma corticosterone levels have a circadian variation and corticosterone may be important in the regulation of the sleep-
Chemical Properties
white to light yellow powder
Uses
Corticosterone: HBC complex has been used:
- in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity
- to induce acute stress in mice
- in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription
Uses
Corticosteroid is an activator of MCR.
Uses
Glucocorticoid; an intermediate in the biosynthesis of aldosterone, isolated from the adrenal cortex.
Definition
ChEBI: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glan s.
General Description
Corticosterone is a corticosteroid and aldosterone precursor produced in the adrenal glands. Serum corticosterone levels are measured by LC-MS/MS for newborn screening and diagnosis of 11-hydroxylase deficiency.
Biological Activity
Endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.
Biochem/physiol Actions
The complex of corticosterone with 2-hydroxypropyl-β-cyclodextrin (HBC) improves water solubility. HBC is a carrier molecule. Corticosterone is a rodent-specific primary adrenal corticosteroid. It displays affinity towards the glucocorticoid and mineralocorticoid receptors.
target
IL Receptor | TNF-α | AChR
storage
Room temperature
Purification Methods
Purify corticosterone by recrystallisation from Me2CO (trigonal plates), EtOH or isoPrOH. It has UV max at 240nm, and gives an orange-yellow solution with strong fluorescence on treatment with concentrated H2SO4. It is insoluble in H2O but soluble in organic solvents. [Reichstein & Euw Helv Chim Acta 2 1 1197 1938, 2 7 1287 1944; Mason et al. J Biol Chem 114 613 1936; ORD: Foltz et al. J Am Chem Soc 7 7 4359 1955; NMR: Shoolery & Rogers J Am Chem Soc 8 0 5121 1958.] The 21-O-acetyl derivative [1173-26-8] crystallises from Me2CO/Et2O with m 152.5-153o, [] D 20 +195o (c 0.6, Me2CO), and the 21-O-benzoyl derivative crystallises from AcOH/Et2O with m 201-202o [Reichstein Helv Chim Acta 2 0 953 1937]. [Beilstein 8 IV 2907.]
CORTICOSTERONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2118 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3635 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
Related articles
- Biological functions and synthesis of Corticosterone
- Corticosterone is the biological glucocorticoid in mice, rats, birds, reptiles, and amphibians, which do not have 17α-hydroxyl....
- Jun 16，2022
View Lastest Price from CORTICOSTERONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | CORTICOSTERONE
50-22-6
|
US $8.00-2.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-09-14 | CORTICOSTERONE
50-22-6
|
US $0.00-0.00 / g | 100g | 99% | 50tons | Wuhan Han Sheng New Material Technology Co.，Ltd | |
 |
2021-09-29 | Corticosterone
50-22-6
|
US $0.00 / g | 1KG | 98.0% | 20kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- CORTICOSTERONE
50-22-6
- US $8.00-2.00 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- CORTICOSTERONE
50-22-6
- US $0.00-0.00 / g
- 99%
- Wuhan Han Sheng New Material Technology Co.，Ltd
-
- Corticosterone
50-22-6
- US $0.00 / g
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
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