PICROTOXININ
- CAS No.
- 17617-45-7
- Chemical Name:
- PICROTOXININ
- Synonyms
- PICROTOXININ;Picrotoxinin CRS;PICROTOXININ USP/EP/BP;Yellowmouth Dutchmanspipe Root;6a-beta,8as*,8b-beta,9r*))-6-beta;ahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-,(1ar-(1a-alpha,2a-beta,3-bet;3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-
- CBNumber:
- CB7420980
- Molecular Formula:
- C15H16O6
- Molecular Weight:
- 292.28
- MDL Number:
- MFCD00078765
- MOL File:
- 17617-45-7.mol
- MSDS File:
- SDS
| Melting point | 203-205°C |
|---|---|
| alpha | D17 +4.4° (c = 4.28 in abs alc), +3.49° (c = 7.57 in acetone) |
| Boiling point | 354.22°C (rough estimate) |
| Density | 1.2207 (rough estimate) |
| refractive index | 1.4359 (estimate) |
| storage temp. | 2-8°C |
| pka | 13.18±0.60(Predicted) |
| LogP | -0.130 (est) |
| FDA UNII | 9K011NUF0R |
| EPA Substance Registry System | Picrotoxinin (17617-45-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P301+P310+P330 |
| Hazard Codes | T+ |
| Risk Statements | 25-28 |
| Safety Statements | 13-20-45-36/37-28 |
| RIDADR | 3172 |
| WGK Germany | 3 |
| RTECS | PC5150000 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| Toxicity | LD50 i.p. in mice: 3 mg/kg (Jarboe) |
PICROTOXININ price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001528 | Picrotoxinin European Pharmacopoeia (EP) Reference Standard | 17617-45-7 | y0001528 | $220 | 2024-03-01 | Buy |
| Sigma-Aldrich | P8390 | Picrotoxinin | 17617-45-7 | 250mg | $229 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL80339 | Picrotoxinin phyproof? Reference Substance | 17617-45-7 | 20mg | $344 | 2024-03-01 | Buy |
| TRC | P437633 | Picrotoxinin | 17617-45-7 | 500mg | $210 | 2021-12-16 | Buy |
| TRC | P437633 | Picrotoxinin | 17617-45-7 | 250mg | $130 | 2021-12-16 | Buy |
PICROTOXININ Chemical Properties,Uses,Production
Uses
Picrotoxinin is a L-glutamate and channel blockers.
Definition
ChEBI: Picrotoxinin is a picrotoxane sesquiterpenoid that is 3a,4,5,6,7,7a-hexahydro-1H-indene-3,7-dicarboxylic acid which is substituted at positions 3a, 6, and 7a by methyl, isopropenyl, and hydroxy groups, respectively; in which the double bond at position 2-3 has been epoxidised; and in which the carboxy groups at positions 3 and 7 have undergone gamma-lactone formation by O-alkylation to positions 4 and 5, respectively. A component of picrotoxin. It has a role as a plant metabolite, a GABA antagonist and a serotonergic antagonist. It is an organic heteropentacyclic compound, an epoxide, a tertiary alcohol, a gamma-lactone and a picrotoxane sesquiterpenoid.
Biochem/physiol Actions
GABAA receptor antagonist; binds to the GABA receptor-linked Cl? channel.
Enzyme inhibitor
These neurotoxic GABAA receptor antagonists, consisting of a nearly 1:1 mixture of picrotoxinin, (FW = 292.29 g/mol; CAS 17617-45-7) and picrotin (FW = 310.30 g/mol; CAS 124-87-8), is a bitter-tasting (hence the Greek prefix picros) principle, also known as cocculin, from fishberry seeds (Anamirta cocculus) and the Philippine bayating (Tinomiscium philippinense). Picrotoxin binds to the chloride channel of the receptor without displacing g-aminobutyric acid. Picrotoxin is highly toxic, exerting both stimulant and convulsant effects, and care must be exercised when handling this agent.
PICROTOXININ Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15185 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 7059 | 55 |
| Shanghai Uteam Biotechnology Co., Ltd. | 021-36031160 13311776681 | 3338195766@QQ.com | China | 5175 | 55 |
| Shanghai Biological Technology Development Co., Ltd. | 021-69955236-807 13918189704 | chinaruji@chinaruji.com | China | 5176 | 55 |
| Aikon International Limited | 025-58851090 13611564524 | lwan@aikonchem.com | China | 15952 | 58 |
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