Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Isonipecotic acid

Isonipecotic acid

Isonipecotic acid Structure
Isonipecotic acid structure
CAS No.
498-94-2
Chemical Name:
Isonipecotic acid
Synonyms
PIPERIDINE-4-CARBOXYLIC ACID;4-PIPERIDINECARBOXYLIC ACID;Inp-OH;H-INP-OH;H-PIC(4)-OH;h-dl-inp-oh;Isonipecotic aci;sonipecotic acid;ISONIPECOTIC ACID;AKOS BBS-00003783
CBNumber:
CB7426775
Molecular Formula:
C6H11NO2
Molecular Weight:
129.16
MDL Number:
MFCD00006004
MOL File:
498-94-2.mol
MSDS File:
SDS
Last updated:2023-12-06 17:20:55

Isonipecotic acid Properties

Melting point >300 °C(lit.)
Boiling point 239.22°C (rough estimate)
Density 1.1426 (rough estimate)
refractive index 1.4587 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Water
pka pK1:3.73(+1);pK2:10.72(0) (25°C)
form Powder
color White to faint pink-beige
Water Solubility soluble
Merck 14,5189
BRN 112553
CAS DataBase Reference 498-94-2(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII M5TZP1RWIE
EPA Substance Registry System 4-Piperidinecarboxylic acid (498-94-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  NS5150000
TSCA  T
HazardClass  IRRITANT
HS Code  29333999
NFPA 704
0
2 0

Isonipecotic acid Chemical Properties,Uses,Production

Chemical Properties

white to faint pink-beige powder

Uses

A GABA-A receptor partial agonist

Synthesis Reference(s)

Synthesis, p. 623, 1984
Tetrahedron Letters, 35, p. 8783, 1994 DOI: 10.1016/S0040-4039(00)78497-8

Purification Methods

It crystallises from H2O or EtOH as needles. The hydrochloride recrystallises from H2O or aqueous HCl with m 293odec (also 298odec, 300odec). [Wibaut Recl Trav Chim Pays-Bas 63 141 1944, IR: Zacharius et al. J Am Chem Soc 76 2908 1954, Beilstein 22/1 V 244.]

Isonipecotic acid synthesis

39546-32-2
498-94-2
Synthesis of Isonipecotic acid from Isonipecotamide

Isonipecotic acid Preparation Products And Raw materials

Raw materials

Preparation Products

BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE N-BOC-ISONIPECOTIC ACID 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID 1-ACETYLISONIPECOTOYL CHLORIDE
PHENYL(PIPERIDIN-4-YL)METHANONE 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde 1-ACETYL-4-BENZOYLPIPERIDINE N-BOC-piperidine-4-carboxylic acid 4-(Boc-Aminomethyl)piperidine
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole 1-Methylpiperidin-4-amine 1-(4-ACETYLPIPERIDINO)ETHAN-1-ONE 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE 1-Boc-4-(aminomethyl)piperidine
1-Acetyl-4-piperidinecarboxylic acid 4-Benzylpiperidine 4-N-BOC-Aminopiperidine 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 4-Cyanopiperidine
1-Boc-4-cyanopiperidine 1-(PIPERIDIN-4-YLCARBONYL)PIPERIDINE

1of5

Isonipecotic acid Spectrum

Isonipecotic acid(498-94-2)MSIsonipecotic acid(498-94-2)1HNMRIsonipecotic acid(498-94-2)IR1Isonipecotic acid(498-94-2)IR2Isonipecotic acid(498-94-2)Raman

498-94-2(Isonipecotic acid)Related Search:

2,2,6,6-Tetramethyl-4-piperidinol Citric acid Isonipecotic acid ethyl,ISONIPECOTIC ACID ETHYL ESTER Folic acid DROPERIDOL
ISONIPECOTIC ACID, METHYL AND ETHYL ESTERS,Isonipecotic acid methyl Hyaluronic acid Triacetonediamine Haloperidol Ethyl 2-(Chlorosulfonyl)acetate
Benzyl 4-hydroxy-1-piperidinecarboxylate Ascoric Acid Azido-PEG1-CH2CO2H 4-HYDROXY-3-METHYLBENZOIC ACID Hexahydroisonicotinamide
4-Pyrimidinecarboxylic acid 4,4-Piperidinediol hydrochloride PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE

1of4

4 - piperidine forMic acid Isonipecotic aci Isonipecotic acid, 99% 25GR Piperidin-4-carboxylic acid 4-PIPERIDINECARBOXYLIC ACID FOR SYNTHESI Piperidine-4-carboxylic acid or isonipecotic acid AKOS BBS-00003783 DL-ISOPIPECOLINIC ACID H-PIC(4)-OH ISONIPECOTIC ACID HEXAHYDROISONICOTINIC ACID H-INP-OH H-ISONICOT(H6)-OH L-ISONIPECOTIC ACID LABOTEST-BB LT00847733 4-hexahydroisonicotinicacid acideisonipecotique acidepiperidine-carboxylique-4 TIMTEC-BB SBB004231 4-CARBOXYPIPERIDINE DL-ISOPIPECOLINIC ACID / 4-PIPERIDINECARBOXYLIC ACID Isonipecotic acid≥ 99% (Titration) 4-Piperidinecarboxylic acid for synthesis IsonipecoticAcid98% 4-PiperidinecarboxylicAcid/IsonipecoticAcid (n)-piperidine-4-carboxylic acid h-dl-inp-oh Piperidine-4-carboxylic acid 98% 4-PIPERIDINECARBOXLIC ACID PIPERIDINE-4-CARBOXYLIC ACID , ISONIPECOTIC ACID PIPERIDIN-4-YLCARBOXYLIC ACID ISONIPECOTIC ACID PIPERIDINE-4-CARBOXYLIC ACID 4-[(1-oxopropyl)phenylamino]-1-(phenylmethyl)- 4-Piperidinecarboxylic acid, Hexahydroisonicotinic acid 4-Piperidinecarboxylic acid ,98% Piperidine-4-carbonic acid Isonipecotic acid,99% Isonipecotic acid , 97+% 4-acid piperidine Isonipecotic acid, 99% 100GR RARECHEM AH CK 0178 4-Piperidinecaboxylic Acid DL-Isonipecotic acid H-DL-Inp-OH~(+/-)-Piperidine-4-carboxylic acid Hexahydroisonicotine acid Isonipecotic acid, 4-Carboxypiperidine sonipecotic acid 4-PiperidinecarboxylicAcid> Isonipecotic acid ISO 9001：2015 REACH 4-PIPERIDINECARBOXYLIC ACID Inp-OH PIPERIDINE-4-CARBOXYLIC ACID 4-Piperidinecarboxylic acid (9CI, ACI) Avatrombopag Impurity 67 4-piperidinic acid 498-94-2 198-94-2 C23H28N2O3C2H2O4