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Triacetin

Chemical properties Uses Production Content analysis Toxicity
Triacetin
Triacetin structure
CAS No.
102-76-1
Chemical Name:
Triacetin
Synonyms
Vanay;Glyped;Enzactin;tri-aceti;TRIACETIN;FEMA 2007;Triaeetin;Fungacetin;triacetate;Triacetine
CBNumber:
CB7441695
Molecular Formula:
C9H14O6
Formula Weight:
218.2
MOL File:
102-76-1.mol

Triacetin Properties

Melting point:
3 °C(lit.)
Boiling point:
258-260 °C(lit.)
Density 
1.16 g/mL at 25 °C(lit.)
vapor density 
7.52 (vs air)
refractive index 
n25/D 1.429-1.431(lit.)
FEMA 
2007 | (TRI-)ACETIN
Flash point:
300 °F
solubility 
Soluble in water, miscible with ethanol (96 per cent) and toluene.
form 
Liquid
color 
Clear colorless
explosive limit
1.05%, 189°F
Water Solubility 
64.0 g/L (20 ºC)
Merck 
14,9589
JECFA Number
920
BRN 
1792353
Stability:
Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey
URAYPUMNDPQOKB-UHFFFAOYSA-N
CAS DataBase Reference
102-76-1(CAS DataBase Reference)
NIST Chemistry Reference
1,2,3-Propanetriol, triacetate(102-76-1)
EPA Substance Registry System
1,2,3-Propanetriol, triacetate(102-76-1)
SAFETY
  • Risk and Safety Statements
Safety Statements  23-24/25
WGK Germany  1
RTECS  AK3675000
Autoignition Temperature 809 °F
TSCA  Yes
HS Code  29153930
Toxicity LD50 i.v. in mice: 1600 ±81 mg/kg (Wretlind)

NFPA 704

Diamond Hazard Value Description
1
0
Health  
Flammability   1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
Special  

(NFPA, 2010)

Triacetin price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 525073 Triacetin 99% 102-76-1 1l $74.5 2018-11-13 Buy
Sigma-Aldrich 1675007 Triacetin United States Pharmacopeia (USP) Reference Standard 102-76-1 1g $352.8 2018-11-13 Buy
TCI Chemical G0086 Triacetin >99.0%(GC) 102-76-1 25g $16 2018-11-22 Buy
TCI Chemical G0086 Triacetin >99.0%(GC) 102-76-1 500g $27 2018-11-22 Buy
Alfa Aesar A17132 Glycerol triacetate, 99% 102-76-1 500g $28 2018-11-13 Buy

Triacetin Chemical Properties,Uses,Production

Chemical properties

Colorless, odorless oily liquid. It is miscible with ethanol, ether, benzene, chloroform and other organic solvents, soluble in acetone, insoluble in mineral oil. Slightly soluble in water. 25 ° C in water solubility of 5.9g / 100ml.

Uses

Production

It can be derived from the esterification of glycerol and acetic acid. After preheating glycerol to 50-60 ° C, add acetic acid, benzene and sulfuric acid. Heat and stir for refluxing dehydration, and recycle the benzene. Then add acetic anhydride for heating of 4h. After cooling, the mixture was neutralized with 5% sodium carbonate to pH 7, and the crude layer was dried and the crude oil was dried with calcium chloride. Distill under reduced pressure, collect the 128-131 ° C (0.93 kPa) fraction, namely glycerol triacetate.

Content analysis

Accurately weigh about 1g of the sample, put it into a suitable pressure bottle, add 25 mL of 1mol / L. potassium hydroxide solution and 15 mL of isopropyl alcohol, add stopper, wrap with cloth and put it in a canvas bag. Put it into the water bath of 98 ℃ ± 2 ℃ for 1h, and the water level in the water bath should be slightly higher than the bottle level. Take the bottle out from the bag, cool it to room temperature in the air, unfold the cloth and stopper to release the residual pressure in the bottle, and then remove the cloth. Add 6 to 8 drops of phenolphthalein test solution (TS-167), apply 0.5mol / L sulfuric acid for titration of excess alkali until the pink could just disappeared. At the same time, perform a blank test. Each mL of 0.5mol / L sulfuric acid is equivalent to 36.37 mg of glyceryl triacetate (C9H14O6).

Toxicity

ADI is not subject to special provisions (FAO / WHO, 2001).
GR.AS (FDA, § 182.1901, 2000).
LD50 3000mg / kg (rat, oral).

Description

§ 184.1901(a) Triacetin (C8H14O6), also known as 1,2,3-propanetriol triacetate or glyceryl triacetate, is the triester of glycerin and acetic acid. Triacetin can be prepared by heating glycerin with acetic anhydride alone or in the presence of finely divided potassium hydrogen sulfate. It can also be prepared by the reaction of oxygen with a liquid-phase mixture of allyl acetate and acetic acid using a bromide salt as a catalyst.

Chemical Properties

Triacetin has a very faint, fruity odor. It has a mild, sweet taste that is bitter above 0.05%.

Chemical Properties

Colorless liquid; slight fatty odor; bitter taste. Slightly soluble in water; very soluble in alcohol, ether, and other organic solvents. Combustible.

Chemical Properties

Triacetin is a colorless, viscous liquid with a slightly fatty odor.

Occurrence

Reported found in papaya.

Uses

Triacetin is a colorless, oily liquid of slight fatty odor and bitter taste. It is soluble with water and is miscible with alcohol and ether. It functions in foods as a humectant and solvent.

Uses

As fixative in perfumery; solvent in manufacture of celluloid, photographic films. Technical triacetin (a mixture of mono-, di-, and small quantities of triacetin) as a solvent for basic dyes, particularly indulines, and tannin in dyeing.

Definition

ChEBI: A triglyceride obtained by acetylation of the three hydroxy groups of glycerol. It has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.

Preparation

By direct reaction of glycerol with acetic acid in the presence of Twitchell’s reagent, or in benzene solution of glycerol and boiling acetic acid in the presence of a cationic resin (Zeo-Karb H) pretreated with dilute H2SO4.

Production Methods

Triacetin is prepared by the esterification of glycerin with acetic anhydride.

Taste threshold values

Sweet and creamy with an oily mouthfeel.

Pharmaceutical Applications

Triacetin is mainly used as a hydrophilic plasticizer in both aqueous and solvent-based polymeric coating of capsules, tablets, beads, and granules; typical concentrations used are 10–35% w/w.
Triacetin is used in cosmetics, perfumery, and foods as a solvent and as a fixative in the formulation of perfumes and flavors.

Contact allergens

Triacetin is a component of cigarette filters, which induced a contact dermatitis in a worker at a cigarette manufactory.

Clinical Use

Glyceryl triacetate (Enzactin, Fungacetin) is a colorless, oilyliquid with a slight odor and a bitter taste. The compound issoluble in water and miscible with alcohol and most organicsolvents.
The activity of triacetin is a result of the acetic acid releasedby hydrolysis of the compound by esterases presentin the skin. Acid release is a self-limiting process becausethe esterases are inhibited below pH 4.

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. An eye irritant. Combustible when exposed to heat, flame, or powerful oxidizers. To fight fire, use alcohol foam, water, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Triacetin is used in oral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels employed as an excipient.
LD50 (dog, IV): 1.5 g/kg
LD50 (mouse, IP): 1.4 g/kg
LD50 (mouse, IV): 1.6 g/kg
LD50 (mouse, oral): 1.1 g/kg
LD50 (mouse, SC): 2.3 g/kg
LD50 (rabbit, IV): 0.75 g/kg
LD50 (rat, IP): 2.1 g/kg
LD50 (rat, oral): 3 g/kg
LD50 (rat, SC): 2.8 g/kg

storage

Triacetin is stable and should be stored in a well-closed, nonmetallic container, in a cool, dry place.

Incompatibilities

Triacetin is incompatible with metals and may react with oxidizing agents. Triacetin may destroy rayon fabric.

Regulatory Status

GRAS listed. Accepted in Europe as a food additive in certain applications. Included in the FDA Inactive Ingredients Database (oral capsules and tablets and gels). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Triacetin Preparation Products And Raw materials

Raw materials

Preparation Products


Triacetin Suppliers

Global( 292)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 207 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21668 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58

View Lastest Price from Triacetin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-14 Triacetin
102-76-1
US $1.00 / kg 1kg As customer's need CARA26 career henan chemical co

Triacetin Spectrum


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